INT125960

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.87
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptprs) cell adhesion (Ptprs)
Anatomy Link Frequency
retinas 1
Tufts 1
optic nerves 1
Ptprs (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 5 99.62 Very High Very High Very High
imagery 134 96.04 Very High Very High Very High
Central nervous system 9 83.76 Quite High
Peripheral nervous system 2 77.72 Quite High
Neuronal excitability 17 75.60 Quite High
depression 8 64.88 Quite High
anesthesia 31 63.28 Quite High
Traumatic nerve injury 2 49.92 Quite Low
nMDA receptor 1 36.32 Quite Low
Inflammation 5 31.48 Quite Low
Disease Link Frequency Relevance Heat
Anaerobic Bacterial Infections 8 99.98 Very High Very High Very High
Targeted Disruption 82 99.56 Very High Very High Very High
Adenocarcinoma 198 96.68 Very High Very High Very High
Cicatrix 2 94.76 High High
Pancreatic Cancer 42 89.68 High High
Ganglion Cysts 2 88.20 High High
Death 8 87.12 High High
Cancer 102 85.48 High High
Disease 24 81.80 Quite High
Injury 3 81.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although we found that RPTPsigma is expressed by adult RGCs in wild-type mice, the retinas and optic nerves of adult RPTPsigma (-/-) mice showed no histological defects.
Gene_expression (expressed) of RPTPsigma in retinas
1) Confidence 0.78 Published 2005 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 15797710 Disease Relevance 0.52 Pain Relevance 0.16
In this equation, PTP = V × RL+ VT/Cdyn, PTP is transpulmonary pressure (or in the mouse ?
Gene_expression (pressure) of PTP
2) Confidence 0.43 Published 2007 Journal Respir Res Section Body Doc Link PMC2039738 Disease Relevance 0 Pain Relevance 0.12
In this equation, PTP = V × RL+ VT/Cdyn, PTP is transpulmonary pressure (or in the mouse ?
Gene_expression (/) of PTP
3) Confidence 0.43 Published 2007 Journal Respir Res Section Body Doc Link PMC2039738 Disease Relevance 0 Pain Relevance 0.12
In this equation, PTP = V × RL+ VT/Cdyn, PTP is transpulmonary pressure (or in the mouse ?
Gene_expression (/) of PTP
4) Confidence 0.43 Published 2007 Journal Respir Res Section Body Doc Link PMC2039738 Disease Relevance 0 Pain Relevance 0.12
Plectin-1 targeted peptide (PTP) (amino acid sequence: KTLLPTP) or control peptide were synthesized by Tufts Peptide Core Facility with a GGSK(FITC)C linker for conjugation of the peptide to a model fluorescent nanoparticle (crosslinked iron oxides [CLIO]-Cy5.5).
Gene_expression (synthesized) of PTP in Tufts
5) Confidence 0.33 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2292750 Disease Relevance 0.09 Pain Relevance 0
Finally, the researchers attached this plectin-1–targeted peptide (PTP) to a nanoparticles that was both magnetic and fluorescent (PTP-NP) and used special microscopy (which detects the fluorescent part of this very small particle) and MRI (which detects its magnetic portion) to show that this potential imaging probe was found in areas of PDAC (but not in normal pancreatic tissue) in the mouse model of human PDAC.


Gene_expression (attached) of PTP-NP associated with adenocarcinoma and imagery
6) Confidence 0.33 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2292750 Disease Relevance 1.05 Pain Relevance 0.16
Although we found that RPTPsigma is expressed by adult RGCs in wild-type mice, the retinas and optic nerves of adult RPTPsigma (-/-) mice showed no histological defects.
Gene_expression (expressed) of RPTPsigma in optic nerves
7) Confidence 0.26 Published 2005 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 15797710 Disease Relevance 0.52 Pain Relevance 0.16
In the presence of a NMDAR antagonist, a 100 Hz tetanus produced 120.7±4.3% and 142.4±9.7% PTP in WT and KO slices, respectively.
Gene_expression (produced) of PTP associated with targeted disruption, antagonist and anaerobic bacterial infections
8) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.70 Pain Relevance 0.15

General Comments

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