INT12608

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Context Info
Confidence 0.60
First Reported 1991
Last Reported 2010
Negated 2
Speculated 12
Reported most in Abstract
Documents 62
Total Number 74
Disease Relevance 24.36
Pain Relevance 36.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (CNR1) plasma membrane (CNR1) response to stress (CNR1)
signal transducer activity (CNR1)
Anatomy Link Frequency
brain 5
sensory nerves 2
neurons 2
macrophages 1
ileum 1
CNR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid 766 100.00 Very High Very High Very High
Cannabinoid receptor 239 100.00 Very High Very High Very High
agonist 170 100.00 Very High Very High Very High
antagonist 151 100.00 Very High Very High Very High
Pain 110 100.00 Very High Very High Very High
Opioid 54 100.00 Very High Very High Very High
Nicotine 28 100.00 Very High Very High Very High
orphanin 12 100.00 Very High Very High Very High
Endocannabinoid 347 99.92 Very High Very High Very High
anesthesia 4 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sepsis 11 100.00 Very High Very High Very High
Targeted Disruption 8 100.00 Very High Very High Very High
Ileus 4 100.00 Very High Very High Very High
Vomiting 274 99.80 Very High Very High Very High
Disease 348 99.76 Very High Very High Very High
Cancer 556 99.64 Very High Very High Very High
Pain 109 99.36 Very High Very High Very High
Heart Rate Under Development 22 99.32 Very High Very High Very High
Nervous System Injury 6 98.88 Very High Very High Very High
Nociception 10 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of CB1 receptors are key to the analgesic effects of cannabinoids in both chronic and neuropathic pain, and CB2 receptors also appear to play an important role (Croxford 2003).
Regulation (regulation) of CB1 associated with cannabinoid, analgesic and neuropathic pain
1) Confidence 0.60 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503671 Disease Relevance 1.89 Pain Relevance 1.24
The data demonstrate the existence of multiple pathways of CB1 receptors regulation.
Regulation (regulation) of CB1
2) Confidence 0.60 Published 2003 Journal Brain Res. Section Abstract Doc Link 12867259 Disease Relevance 0.08 Pain Relevance 0.21
Multiple mechanisms of CB1 cannabinoid receptors regulation.
Regulation (regulation) of CB1 associated with cannabinoid receptor and cannabinoid
3) Confidence 0.60 Published 2003 Journal Brain Res. Section Title Doc Link 12867259 Disease Relevance 0.09 Pain Relevance 0.33
Regulation of cannabinoid CB1 receptors in the central nervous system by chronic cannabinoids.
Regulation (Regulation) of CB1 in central nervous system associated with cannabinoid and central nervous system
4) Confidence 0.60 Published 2003 Journal Crit Rev Neurobiol Section Title Doc Link 14977366 Disease Relevance 0.09 Pain Relevance 0.59
This scenario has been demonstrated also for CBRs, since several stimuli have been reported to differently modulate both cannabinoid receptor subtypes in immune cells, like mouse splenocytes, Jurkat T-cells, mouse macrophages and microglia, as well as human tonsillar B cells and dendritic cells [8].
Spec (like) Regulation (modulate) of cannabinoid receptor in microglia associated with cannabinoid receptor
5) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0.08 Pain Relevance 0.27
Agonist-induced regulation of cannabinoid CB1 receptors was examined in HEK-293 cells transfected with CB1 receptors and in neuroblastoma N18TG2 cells that naturally express CB1 receptors.
Regulation (regulation) of CB1 in N18TG2 associated with neuroblastoma, cannabinoid and agonist
6) Confidence 0.44 Published 2003 Journal Brain Res. Section Abstract Doc Link 12867259 Disease Relevance 0.10 Pain Relevance 0.20
In addition, activating CBII receptors may result in an increase in proliferation and affect migration of NPCs.
Regulation (affect) of CBI
7) Confidence 0.44 Published 2010 Journal Cent Nerv Syst Agents Med Chem Section Abstract Doc Link 20236042 Disease Relevance 1.00 Pain Relevance 0.50
We evaluated the effects of the cannabinoid receptor antagonist SR 141716A (N-piperidino-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-3-pyrazolecarboxamide) on mouse hot plate latencies.
Regulation (effects) of cannabinoid receptor associated with cannabinoid receptor and antagonist
8) Confidence 0.42 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9042616 Disease Relevance 0.40 Pain Relevance 0.69
We studied the effect of cannabinoid receptor agonists anandamide and WIN 55,212-2 on the central pain syndrome induced by intraspinal injection of penicillin sodium salt in rats.
Regulation (effect) of cannabinoid receptor associated with complex regional pain syndromes, central pain, cannabinoid receptor and agonist
9) Confidence 0.37 Published 2006 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 17369898 Disease Relevance 0.34 Pain Relevance 0.88
In addition, the treatments, mainly the 5-ASA+corticosteroids one, lead to a chronic down-regulation of CB1 receptor (not displayed acutely), probably reflecting a diminished colonic functionality in the chronic state of the disease, since CB1 receptor have been implicated in colonic motility and secretion.[27], [39] Thus, cannabinoid CB1 receptor could be a biological marker of UC progression.
Regulation (regulation) of CB1 receptor associated with inflammatory bowel disease, corticosteroid, cannabinoid and disease
10) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.74 Pain Relevance 0.28
Examination of the effect of the cannabinoid receptor agonist, CP 55,940, on electrically evoked transmitter release from rat brain slices.
Regulation (effect) of cannabinoid receptor in brain associated with cannabinoid receptor, analgesic and agonist
11) Confidence 0.35 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9145770 Disease Relevance 0 Pain Relevance 0.47
In the present study we examined the effect of the cannabinoid receptor agonist, [[1 a,2-(R)-5-(1,1-dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyc lohexyl]-phenol; CP 55,940] on [14C]acetylcholine and [3H]norepinephrine release from hippocampal slices and on [14C]acetylcholine release from striatal slices.
Spec (examined) Regulation (effect) of cannabinoid receptor associated with cannabinoid receptor and agonist
12) Confidence 0.35 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9145770 Disease Relevance 0 Pain Relevance 0.23
Hence, the endocannabinoid system, including the CB1 and CB2 receptors, the metabolizing enzyme fatty acid amide hydrolase and the anandamide transporter, is a potential target for the development of novel therapeutic drugs in the treatment of various conditions, such as pain, feeding disorders and vascular disease among others.
Regulation (target) of CB1 associated with pain, endocannabinoid and increased venous pressure under development
13) Confidence 0.34 Published 2003 Journal Curr Vasc Pharmacol Section Abstract Doc Link 15320476 Disease Relevance 0.63 Pain Relevance 0.63
Depolarization and Ca(2+) down regulate CB1 receptors and CB1-mediated signaling in cerebellar granule neurons.
Regulation (regulate) of CB1 in neurons
14) Confidence 0.33 Published 2006 Journal Neuropharmacology Section Title Doc Link 16412482 Disease Relevance 0 Pain Relevance 0.56
Recent developments have implicated cannabinoid CB1 receptors as a novel target for a new class of therapeutic agents used to treat drug addiction.
Regulation (target) of CB1 associated with drug dependence, addiction and cannabinoid
15) Confidence 0.27 Published 2005 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 15992935 Disease Relevance 0.25 Pain Relevance 0.26
CB1 receptors are therefore valid targets for antiemetic effects in patients with CINV.
Regulation (targets) of CB1 associated with vomiting
16) Confidence 0.26 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503671 Disease Relevance 1.64 Pain Relevance 0.21
Using a cutoff CB1IR value of ?
Regulation (value) of CB1IR
17) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.22 Pain Relevance 0.03
The data presented here indicate that the degree to which FAAH is associated with disease severity and outcome are dependent upon the prevailing CB1IR.
Regulation (dependent) of CB1IR associated with disease
18) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.39 Pain Relevance 0.03
In this work we characterized the effect of the new cannabinoid receptor antagonist, SR-141,716 A (N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3- pyrazolecarboxamide hydrochloride), on delta 9-tetrahydrocannabinol-induced analgesia. pA2 values in the tail-flick and in lick and jump responses in the hot-plate tests were 9.59, 8.72 and 10.21, respectively.
Regulation (effect) of cannabinoid receptor in tail associated with cannabinoid receptor, antagonist, tail-flick and analgesia
19) Confidence 0.26 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8773449 Disease Relevance 0.10 Pain Relevance 1.03
CB1-R immunoreactivity was observed in the myenteric and submucosal ganglionated plexuses of porcine ileum and colon.
Regulation (immunoreactivity) of CB1-R in colon
20) Confidence 0.26 Published 2000 Journal Cell Tissue Res. Section Abstract Doc Link 11079717 Disease Relevance 0.08 Pain Relevance 0.16

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