INT126099

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 5.72
Pain Relevance 4.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc12a5) plasma membrane (Slc12a5) intracellular (Slc12a5)
transmembrane transport (Slc12a5)
Anatomy Link Frequency
neurons 5
dorsal root ganglia 1
dorsal horn 1
Slc12a5 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 24 99.84 Very High Very High Very High
Neuropathic pain 3 99.72 Very High Very High Very High
gABA 96 99.52 Very High Very High Very High
allodynia 240 97.36 Very High Very High Very High
Dorsal horn neuron 3 97.24 Very High Very High Very High
Lasting pain 3 96.28 Very High Very High Very High
Neurotransmitter 33 94.92 High High
hyperexcitability 3 93.24 High High
potassium channel 3 92.04 High High
GABAergic 106 88.56 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 25 99.84 Very High Very High Very High
Neuropathic Pain 243 99.72 Very High Very High Very High
Stress 72 99.08 Very High Very High Very High
Targeted Disruption 42 98.32 Very High Very High Very High
Injury 6 96.88 Very High Very High Very High
Pain 34 96.28 Very High Very High Very High
Epilepsy 7 94.92 High High
Hypersensitivity 6 94.08 High High
Motor Neuron Diseases 321 93.68 High High
Death 57 93.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A major effector of this task in adult animals is the potassium-chloride co-transporter KCC2 that is selectively and abundantly expressed postsynaptically in most CNS neurons.
Gene_expression (expressed) of KCC2 in neurons
1) Confidence 0.77 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15813942 Disease Relevance 0.12 Pain Relevance 0
Immunohistochemistry showed that a major fraction of neurons in the dorsal root ganglia express the cation-chloride co-transporters NKCC1 and KCC2, indicating that the molecular equipment for Cl(-) accumulation and extrusion is present.
Gene_expression (express) of KCC2 in dorsal root ganglia
2) Confidence 0.73 Published 2007 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 17869474 Disease Relevance 0.22 Pain Relevance 0.32
Indeed, down-regulation of SLC12A5 expression together with GABAA receptor-mediated excitation occurs after in-vivo axonal injury [31], and mouse SLC12A5 knockouts suffer severe motor deficits and immediate postnatal death by asphyxiation [32].
Gene_expression (expression) of SLC12A5 associated with injury and death
3) Confidence 0.55 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.79 Pain Relevance 0.22
During early development, increased expression of SLC12A5 lowers the intraneuronal chloride concentration below its electrochemical equilibrium and allows GABA to act as an inhibitory neurotransmitter.
Gene_expression (expression) of SLC12A5 associated with neurotransmitter and gaba
4) Confidence 0.55 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.51 Pain Relevance 0.23
Increased excitability, and hence exacerbated excitotoxicity, may also derive from the reduced expression of ATP1A3, KCNC2, and SLC12A5.
Gene_expression (expression) of SLC12A5
5) Confidence 0.55 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.36 Pain Relevance 0.04
Inhibition of KCC2 by BUM would be expected to have the opposite effect on touch-evoked responses because decreased KCC2 expression (analogous to pharmacological inhibition) or KCC2 blockade with DIOA reverses the polarity of GABAAR responses in a subset of lamina I and II neurons, leading to allodynia which has been proposed as a mechanism of neuropathic pain [28].
Gene_expression (expression) of KCC2 in neurons associated with allodynia and neuropathic pain
6) Confidence 0.39 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 0.86 Pain Relevance 0.92
Inhibition of KCC2 by BUM would be expected to have the opposite effect on touch-evoked responses because decreased KCC2 expression (analogous to pharmacological inhibition) or KCC2 blockade with DIOA reverses the polarity of GABAAR responses in a subset of lamina I and II neurons, leading to allodynia which has been proposed as a mechanism of neuropathic pain [28].
Gene_expression (expression) of KCC2 in neurons associated with allodynia and neuropathic pain
7) Confidence 0.39 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 0.84 Pain Relevance 0.85
KCC2 is not expressed by DRG neurons [29] so this consideration applies only to intrinsic dorsal horn neurons.
Neg (not) Gene_expression (expressed) of KCC2 in dorsal horn associated with dorsal root ganglion and dorsal horn neuron
8) Confidence 0.39 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 0.97 Pain Relevance 0.96
Cortical neurons from KCC2 knock out mice exhibit an abnormal morphology of dendritic spines that can be rescued by overexpression of a transport inactive mutant of KCC2.
Gene_expression (overexpression) of KCC2 in neurons associated with targeted disruption
9) Confidence 0.23 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.50 Pain Relevance 0.15
Surface expression and fast changes in the activity of KCC2 like during oxidative stress are mediated by regulating the phosphorylation state of KCC2 (Lee et al., 2007; Wake et al., 2007).
Gene_expression (expression) of KCC2 associated with stress
10) Confidence 0.20 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.55 Pain Relevance 0.22
Most neurons have a high intracellular Cl-concentration early in life due to the late functional expression of the Cl-pump KCC2, therefore GABA has excitatory effects at this stage.
Gene_expression (expression) of KCC2 in neurons associated with gaba
11) Confidence 0.18 Published 2008 Journal Frontiers in Molecular Neuroscience Section Abstract Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.45

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