INT12603

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Context Info
Confidence 0.63
First Reported 1980
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.66
Pain Relevance 5.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
hypothalamus 2
spinal cord 2
cerebral cortex 2
brain 2
uterine 2
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 232 100.00 Very High Very High Very High
GABA receptor 13 100.00 Very High Very High Very High
Clonidine 7 99.98 Very High Very High Very High
cerebral cortex 8 99.68 Very High Very High Very High
Glutamate 45 99.44 Very High Very High Very High
agonist 69 98.88 Very High Very High Very High
Spinal cord 4 97.08 Very High Very High Very High
electroacupuncture 2 95.48 Very High Very High Very High
ketamine 3 94.72 High High
Hippocampus 4 94.48 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 11 93.84 High High
Hypothermia 2 93.68 High High
Nociception 2 90.60 High High
Radiation Sickness 1 88.00 High High
Hypertension 1 75.00 Quite High
Dysmenorrhea 1 29.96 Quite Low
Toxicity 1 29.36 Quite Low
Schizophrenia 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both compounds increased the specific GABA receptor binding.
Positive_regulation (increased) of GABA Binding (binding) of associated with gaba receptor
1) Confidence 0.63 Published 1980 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 6258330 Disease Relevance 0.09 Pain Relevance 0.42
These results are discussed in terms of gamma-aminobutyric acid (GABA) since it is known that diazepam enhances binding of GABA to its receptor and hence potentiates inhibitory effects of GABA in the spinal cord.
Positive_regulation (enhances) of GABA Binding (binding) of in spinal cord associated with gaba and spinal cord
2) Confidence 0.41 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3614765 Disease Relevance 0.17 Pain Relevance 0.36
Administration of other compounds that enhance GABA binding (Saffan and diazepam) also significantly enhanced survival time.
Positive_regulation (enhance) of GABA Binding (binding) of associated with gaba
3) Confidence 0.41 Published 1990 Journal J. Neurosurg. Section Abstract Doc Link 2157827 Disease Relevance 0.27 Pain Relevance 0.49
The increased GABA receptor binding in the cerebral cortex of HOPA treated rats was due to the increased affinity of the binding sites.
Positive_regulation (increased) of GABA Binding (binding) of in cerebral cortex associated with gaba receptor and cerebral cortex
4) Confidence 0.32 Published 1985 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2985852 Disease Relevance 0 Pain Relevance 0.93
Repeated injection of HOPA (250 mg/kg/day for 7 consecutive days) increased GABA receptor binding by 53% in the cerebral cortex, while GABA binding in the rest of the forebrain did not change.
Positive_regulation (increased) of GABA Binding (binding) of in forebrain associated with gaba, gaba receptor and cerebral cortex
5) Confidence 0.32 Published 1985 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2985852 Disease Relevance 0 Pain Relevance 0.92
On the contrary, starting from a GABA concentration of 30 ?
Positive_regulation (starting) of GABA Binding (concentration) of associated with gaba
6) Confidence 0.22 Published 2007 Journal The Journal of Physiology Section Body Doc Link PMC2375456 Disease Relevance 0 Pain Relevance 0.56
Clonidine caused a marked enhancement of specific [3H]GABA binding in the hypothalamus.
Positive_regulation (caused) of GABA Binding (binding) of in hypothalamus associated with gaba and clonidine
7) Confidence 0.19 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1650699 Disease Relevance 0.07 Pain Relevance 0.85
Diazepam (10-1000 nM) enhanced the binding of [3H]GABA and of the monocyclic GABA agonist [3H]muscimol, but failed to alter binding of the bicyclic GABA agonist [3H]THIP to fresh, well washed rat brain membranes incubated at 2 degrees C.
Neg (failed) Positive_regulation (enhanced) of GABA Binding (binding) of in brain associated with gaba and agonist
8) Confidence 0.18 Published 1983 Journal Neurosci. Lett. Section Abstract Doc Link 6314189 Disease Relevance 0 Pain Relevance 0.40
Allopregnanolone caused the greatest increase in muscimol binding to uterine GABA(A) receptors at 19.5 days gestation and the least increase during labor, a time when pi and alpha(1) receptor subunit mRNA concentrations were low, and delta and alpha(2) receptor subunit mRNA concentrations were high.
Positive_regulation (increase) of GABA Binding (binding) of in uterine associated with gaba
9) Confidence 0.16 Published 2001 Journal Endocrinology Section Abstract Doc Link 11316740 Disease Relevance 0 Pain Relevance 0.52
positive motivation bias; GABA ?
Positive_regulation (motivation) of GABA Binding (bias) of associated with gaba
10) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887893 Disease Relevance 0.06 Pain Relevance 0.40

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