INT126119

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 1.31
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TCN1)
Anatomy Link Frequency
T-cell 2
lymphocytes 1
dermis 1
TCN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 15 99.52 Very High Very High Very High
cytokine 45 91.84 High High
Inflammation 37 84.00 Quite High
agonist 12 61.08 Quite High
transdermal 10 56.56 Quite High
Pain 12 50.00 Quite Low
gABA 4 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
pruritus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 52 99.04 Very High Very High Very High
Pain 10 92.08 High High
Skin Cancer 71 88.24 High High
INFLAMMATION 37 84.00 Quite High
Anaerobic Bacterial Infections 15 82.56 Quite High
Eosinophilia 20 71.88 Quite High
Obesity 1 66.76 Quite High
Cancer 14 60.80 Quite High
Hypersensitivity 31 60.12 Quite High
Sleep Disorders 8 55.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the observed layer effect among compartments, the superficial papillary dermis may have less of a Th2 effect, suggestive of the possibility that this compartment may be a more receptive environment for inducing a Th1/Tc1 response.
Positive_regulation (inducing) of Tc1 in dermis
1) Confidence 0.43 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.13 Pain Relevance 0.06
This finding likely has relevance for others using IFA adjuvants, as it reflects an unbalanced early Th2 dominance with the potential to compromise induction of Th1 and Tc1 responses.
Positive_regulation (induction) of Tc1
2) Confidence 0.43 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.23 Pain Relevance 0.03
Those systems will allow TCI of hypnotics and opioids concomitantly.
Positive_regulation (allow) of TCI
3) Confidence 0.40 Published 2008 Journal Rev Bras Anestesiol Section Body Doc Link 19378537 Disease Relevance 0 Pain Relevance 0
Propofol was administered by TCI, with successive targets of 0.6 and 1 microg x mL(-1), while the RS was evaluated: if = 3, LMA intubation was attempted, if < 3 the TCI was increased by steps of 0.2 microg x mL(-1) until an RS of 3 was reached.
Positive_regulation (increased) of TCI
4) Confidence 0.32 Published 2005 Journal Can J Anaesth Section Body Doc Link 15814760 Disease Relevance 0 Pain Relevance 0
This study aimed to evaluate the relationship between effect-site concentration of propofol and depth of anesthesia during the TCI induction in elderly patients.
Positive_regulation (induction) of TCI associated with anesthesia
5) Confidence 0.32 Published 2009 Journal Chin. Med. J. Section Abstract Doc Link 19493418 Disease Relevance 0 Pain Relevance 0.17
Despite the induction of CD4+ and CD8+ T-cell responses in most patients when peptide vaccines are administered in incomplete Freund's adjuvant [19,49,50], the immunization site microenvironment may not be optimized for induction of Th1/Tc1 responses.
Positive_regulation (induction) of Tc1 in T-cell associated with immunization
6) Confidence 0.29 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.19 Pain Relevance 0.06
Taking into account that the TCI target concentration during the 15-30 minute infusion interval was to be increased by 50% if stable anaesthesia was not observed in the 0-15 minute infusion interval, i.e. 7500 ng/mL, the maximum total amount infused in the first subject would be less than 6 mg/kg.
Positive_regulation (increased) of TCI
7) Confidence 0.24 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2914736 Disease Relevance 0.12 Pain Relevance 0
CONCLUSIONS: During the TCI induction, Ce of propofol with (1.9 +/- 0.3) microg/ml may make the elderly patients unconscious.
Positive_regulation (induction) of TCI
8) Confidence 0.21 Published 2009 Journal Chin. Med. J. Section Body Doc Link 19493418 Disease Relevance 0 Pain Relevance 0
Over a similar time frame, cells accumulated that may have negative effects on induction of Th1/Tc1 responses at the vaccination site.
Positive_regulation (induction) of Tc1
9) Confidence 0.13 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.26 Pain Relevance 0.04
We hypothesized that a vaccine in incomplete Freund's adjuvant (IFA) would increase dermal Th1 and Tc1-lymphocytes and mature DCs, but that repeated vaccination may increase regulatory cells.


Positive_regulation (increase) of Tc1 in lymphocytes
10) Confidence 0.11 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2936306 Disease Relevance 0.17 Pain Relevance 0
In the present study, both high levels of Th1 CD4 and Tc1 CD8 T cells (i.e. more than 0.1 % in the corresponding subset) have been detected in some individuals immunized with 10 or 30 ?
Positive_regulation (levels) of Tc1 in T cells
11) Confidence 0.09 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.06 Pain Relevance 0.12
TCI was conducted with Diprifusor for LCT and with BeComSim (custom-made software) for LCT/MCT.
Positive_regulation (conducted) of TCI
12) Confidence 0.06 Published 2006 Journal Acta Anaesthesiol Scand Section Body Doc Link 16643226 Disease Relevance 0.09 Pain Relevance 0
CONCLUSION: Our study showed that the frequency and severity of pain during TCI induction with propofol could be significantly reduced using LCT/MCT propofol rather than LCT propofol.


Positive_regulation (induction) of TCI
13) Confidence 0.06 Published 2006 Journal Acta Anaesthesiol Scand Section Body Doc Link 16643226 Disease Relevance 0.05 Pain Relevance 0

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