INT1261

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Context Info
Confidence 0.81
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 63
Total Number 63
Disease Relevance 19.36
Pain Relevance 16.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adh1) mitochondrion (Adh1) oxidoreductase activity (Adh1)
intracellular (Adh1) embryo development (Adh1) cytoplasm (Adh1)
Anatomy Link Frequency
blood 6
cardiovascular system 6
heart 5
plasma 4
Urine 2
Adh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 57 99.92 Very High Very High Very High
Clonidine 84 99.78 Very High Very High Very High
Pain 12 99.62 Very High Very High Very High
depression 4 99.58 Very High Very High Very High
anesthesia 14 99.42 Very High Very High Very High
antagonist 19 99.36 Very High Very High Very High
fluoxetine 3 99.16 Very High Very High Very High
butorphanol 12 98.94 Very High Very High Very High
headache 2 96.72 Very High Very High Very High
medulla 3 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperplasia 26 100.00 Very High Very High Very High
Stress 9 100.00 Very High Very High Very High
Volume Depletion And Dehydration 9 99.84 Very High Very High Very High
Diuresis 41 99.70 Very High Very High Very High
Pressure Volume 2 Under Development 31 99.70 Very High Very High Very High
Convulsion 2 99.68 Very High Very High Very High
Syndrome 4 99.64 Very High Very High Very High
Pain 9 99.62 Very High Very High Very High
Depression 4 99.58 Very High Very High Very High
Hyponatremia 6 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Butorphanol prevented the expected rise in urine osmolality and ADH excretion due to 31 h of dehydration.
Localization (excretion) of ADH in urine associated with volume depletion and dehydration and butorphanol
1) Confidence 0.81 Published 1975 Journal Neuroendocrinology Section Abstract Doc Link 1223660 Disease Relevance 0.18 Pain Relevance 0.52
The data indicate that these narcotic antagonists cause a diuresis by inhibiting ADH release from the neurohypophysis.
Localization (release) of ADH in neurohypophysis associated with diuresis and antagonist
2) Confidence 0.81 Published 1975 Journal Neuroendocrinology Section Abstract Doc Link 1223660 Disease Relevance 0.26 Pain Relevance 0.48
Clonidine, an alpha adrenergic agonist which causes a diuresis in experimental animals, was studied in unanesthetized, conscious Brattleboro rats heterozygous or homozygous for hereditary hypothalamic diabetes insipidus to determine if the diuresis was due to alpha adrenergic inhibition of antidiuretic hormone (ADH) release or to another mechanism of action.
Localization (release) of ADH associated with diuresis, diabetes insipidus, agonist and clonidine
3) Confidence 0.80 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7400963 Disease Relevance 0.62 Pain Relevance 0.53
Due to water retention and drinking following stimulation of ADH secretion and thirst, osmoregulation is overruled by volume conservatory mechanisms, which lead to hyponatremia.
Localization (secretion) of ADH associated with hyponatremia and pressure and volume under development
4) Confidence 0.79 Published 1993 Journal Schweiz. Rundsch. Med. Prax. Section Abstract Doc Link 8362127 Disease Relevance 0.78 Pain Relevance 0.06
In a 78-year-old female with hyponatraemia, the syndrome of inappropriate ADH secretion as a side effect of fluoxetine, a relatively new antidepressive drug, was tentatively diagnosed.
Localization (secretion) of ADH associated with hyponatremia, syndrome and fluoxetine
5) Confidence 0.79 Published 1994 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 8008142 Disease Relevance 0.27 Pain Relevance 0.29
Peripheral neuropathies, cranial nerve palsies, paralytic ileus, atony of the bladder, hypertension, hypotension, seizures, inappropriate ADH secretion, and severe bone marrow depression were all encountered.
Localization (secretion) of ADH in bone marrow associated with cranial neuropathy, convulsion, pressure volume 2 under development, depression, hypertension, peripheral neuropathy and intestinal pseudo-obstruction
6) Confidence 0.79 Published 1976 Journal J. Pediatr. Section Abstract Doc Link 182948 Disease Relevance 1.28 Pain Relevance 0.25
These results suggest that clonidine-induced diuresis is related to inhibition of vasopressin (ADH) secretion.
Localization (secretion) of ADH associated with diuresis and clonidine
7) Confidence 0.78 Published 1981 Journal J Pharmacol Section Abstract Doc Link 7289624 Disease Relevance 0.41 Pain Relevance 0.94
Volume receptors are situated in many organs and are capable of modulating ADH secretion.
Localization (secretion) of ADH
8) Confidence 0.78 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8884540 Disease Relevance 0.16 Pain Relevance 0.08
Inhibition of ADH release in the rat by narcotic antagonists.
Localization (release) of ADH associated with antagonist
9) Confidence 0.71 Published 1975 Journal Neuroendocrinology Section Title Doc Link 1223660 Disease Relevance 0.16 Pain Relevance 0.50
It is suggested that the antidiuretic effect of morphine may occur independently of ADH release.
Localization (release) of ADH associated with morphine
10) Confidence 0.71 Published 1982 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 7083068 Disease Relevance 0.10 Pain Relevance 0.26
Both norepinephrine and clonidine markedly reduced ADH release and lowered arterial blood pressure and heart rate.
Localization (release) of ADH in heart associated with clonidine
11) Confidence 0.71 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.15 Pain Relevance 0.19
Intravenous isoproterenol lowered blood pressure and increased ADH release and heart rate.
Localization (release) of ADH in heart associated with pressure volume 2 under development
12) Confidence 0.71 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.19 Pain Relevance 0.23
In order to investigate the role of central noradrenergic neurons in the control of vasopressin (ADH) release and cardiovascular regulation, norepinephrine (1.4 microgram/kg), clonidine (0.1 microgram/kg), and isoproterenol (1.4 microgram/kg were infused into the lateral cerebral ventricle of the anesthetized dog.
Localization (release) of ADH in neurons associated with clonidine
13) Confidence 0.71 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.06 Pain Relevance 0.17
It is concluded that, in the anesthetized dog, intraventricular norepinephrine and clonidine decreased ADH release, blood pressure, and heart rate by stimulating alpha-adrenoreceptors.
Localization (release) of ADH in blood associated with clonidine
14) Confidence 0.71 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.17 Pain Relevance 0.23
Thus, clonidine-induced diuresis does not appear to be due to alpha adrenergic inhibition of ADH release but rather to direct renal effects.
Localization (release) of ADH associated with diuresis and clonidine
15) Confidence 0.70 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7400963 Disease Relevance 0.62 Pain Relevance 0.79
This is caused mainly by fluid overload due to excesssive drinking and a release of ADH induced by hypovolemia and stress which impairs the excretion of free water.
Localization (release) of ADH
16) Confidence 0.70 Published 2007 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 17726655 Disease Relevance 0.05 Pain Relevance 0
In the psychic stress, ADH releases at the same time with CRF which intensifies the effects of it.
Localization (releases) of ADH associated with stress
17) Confidence 0.70 Published 1996 Journal Rev Med Chir Soc Med Nat Iasi Section Abstract Doc Link 9455394 Disease Relevance 0.50 Pain Relevance 0.19
The experiment was performed in controlled environmental conditions to avoid pain or stress-related ADH release.
Localization (release) of ADH associated with stress and pain
18) Confidence 0.68 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8884540 Disease Relevance 0.20 Pain Relevance 0.10
Clonidine-induced diuresis was not at least due to the inhibition of ADH release.
Localization (release) of ADH associated with diuresis and clonidine
19) Confidence 0.67 Published 1996 Journal Fundam Clin Pharmacol Section Abstract Doc Link 8900500 Disease Relevance 0.60 Pain Relevance 1.20
Effect of postoperative extradural morphine on ADH secretion.
Localization (secretion) of ADH associated with morphine
20) Confidence 0.66 Published 1985 Journal Br J Anaesth Section Title Doc Link 3986069 Disease Relevance 0 Pain Relevance 0.62

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