INT126060

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.14
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4) plasma membrane (Cxcr4)
signal transducer activity (Cxcr4)
Anatomy Link Frequency
bone marrow 4
bladder 4
cervix 3
neuronal 2
satellite cells 2
Cxcr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 242 100.00 Very High Very High Very High
dorsal root ganglion 58 96.76 Very High Very High Very High
Demyelination 49 96.44 Very High Very High Very High
MU agonist 2 85.40 High High
Enkephalin 1 83.56 Quite High
Pain 21 80.80 Quite High
hyperexcitability 6 80.44 Quite High
cytokine 33 78.84 Quite High
Opioid 4 75.68 Quite High
gABA 2 74.00 Quite High
Disease Link Frequency Relevance Heat
Stress Incontinence 4 97.88 Very High Very High Very High
Myeloid Leukemia 18 97.48 Very High Very High Very High
Ganglion Cysts 59 96.76 Very High Very High Very High
Demyelinating Disease 51 96.44 Very High Very High Very High
Cancer 5 89.08 High High
Pain 43 80.80 Quite High
Bladder Cancer 12 78.92 Quite High
Chronic Myeloid Leukemia 4 75.00 Quite High
Malignant Neoplastic Disease 4 75.00 Quite High
Nervous System Injury 36 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclophosphamide upregulated bladder CXCR4 expression: MIF-CXCR4 associations in the bladder
Negative_regulation (Cyclophosphamide) of Gene_expression (expression) of CXCR4 in bladder
1) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
There is also evidence of CXCR4 mRNA expression in other areas of the human urogenital system (e.g. urethra, cervix) [28].
Negative_regulation (evidence) of Gene_expression (expression) of CXCR4 mRNA in cervix associated with stress incontinence
2) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.34 Pain Relevance 0
Cyclophosphamide upregulated bladder CXCR4 expression: MIF-CXCR4 associations in the bladder
Negative_regulation (bladder) of Gene_expression (expression) of CXCR4 in bladder
3) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
Notably satellite cells under these conditions lacked both CXCR4 mRNA transcripts and protein expression (Fig. 4E, F).
Negative_regulation (lacked) of Gene_expression (expression) of CXCR4 mRNA in satellite cells
4) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.29 Pain Relevance 0.18
Basal expression of CXCR4 mRNA was predominantly detected in non-neuronal cells of the lumbar DRG derived from naïve animals (data not shown).
Negative_regulation (detected) of Gene_expression (expression) of CXCR4 mRNA in neuronal
5) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.39 Pain Relevance 0.41
There is also evidence of CXCR4 mRNA expression in other areas of the human urogenital system (e.g. urethra, cervix) [28].
Negative_regulation (evidence) of in urethra Gene_expression (expression) of CXCR4 mRNA in cervix associated with stress incontinence
6) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.34 Pain Relevance 0
Similarly, pretreatment with cycloheximide prevented CCL5 or CXCR4 mRNA expression, consistent with the observation that DAMGO induction of chemokine and chemokine receptor expression requires newly synthesized TGF-beta1 protein.
Negative_regulation (prevented) of Gene_expression (expression) of CXCR4 associated with chemokine
7) Confidence 0.09 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18252865 Disease Relevance 0 Pain Relevance 0.88
Decreased expression of junction plakoglobulin and CXC chemokine receptor 4 (CXCR-4) might facilitate the release of immature precursors from bone marrow in CML.
Negative_regulation (Decreased) of Gene_expression (expression) of CXC chemokine receptor 4 in bone marrow associated with chemokine and myeloid leukemia
8) Confidence 0.06 Published 2005 Journal Oncogene Section Abstract Doc Link 15806158 Disease Relevance 0.89 Pain Relevance 0.26
Decreased expression of junction plakoglobulin and CXC chemokine receptor 4 (CXCR-4) might facilitate the release of immature precursors from bone marrow in CML.
Negative_regulation (Decreased) of Gene_expression (expression) of CXCR-4 in bone marrow associated with chemokine and myeloid leukemia
9) Confidence 0.06 Published 2005 Journal Oncogene Section Abstract Doc Link 15806158 Disease Relevance 0.89 Pain Relevance 0.26

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