INT126036

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.28
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Smc2) nuclear chromosome (Smc2) chromosome organization (Smc2)
chromosome (Smc2) nucleus (Smc2) cell cycle (Smc2)
Anatomy Link Frequency
livers 1
Smc2 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 7 95.36 Very High Very High Very High
analgesia 14 68.44 Quite High
Lasting pain 4 52.64 Quite High
Analgesic 10 52.00 Quite High
cytokine 6 51.24 Quite High
Glutamate receptor 14 50.00 Quite Low
tricyclic antidepressant 2 38.60 Quite Low
carbamazepine 2 27.72 Quite Low
anticonvulsant 4 25.96 Quite Low
Neuropathic pain 10 19.40 Low Low
Disease Link Frequency Relevance Heat
Stress 3 98.00 Very High Very High Very High
Stress Incontinence 1 81.44 Quite High
Pain 14 52.64 Quite High
Syndrome 2 19.80 Low Low
Neuropathic Pain 10 19.40 Low Low
Nervous System Injury 4 14.76 Low Low
Targeted Disruption 24 10.72 Low Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunostaining showed changes (e.g. increased expression of FGF2 protein in the outer nuclear layer) suggesting a retinal stress reaction to high-energy particles of potential relevance in space.
Gene_expression (expression) of FGF2 protein associated with stress
1) Confidence 0.65 Published 2004 Journal Adv Space Res Section Abstract Doc Link 15803626 Disease Relevance 0.18 Pain Relevance 0.10
Notably, c-Met inactivation affected expression of genes involved in chromosome congression, alignment and segregation (Esco2, SMC2, Nuf2).
Gene_expression (expression) of SMC2
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0.03
Accordingly, microarray profiling of c-Met deficient regenerating livers revealed downregulation of genes known to control chromosome congression, alignment and segregation (Esco2, CENPs, SMC2, Nuf1, etc.) along with others implicated in spindle organization and biogenesis (Ect2, ASPM, Nusap1, and Stmn1, 3 and 4).
Gene_expression (segregation) of SMC2 in livers
3) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0
CAPE (Calbiochem) was dissolved in DMSO, stored at -20°C and diluted in culture growth media to a final concentration of 2.5 ?
Gene_expression (diluted) of CAPE
4) Confidence 0.11 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0.05 Pain Relevance 0.17
CAPE (Calbiochem) was dissolved in DMSO, stored at -20°C and diluted in culture growth media to a final concentration of 2.5 ?
Gene_expression (dissolved) of CAPE
5) Confidence 0.11 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0.05 Pain Relevance 0.17

General Comments

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