INT125980

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 14
Disease Relevance 10.96
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CFD) extracellular space (CFD) extracellular region (CFD)
Anatomy Link Frequency
plasma 2
neck 1
brain 1
lung 1
CFD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 224 98.92 Very High Very High Very High
Pain 9 98.48 Very High Very High Very High
fibrosis 385 97.48 Very High Very High Very High
Angina 1 96.52 Very High Very High Very High
Spinal cord 1 79.32 Quite High
cytokine 49 78.56 Quite High
Inflammatory mediators 7 74.56 Quite High
alcohol 19 73.64 Quite High
cannabis 104 65.28 Quite High
imagery 4 59.20 Quite High
Disease Link Frequency Relevance Heat
Polyostotic Fibrous Dysplasia 19 100.00 Very High Very High Very High
Thrombosis 1 100.00 Very High Very High Very High
Hypersensitivity 28 99.96 Very High Very High Very High
Sunburn 7 99.32 Very High Very High Very High
Fibrosis 350 99.28 Very High Very High Very High
INFLAMMATION 210 98.92 Very High Very High Very High
Disease 120 98.92 Very High Very High Very High
Neck Pain 2 98.68 Very High Very High Very High
Vomiting 7 98.60 Very High Very High Very High
Pulmonary Fibrosis 84 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This report is also noteworthy for its dramatic depiction of leontiasis ossea, a peculiar facial deformity sometimes associated with PFD.


PFD Binding (associated) of associated with polyostotic fibrous dysplasia
1) Confidence 0.42 Published 2006 Journal Head Face Med Section Body Doc Link PMC1562402 Disease Relevance 1.87 Pain Relevance 0.09
BACKGROUND: The procoagulant factor D-dimer has been shown to be associated with thrombus formation and degradation as seen with conditions such as myocardial infarction and unstable angina.
procoagulant factor D-dimer Binding (associated) of associated with angina, myocardial infarction and thrombosis
2) Confidence 0.33 Published 2006 Journal Am J Geriatr Psychiatry Section Abstract Doc Link 16861374 Disease Relevance 0.37 Pain Relevance 0.10
Pharmacokinetic parameters after multiple doses were similar to those after single doses, and concomitant intake of food reduced by 20% the rate and extent of absorption, which are associated with better tolerability of PFD.
PFD Binding (tolerability) of
3) Confidence 0.17 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.23 Pain Relevance 0.03
PFD has been evaluated for its tolerability and usefulness in patients with advanced idiopathic pulmonary fibrosis and other lung diseases.
PFD Binding (tolerability) of in lung associated with fibrosis, pulmonary disease and pulmonary fibrosis
4) Confidence 0.17 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.32 Pain Relevance 0.32
By the end of the 5 min infusion, PFD and its two main metabolites, hydroxypirfenidone and carboxypirfenidone, were detected, and mean peak plasma concentration of PFD was 182.5 ?
PFD Binding (concentration) of in plasma
5) Confidence 0.17 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.26 Pain Relevance 0
Thus, these pharmacokinetic results support a tied regimen of PFD in patients with fibrotic disease.
PFD Binding (regimen) of associated with fibrosis and disease
6) Confidence 0.17 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.09 Pain Relevance 0.30
By the end of the 5 min infusion, PFD and its two main metabolites, hydroxypirfenidone and carboxypirfenidone, were detected, and mean peak plasma concentration of PFD was 182.5 ?
PFD Binding (metabolites) of in plasma
7) Confidence 0.17 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.28 Pain Relevance 0
Pharmacokinetics of PFD in human and animal models
PFD Binding (Pharmacokinetics) of
8) Confidence 0.17 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.42 Pain Relevance 0.04
Thus, PFD can inhibit allergic and non-allergic inflammatory cell recruitment, and its pulmonary anti-inflammatory activity is independent of TNF-?
PFD Neg (inhibit) Binding (inhibit) of associated with inflammation and hypersensitivity
9) Confidence 0.17 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.55 Pain Relevance 0.34
2.0, df?
df Binding (2.0) of
10) Confidence 0.15 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 1.10 Pain Relevance 0.03
2.2, df?
df Binding (2.2) of
11) Confidence 0.15 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 1.08 Pain Relevance 0.03
Unlike cases associated with PFD, all cases presented with acute neck pain without significant neurological impairment after minor trauma.
PFD Binding (associated) of in neck associated with pain, neck pain and injury
12) Confidence 0.06 Published 2004 Journal Br J Neurosurg Section Abstract Doc Link 15799160 Disease Relevance 1.04 Pain Relevance 0.13
The marked influence of sleep deprivation on performance (see Figures 4 and 5) was paralleled by significant alterations in CMRglc in DPFC, DStr, precuneate cortex, and MTL (Figure 8), demonstrating the contribution of a sleep-related factor to brain regions engaged by the DMS task (DF3 in Figure 9).
DF3 Binding (engaged) of in brain associated with sleep disorders
13) Confidence 0.03 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1188239 Disease Relevance 0.30 Pain Relevance 0
For EVR DF and duration, we first removed the effect of individual by performing a univariate ANOVA (independent variable?
EVR DF Binding (duration) of
14) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671607 Disease Relevance 0 Pain Relevance 0

General Comments

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