INT126047

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 5.05
Pain Relevance 5.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
spinal cord 3
spinal 2
spinal nerve 2
glial cell 2
peripheral nervous system 2
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 14 100.00 Very High Very High Very High
noradrenaline 11 100.00 Very High Very High Very High
Brush evoked pain 4 100.00 Very High Very High Very High
ischemia 104 99.84 Very High Very High Very High
Perioperative pain 42 99.84 Very High Very High Very High
Spinal cord 51 99.68 Very High Very High Very High
Inflammation 46 99.00 Very High Very High Very High
allodynia 63 98.52 Very High Very High Very High
Neuritis 7 98.44 Very High Very High Very High
Eae 19 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 142 100.00 Very High Very High Very High
Cv Unclassified Under Development 77 99.84 Very High Very High Very High
Post Operative Pain 44 99.84 Very High Very High Very High
Diabetes Mellitus 135 99.68 Very High Very High Very High
INFLAMMATION 54 99.00 Very High Very High Very High
Experimental Autoimmune Neuritis 6 98.44 Very High Very High Very High
Frailty 2 95.60 Very High Very High Very High
Autoimmune Disease 2 95.28 Very High Very High Very High
Cold Sores 2 87.20 High High
Nervous System Injury 17 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, we postulate that the phosphorylation of p38 MAPK is involved in the elimination of infiltrating inflammatory cells during the course of EAN and may possibly modulate recovery in autoimmune disorders of the peripheral nervous system.
Regulation (involved) of Phosphorylation (phosphorylation) of p38 in peripheral nervous system associated with autoimmune disease, peripheral nervous system, inflammation and neuritis
1) Confidence 0.60 Published 2005 Journal Brain Res. Section Abstract Doc Link 15804444 Disease Relevance 1.03 Pain Relevance 0.98
This study examined effects of age (young rats, approximately 35 days, vs mature rats, approximately 75-110 days) on spinal nerve ligation (SNL)-induced tactile allodynia and phosphorylation of p38 (as measured by phospho-p38 MAP kinase [P-p38]) in dorsal root ganglia and spinal cord.
Spec (examined) Regulation (effects) of in dorsal root ganglia Phosphorylation (phosphorylation) of p38 in spinal nerve associated with brush evoked pain, spinal nerve ligature and spinal cord
2) Confidence 0.42 Published 2006 Journal J Pain Section Abstract Doc Link 16632323 Disease Relevance 0.33 Pain Relevance 0.78
To elucidate the involvement of the noradrenergic system in the regulation of spinal microglial activity, we examined the effects of noradrenaline (NA) on the phosphorylation of three MAP kinases (extracellular signal-regulated kinase (ERK), p38, or c-Jun N-terminal kinase (JNK)) stimulated by ATP in rat cultured spinal microglia using Western blotting.
Spec (examined) Regulation (effects) of Phosphorylation (phosphorylation) of p38 in spinal associated with noradrenaline
3) Confidence 0.39 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19524113 Disease Relevance 0 Pain Relevance 0.26
These animals were used to provide spinal cord tissue for the analysis of GFAP expression and p38 phosphorylation.
Regulation (analysis) of Phosphorylation (phosphorylation) of p38 in spinal cord associated with spinal cord
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0 Pain Relevance 0.30
The expression of phosphorylated p38 protein and mRNA was not affected by ischemia, according to immunofluorescence, western blot, or real-time PCR analysis (Figure 8 and Figure 9).
Neg (not) Regulation (affected) of Phosphorylation (phosphorylated) of p38 associated with ischemia
5) Confidence 0.15 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 0.50 Pain Relevance 0.28
This study examined effects of age (young rats, approximately 35 days, vs mature rats, approximately 75-110 days) on spinal nerve ligation (SNL)-induced tactile allodynia and phosphorylation of p38 (as measured by phospho-p38 MAP kinase [P-p38]) in dorsal root ganglia and spinal cord.
Spec (examined) Regulation (effects) of in spinal cord Phosphorylation (phosphorylation) of p38 in spinal nerve associated with brush evoked pain, spinal nerve ligature and spinal cord
6) Confidence 0.14 Published 2006 Journal J Pain Section Abstract Doc Link 16632323 Disease Relevance 0.33 Pain Relevance 0.78
Similar but opposing effect observed in p38 phosphorylation where significantly less phosphorylation occurred in resveratrol or longevinex treated BL samples.
Regulation (effect) of Phosphorylation (phosphorylation) of p38
7) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009730 Disease Relevance 0.24 Pain Relevance 0.03
Using this approach, we demonstrated that ECB signaling plays a functional role in the resolution of postoperative pain and in regulating the expression of glial cell markers and phosphorylated p38 (a MAPK associated with inflammation [18]).


Regulation (regulating) of Phosphorylation (phosphorylated) of p38 in glial cell associated with inflammation and perioperative pain
8) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.87 Pain Relevance 0.92
and p38 phosphorylation; treatment with inhibitors of either TNF-?
Regulation (treatment) of Phosphorylation (phosphorylation) of p38
9) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2861665 Disease Relevance 0.88 Pain Relevance 0.65
Duration of streptozotocin-induced diabetes differentially affects p38-mitogen-activated protein kinase (MAPK) phosphorylation in renal and vascular dysfunction

Background

Regulation (affects) of Phosphorylation (phosphorylation) of p38-mitogen-activated associated with diabetes mellitus
10) Confidence 0.09 Published 2005 Journal Cardiovasc Diabetol Section Title Doc Link PMC555576 Disease Relevance 0.86 Pain Relevance 0.03

General Comments

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