INT125996

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.73
Pain Relevance 5.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

vesicle-mediated transport (Nsf) ATPase activity (Nsf) plasma membrane (Nsf)
cytoplasm (Nsf)
Anatomy Link Frequency
brain 2
cortex 1
hippocampus 1
Nsf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 30 99.60 Very High Very High Very High
Central grey 10 99.40 Very High Very High Very High
Neurotransmitter 7 98.80 Very High Very High Very High
fluoxetine 16 98.48 Very High Very High Very High
Hippocampus 14 98.44 Very High Very High Very High
antidepressant 24 94.64 High High
Serotonin 1 92.64 High High
Glutamate 6 91.76 High High
gABA 3 79.44 Quite High
cerebral cortex 5 74.64 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 10 99.40 Very High Very High Very High
Anxiety Disorder 36 99.20 Very High Very High Very High
Targeted Disruption 2 93.76 High High
Depression 29 91.48 High High
Stress 18 88.16 High High
Cognitive Disorder 30 66.72 Quite High
Disease 2 5.00 Very Low Very Low Very Low
Schizophrenia 1 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 1 5.00 Very Low Very Low Very Low
Affective Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, N-ethylmaleimide-sensitive factor gene expression was not changed after repeated morphine exposures in these brain regions.
Gene_expression (expression) of N-ethylmaleimide-sensitive factor in brain associated with morphine
1) Confidence 0.75 Published 2006 Journal Neuroreport Section Abstract Doc Link 16361953 Disease Relevance 0.18 Pain Relevance 0.85
Furthermore, we found a selective reduction in the expression level of the three proteins forming the core SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex.
Gene_expression (expression) of N-ethylmaleimide-sensitive factor
2) Confidence 0.65 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15800181 Disease Relevance 0.06 Pain Relevance 0.79
In the present study, we found that both fluoxetine and imipramine displayed anxiolytic properties when uCMS-exposed rats were tested in the NSF, but not in the EPM.
Neg (not) Gene_expression (tested) of NSF associated with anxiety disorder and fluoxetine
3) Confidence 0.57 Published 2008 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2634526 Disease Relevance 0.89 Pain Relevance 0.63
Single and repeated morphine administrations differently regulate expression of N-ethylmaleimide-sensitive factor gene in the rat brain.
Gene_expression (expression) of N-ethylmaleimide-sensitive factor in brain associated with morphine
4) Confidence 0.51 Published 2006 Journal Neuroreport Section Title Doc Link 16361953 Disease Relevance 0.15 Pain Relevance 0.80
After a single morphine injection (10 mg/kg), N-ethylmaleimide-sensitive factor gene expression increased significantly in the cortex, hippocampus and periaqueductal gray.
Gene_expression (expression) of N-ethylmaleimide-sensitive factor in hippocampus associated with hippocampus, central grey and morphine
5) Confidence 0.51 Published 2006 Journal Neuroreport Section Abstract Doc Link 16361953 Disease Relevance 0.16 Pain Relevance 0.80
The present study investigated the potential effects of single and repeated morphine treatments on gene expression of N-ethylmaleimide-sensitive protein, a key regulatory protein of neurotransmitter release and synaptic plasticity.
Gene_expression (expression) of N-ethylmaleimide-sensitive protein associated with neurotransmitter and morphine
6) Confidence 0.51 Published 2006 Journal Neuroreport Section Abstract Doc Link 16361953 Disease Relevance 0.13 Pain Relevance 0.64
After a single morphine injection (10 mg/kg), N-ethylmaleimide-sensitive factor gene expression increased significantly in the cortex, hippocampus and periaqueductal gray.
Gene_expression (expression) of N-ethylmaleimide-sensitive factor in cortex associated with hippocampus, central grey and morphine
7) Confidence 0.17 Published 2006 Journal Neuroreport Section Abstract Doc Link 16361953 Disease Relevance 0.16 Pain Relevance 0.80

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