INT126031

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 40
Total Number 41
Disease Relevance 22.71
Pain Relevance 9.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
Anatomy Link Frequency
endothelial cells 4
neutrophils 4
lymph node 2
stroma 2
plasma 2
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 1075 100.00 Very High Very High Very High
cytokine 418 100.00 Very High Very High Very High
methotrexate 2 99.70 Very High Very High Very High
Inflammation 488 99.04 Very High Very High Very High
sodium channel 5 97.20 Very High Very High Very High
Arthritis 95 96.60 Very High Very High Very High
rheumatoid arthritis 26 96.60 Very High Very High Very High
COX-2 inhibitor 94 92.56 High High
imagery 44 91.84 High High
Central nervous system 29 91.28 High High
Disease Link Frequency Relevance Heat
Adenocarcinoma 62 99.98 Very High Very High Very High
Asthma 105 99.90 Very High Very High Very High
Nasopharynx Cancer 145 99.64 Very High Very High Very High
Disease 286 99.62 Very High Very High Very High
Fibrosarcoma 25 99.60 Very High Very High Very High
Wound Healing 37 99.36 Very High Very High Very High
Major Depressive Disorder 25 99.32 Very High Very High Very High
Glioblastoma 7 99.24 Very High Very High Very High
Breast Cancer 53 99.08 Very High Very High Very High
INFLAMMATION 541 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, when we blocked the capability of PI3K to generate PIP3 in MonoMac 6 cells by Ly 294002 (a specific inhibitor of PI3K), MMP-9 production was inhibited in both AA and PMA stimulated cells.
Negative_regulation (inhibited) of Gene_expression (production) of MMP-9
1) Confidence 0.57 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.07 Pain Relevance 0
This protease was shown to degrade and inactivate 15-PGDH suggesting that elevation of 15-PGDH levels could be due to inhibition of MMP-9 expression by these inhibitors.
Negative_regulation (inhibition) of Gene_expression (expression) of MMP-9
2) Confidence 0.56 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.47 Pain Relevance 0.40
Zymography demonstrated: (a) expression of MMP-2 and MMP-9 activity was downregulated along with elevated dose of indomethacin.
Negative_regulation (downregulated) of Gene_expression (expression) of MMP-9
3) Confidence 0.46 Published 2005 Journal J. Neurooncol. Section Abstract Doc Link 15803368 Disease Relevance 0.30 Pain Relevance 0.19
Relations between plasma MMP-9 levels and total load of risk factors
Negative_regulation (Relations) of Gene_expression (levels) of MMP-9 in plasma
4) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258002 Disease Relevance 0.20 Pain Relevance 0
Serosa invasion, lymph node status, TNM stages, recurrence status and distant metastasis were the variables investigated in this study, all of which were not related to the level of MMP9 and IV collagen, but IV collagen expression was significantly decreased in older patients (P = 0.042).
Negative_regulation (decreased) of Gene_expression (expression) of MMP9 in lymph node associated with metastasis and recurrence
5) Confidence 0.39 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 1.04 Pain Relevance 0
Even though some of the BAL macrophages displayed a very weak expression of MMP-9 immunoreactivity, as has previously been reported in a different inflammatory setting [29], we found the most pronounced increase in and expression of MMP-9 immunoreactivity consistently among BAL neutrophils.
Negative_regulation (displayed) of Gene_expression (expression) of MMP-9 in neutrophils associated with inflammation and metalloproteinase
6) Confidence 0.37 Published 2005 Journal Respir Res Section Body Doc Link PMC1166577 Disease Relevance 0.10 Pain Relevance 0.29
According to Sobrin et al, MMP-3 independently activated MMP-9 on the ocular surface, and doxycycline decreased MMP-9 activity in corneal epithelial cultures.8 Zylberberg et al found that both pro-MMP-2 and pro-MMP-9 were secreted by the lacrimal gland, and were likely up-regulated by estrogen.19 Kobayashi reported that leptomycin B reduced MMP-9 expression.4 During corneal wound healing, transforming growth factor-?
Negative_regulation (reduced) of Gene_expression (expression.4) of MMP-9 in lacrimal gland associated with disorders of the lacrimal system and wound healing
7) Confidence 0.37 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2915870 Disease Relevance 0.72 Pain Relevance 0.20
Similarly, flurbiprofen was also demonstrated to inhibit ERK activation and to down-regulate MMP-9 expression.
Negative_regulation (down-regulate) of Gene_expression (expression) of MMP-9
8) Confidence 0.36 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.40 Pain Relevance 0.29
plus methotrexate significantly decreases serum IL-18, E-selectin, TIMP1 and MMP9 levels [53].
Negative_regulation (decreases) of Gene_expression (levels) of MMP9 associated with methotrexate
9) Confidence 0.34 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.54 Pain Relevance 0.22
In addition, 9 cases of PDAC demonstrated strong MMP-9 expression in the stroma.
Negative_regulation (demonstrated) of Gene_expression (expression) of MMP-9 in stroma associated with adenocarcinoma
10) Confidence 0.34 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.26 Pain Relevance 0
Further more, GC patients with negative MMP9 expression displayed improved overall survival compared to patients with positive MMP9 expression (Median OS was 44.0 and 13.5 months, respectively.
Negative_regulation (positive) of Gene_expression (expression) of MMP9 associated with stomach cancer
11) Confidence 0.34 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 1.31 Pain Relevance 0.10
Based on these findings, we postulate the notion that decreased Rho signaling by BPs could be responsible for the reduced surface expression of CD44, surface interaction of CD44/MMP-9, and cell migration (Figures 4 and 5) in PC3 and PC3/OPN cells.
Negative_regulation (reduced) of Gene_expression (expression) of MMP-9
12) Confidence 0.32 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.11 Pain Relevance 0.14
Miralles et al (1999) have shown that indomethacin attenuates aneurysm growth and its effects are mediated via inhibition of the cox2 isoform, which decreases PGE2 and MMP-9 synthesis.
Negative_regulation (decreases) of Gene_expression (synthesis) of MMP-9 associated with aneurism
13) Confidence 0.32 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993941 Disease Relevance 0.19 Pain Relevance 0.22
Protein expression levels of both MMP-9 and MMP-2 were inhibited and TIMP-1 protein level was enhanced by these flavonoid glycosides [33].
Negative_regulation (inhibited) of Gene_expression (levels) of MMP-9
14) Confidence 0.31 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.21 Pain Relevance 0.11
RESULTS: Gelatin zymography showed that all NSAIDs generally decreased MMP-2 secretion in chondral, meniscal and synovial cultures as well as MMP-9 production in meniscal and synovial cultures.
Negative_regulation (decreased) of Gene_expression (production) of MMP-9
15) Confidence 0.28 Published 2008 Journal Clin. Biochem. Section Body Doc Link 17996201 Disease Relevance 0.09 Pain Relevance 0
It was also found that COS-I was capable of inhibiting both gene and protein expression of MMP-9 (P<0.01) [26].
Negative_regulation (inhibiting) of Gene_expression (expression) of MMP-9
16) Confidence 0.27 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.09 Pain Relevance 0.03
Transfection studies carried out with MMP-9 and AP-1 reporter constructs suggested that the observed reduction in MMP-9 expression was due to down-regulation of MMP-9 transcription which mediated via inhibition of AP-1.
Negative_regulation (reduction) of Gene_expression (expression) of MMP-9
17) Confidence 0.27 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.25 Pain Relevance 0.10
Also, although the expression level of MMP-9 is not indicative of the NPA found in SF, MMPs contribute to a large extent to the proteolytic activity.
Negative_regulation (level) of Gene_expression (expression) of MMP-9 associated with metalloproteinase
18) Confidence 0.23 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779417 Disease Relevance 0.48 Pain Relevance 0.40
At the same time point after the exposure, the MMP-9 expression in neutrophils was associated with an increase in mRNA for IL-17A, even though the fraction (percentage) of neutrophils expressing MMP-9 was not increased.
Negative_regulation (associated) of Gene_expression (expression) of MMP-9 in neutrophils associated with metalloproteinase
19) Confidence 0.23 Published 2005 Journal Respir Res Section Body Doc Link PMC1166577 Disease Relevance 0.09 Pain Relevance 0.31
In order to correct for a passive transfer of MMP-9 and CxCL-13 we calculated a ratio using the following formula: MMP-9 ratio?
Negative_regulation (passive) of Gene_expression (transfer) of MMP-9 associated with metalloproteinase
20) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.40 Pain Relevance 0.58

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