INT126116

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.16
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 4.67
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcna7) transmembrane transport (Kcna7)
Anatomy Link Frequency
neural 5
neuronal 4
neurons 2
ovary 2
SH-SY5Y 1
Kcna7 (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.7 3 99.36 Very High Very High Very High
potassium channel 16 98.44 Very High Very High Very High
cINOD 95 94.52 High High
diclofenac 140 94.20 High High
Neurotransmitter 7 93.68 High High
amygdala 1 92.08 High High
Pain 21 90.00 High High
hyperexcitability 26 89.08 High High
Neuronal excitability 15 79.92 Quite High
gABA 12 71.20 Quite High
Disease Link Frequency Relevance Heat
Lewis Lung Carcinoma 10 98.44 Very High Very High Very High
Colon Cancer 35 97.80 Very High Very High Very High
Anxiety Disorder 9 94.72 High High
Epilepsy 24 92.08 High High
Attention Deficit Hyperactivity Disorder 1 91.44 High High
Manic Depressive Disorder 1 90.84 High High
Pain 20 90.00 High High
Convulsion 56 87.28 High High
Deafness 5 76.24 Quite High
Neuroblastoma 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patch-clamp electrophysiology on cell lines expressing Kv7 channel subtypes, Maxipost (BMS-204352) exerted positive modulation of all neuronal Kv7 channels, whereas its R-enantiomer was a negative modulator.
Gene_expression (expressing) of Kv7 in neuronal
1) Confidence 0.16 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15814569 Disease Relevance 0.53 Pain Relevance 0.26
Although Kv7.1 is prevalently expressed in the cardiac muscle, Kv7.2, Kv7.3, Kv7.4, and Kv7.5 are expressed in neural tissue.
Gene_expression (expressed) of Kv7 in neural
2) Confidence 0.09 Published 2008 Journal Curr Opin Pharmacol Section Abstract Doc Link 18061539 Disease Relevance 0.24 Pain Relevance 0.13
Although Kv7.1 is prevalently expressed in the cardiac muscle, Kv7.2, Kv7.3, Kv7.4, and Kv7.5 are expressed in neural tissue.
Gene_expression (expressed) of Kv7 in neural
3) Confidence 0.09 Published 2008 Journal Curr Opin Pharmacol Section Abstract Doc Link 18061539 Disease Relevance 0.31 Pain Relevance 0.14
Although Kv7.1 is prevalently expressed in the cardiac muscle, Kv7.2, Kv7.3, Kv7.4, and Kv7.5 are expressed in neural tissue.
Gene_expression (expressed) of Kv7 in neural
4) Confidence 0.09 Published 2008 Journal Curr Opin Pharmacol Section Abstract Doc Link 18061539 Disease Relevance 0.31 Pain Relevance 0.14
Although Kv7.1 is prevalently expressed in the cardiac muscle, Kv7.2, Kv7.3, Kv7.4, and Kv7.5 are expressed in neural tissue.
Gene_expression (expressed) of Kv7 in neural
5) Confidence 0.09 Published 2008 Journal Curr Opin Pharmacol Section Abstract Doc Link 18061539 Disease Relevance 0.31 Pain Relevance 0.14
Although Kv7.1 is prevalently expressed in the cardiac muscle, Kv7.2, Kv7.3, Kv7.4, and Kv7.5 are expressed in neural tissue.
Gene_expression (expressed) of Kv7 in neural
6) Confidence 0.09 Published 2008 Journal Curr Opin Pharmacol Section Abstract Doc Link 18061539 Disease Relevance 0.31 Pain Relevance 0.14
Five members of the family have been identified to date, including the cardiac channel Kv7.1 (formerly known as KvLQT1) and four neuronal Kv7.x channels, Kv7.2-5.
Gene_expression (channels) of Kv7 in neuronal
7) Confidence 0.03 Published 2009 Journal Curr. Pharm. Des. Section Abstract Doc Link 19442190 Disease Relevance 0.20 Pain Relevance 0.17
Five members of the family have been identified to date, including the cardiac channel Kv7.1 (formerly known as KvLQT1) and four neuronal Kv7.x channels, Kv7.2-5.
Gene_expression (channels) of Kv7 in neuronal
8) Confidence 0.03 Published 2009 Journal Curr. Pharm. Des. Section Abstract Doc Link 19442190 Disease Relevance 0.20 Pain Relevance 0.17
Five members of the family have been identified to date, including the cardiac channel Kv7.1 (formerly known as KvLQT1) and four neuronal Kv7.x channels, Kv7.2-5.
Gene_expression (channels) of Kv7 in neuronal
9) Confidence 0.03 Published 2009 Journal Curr. Pharm. Des. Section Abstract Doc Link 19442190 Disease Relevance 0.20 Pain Relevance 0.17
In a first screen, two parameters were checked: (a) the non-selective inhibition of COX-1/COX-2 enzyme activities, measured by the production of PGE2 in cultured mouse colon adenocarcinoma (CT26) and mouse Lewis lung carcinoma cells (D122) cells; (b) the M-channel activity, measured by the heterologous coexpression of Kv7.2 and Kv7.3 subunits in Chinese hamster ovary (CHO) cells.
Gene_expression (coexpression) of Kv7 in ovary associated with colon cancer and lewis lung carcinoma
10) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2131780 Disease Relevance 0.37 Pain Relevance 0.29
Recombinant expression of Kv7.2/3 channels in CHO cells
Gene_expression (expression) of Kv7
11) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2131780 Disease Relevance 0.38 Pain Relevance 0.28
We characterized further its action on recombinant Kv7.2/3 channels expressed in CHO cells and its properties on primary cultured neurons.
Gene_expression (expressed) of Kv7 in neurons
12) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2131780 Disease Relevance 0.33 Pain Relevance 0.05
In a first screen, two parameters were checked: (a) the non-selective inhibition of COX-1/COX-2 enzyme activities, measured by the production of PGE2 in cultured mouse colon adenocarcinoma (CT26) and mouse Lewis lung carcinoma cells (D122) cells; (b) the M-channel activity, measured by the heterologous coexpression of Kv7.2 and Kv7.3 subunits in Chinese hamster ovary (CHO) cells.
Gene_expression (coexpression) of Kv7 in ovary associated with colon cancer and lewis lung carcinoma
13) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2131780 Disease Relevance 0.37 Pain Relevance 0.29
When tested on recombinant Kv7.2/3 channels that were heterologously expressed in CHO cells, compound 13 potently and dose-dependently produced a blockade of the K+ currents (IC50?
Gene_expression (expressed) of Kv7
14) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2131780 Disease Relevance 0.26 Pain Relevance 0.29
These encode Kv7 channel subunits, which are expressed widely in the brain, exhibit voltage dependent activation, are functionally active at the resting membrane potential of many neurons and can be modulated by neurotransmitters (Hansen et al., 2008).
Gene_expression (expressed) of Kv7 in neurons associated with neurotransmitter
15) Confidence 0.01 Published 2009 Journal Neuroscience Section Body Doc Link PMC2661429 Disease Relevance 0.11 Pain Relevance 0.21
Furthermore, RT-PCR analysis of 22 transcripts of voltage-gated ion channels in SH-SY5Y cells showed the expressions of Cav1.3, Kir2.1, Kv1.4, Kv2.1, Kv4.2, Kv7.1, BK(Ca), and Nav1.7, and those of BK(Ca) and Nav1.7 were higher in CD133(+) than in CD133(-) cells.
Gene_expression (expressions) of Kv7 in SH-SY5Y associated with nav1.7
16) Confidence 0.00 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20438714 Disease Relevance 0.28 Pain Relevance 0.26

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox