INT125993

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Context Info
Confidence 0.08
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a) kinase activity (Camk2a)
Camk2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 2 98.04 Very High Very High Very High
gABA 3 96.32 Very High Very High Very High
Glutamate 6 95.80 Very High Very High Very High
Hippocampus 3 91.28 High High
Desipramine 1 82.04 Quite High
fluoxetine 1 80.88 Quite High
antidepressant 4 79.04 Quite High
Disease Link Frequency Relevance Heat
Stress 1 74.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In synaptic membranes of chronically treated rats we found a marked reduction in the protein-protein interaction between syntaxin 1 and Thr286-phosphorylated alphaCaM kinase II (alpha-calcium/calmodulin-dependent protein kinase II) (an interaction previously proposed to promote neurotransmitter release) and a marked increase in the interaction between syntaxin 1 and Munc-18 (an interaction proposed to reduce neurotransmitter release).
Negative_regulation (reduction) of kinase II Binding (interaction) of associated with neurotransmitter
1) Confidence 0.08 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15800181 Disease Relevance 0.07 Pain Relevance 0.85

General Comments

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