INT126114

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Context Info
Confidence 0.07
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.08
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcna7) transmembrane transport (Kcna7)
Anatomy Link Frequency
neuronal 2
Kcna7 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 5 90.00 High High
amygdala 2 89.20 High High
Pain 3 87.12 High High
hyperexcitability 8 86.20 High High
gABA 4 78.24 Quite High
Analgesic 4 70.56 Quite High
anticonvulsant 2 65.52 Quite High
dorsal root ganglion 18 56.24 Quite High
Action potential 3 40.32 Quite Low
diclofenac 28 37.32 Quite Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 16 99.12 Very High Very High Very High
Epilepsy 8 98.92 Very High Very High Very High
Convulsion 12 96.52 Very High Very High Very High
Cognitive Disorder 3 96.24 Very High Very High Very High
Sleep Disorders 2 95.40 Very High Very High Very High
Deafness 2 91.00 High High
Attention Deficit Hyperactivity Disorder 2 88.56 High High
Manic Depressive Disorder 2 87.96 High High
Pain 4 87.12 High High
Ganglion Cysts 18 56.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patch-clamp electrophysiology on cell lines expressing Kv7 channel subtypes, Maxipost (BMS-204352) exerted positive modulation of all neuronal Kv7 channels, whereas its R-enantiomer was a negative modulator.
Regulation (modulation) of Kv7 in neuronal
1) Confidence 0.07 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15814569 Disease Relevance 0.57 Pain Relevance 0.26
In conclusion, these in vitro and in vivo studies provide compelling evidence that neuronal Kv7 channels are a target for developing novel anxiolytics.
Regulation (target) of Kv7 in neuronal associated with anxiety disorder
2) Confidence 0.07 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15814569 Disease Relevance 0.77 Pain Relevance 0.06
Mutations in Kv7.2 and/or Kv7.3 genes are responsible for an autosomal-dominant epilepsy of the newborn defined as benign familial neonatal seizures (BFNS), whereas defects in the Kv7.4 gene have been found in families affected by a rare form of nonsyndromic autosomal-dominant hearing loss (DFNA2).
Regulation (responsible) of Kv7 associated with epilepsy, deafness and convulsion
3) Confidence 0.05 Published 2008 Journal Curr Opin Pharmacol Section Abstract Doc Link 18061539 Disease Relevance 0.34 Pain Relevance 0.17
Mutations in Kv7.2 and/or Kv7.3 genes are responsible for an autosomal-dominant epilepsy of the newborn defined as benign familial neonatal seizures (BFNS), whereas defects in the Kv7.4 gene have been found in families affected by a rare form of nonsyndromic autosomal-dominant hearing loss (DFNA2).
Regulation (responsible) of Kv7 associated with epilepsy, deafness and convulsion
4) Confidence 0.05 Published 2008 Journal Curr Opin Pharmacol Section Abstract Doc Link 18061539 Disease Relevance 0.34 Pain Relevance 0.17
Compound 15 also affected Kv7.2/3 gating by accelerating the activation kinetics (from t1/2?
Regulation (affected) of Kv7
5) Confidence 0.00 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2131780 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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