INT125974

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.27
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) transport (Slc6a4)
plasma membrane (Slc6a4)
Anatomy Link Frequency
midline 1
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 69 99.76 Very High Very High Very High
Nucleus accumbens 64 98.72 Very High Very High Very High
Dopamine 98 98.32 Very High Very High Very High
Inflammation 1 97.12 Very High Very High Very High
Ventral tegmentum 8 96.56 Very High Very High Very High
Central nervous system 2 96.56 Very High Very High Very High
sSRI 10 91.60 High High
antagonist 22 91.24 High High
antidepressant 4 90.44 High High
agonist 4 84.84 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 1 98.64 Very High Very High Very High
Diarrhoea 2 98.48 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

6 98.00 Very High Very High Very High
INFLAMMATION 1 97.12 Very High Very High Very High
Constipation 3 96.08 Very High Very High Very High
Sprains And Strains 104 94.80 High High
Stress 13 77.40 Quite High
Handedness 12 76.32 Quite High
Functional Bowel Disorder 2 75.00 Quite High
Dyspepsia 1 72.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To address this possibility, we looked for an association between SNP variants and TST immobility for known coding SNPs in Tph2, Slc6a4, all serotonin receptors, and the genes for corticotrophin releasing hormone (Crh) and the Crh receptors.
Localization (immobility) of Slc6a4 associated with serotonin
1) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012073 Disease Relevance 0.60 Pain Relevance 0.37
In contrast to ectopic expression of Zic2 or EphB1, we found that electroporation of Sert (pCAG-Sert) in central RGCs did not affect guidance at the midline (Figure 8D).
Localization (electroporation) of Sert in midline
2) Confidence 0.63 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.18 Pain Relevance 0
Potentiation of 5-HT due to the SERT decrease could account for the discomfort and diarrhea of IBS-D, while receptor desensitization may cause constipation.
Localization (decrease) of SERT associated with constipation and diarrhoea
3) Confidence 0.62 Published 2005 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 15798484 Disease Relevance 0.99 Pain Relevance 0.40
In other words, MDMA-induced DA release in the NAcc is only partially carrier (DAT) - mediated but also involves a SERT-dependent 5-HT release.
Localization (release) of SERT associated with nucleus accumbens and dopamine
4) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775951 Disease Relevance 0.05 Pain Relevance 0.75
Indeed, functional pre-synaptic 5-HT2B receptors are required for MDMA-induced SERT dependent 5-HT release in vivo and in vitro [19].
Localization (release) of SERT
5) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775951 Disease Relevance 0 Pain Relevance 0.45

General Comments

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