INT12616

Context Info Confidence 0.69 First Reported 1987 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 23 Total Number 23 Disease Relevance 6.57 Pain Relevance 5.81

extracellular region (REG1A)

Anatomy Link Frequency PSP 4 dendrites 1 neurons 1 pore 1 whiskers 1 REG1A (Homo sapiens)

Pain Link Frequency Relevance Heat tetrodotoxin 222 100.00 c fibre 5 100.00 Bile 11 99.80 anesthesia 36 99.62 Chronic pancreatitis 5 98.84 long-term potentiation 40 98.28 Action potential 24 97.88 antagonist 4 97.72 cINOD 3 97.52 opiate 6 97.12

Disease Link Frequency Relevance Heat Bordatella Infection 1 99.96 Cirrhosis 2 99.84 Stress 4 99.26 Choledocholithiasis 2 99.16 Pancreatitis 15 98.84 Injury 7 98.76 Targeted Disruption 2 98.56 Cancer 2 97.84 Choledochal Cyst 2 97.64 Depression 122 96.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The resultant mimicry of REM cellular events by carbachol extends to membrane potential depolarization, increased cellular excitability, enhancement of PSPs from reticular stimulation, and the absence of a burst discharge pattern.

Positive_regulation (enhancement) of PSPs

1) Confidence 0.69 Published 1989 Journal Brain Res. Section Abstract Doc Link 2914210 Disease Relevance 0 Pain Relevance 0.12

During hospital stay, PSP/reg levels were elevated significantly in patients with sepsis (146.4 ng/mL) and in patients with infections (111.4 ng/mL) compared with patients without infections (22.8 ng/mL).

Positive_regulation (elevated) of reg in PSP

2) Confidence 0.67 Published 2009 Journal Crit. Care Med. Section Body Doc Link 19325491 Disease Relevance 0.14 Pain Relevance 0

However, after stress (e.g., anesthesia), PSP/reg levels are increased transiently in animals without pancreatic injury.

Positive_regulation (increased) of reg in PSP associated with stress, anesthesia and injury

3) Confidence 0.67 Published 2009 Journal Crit. Care Med. Section Abstract Doc Link 19325491 Disease Relevance 0.37 Pain Relevance 0.10

In three neurons a progressive increase in the size and duration of the C-fiber PSPs occurred, resulting in an increase in the number of action potentials (windup), whereas in two, the repeated stimulation resulted in a progressive moderate depolarization of the neurons and an increase in the total number of action potentials evoked at both early and late latencies.

Positive_regulation (increase) of PSPs in neurons associated with action potential and c fibre

4) Confidence 0.51 Published 1987 Journal J. Neurophysiol. Section Abstract Doc Link 3655877 Disease Relevance 0 Pain Relevance 0.79

The gene expression observations are consistent with the results of previous studies: first, the documented changes in Reg1?

Positive_regulation (changes) of Reg

5) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.42 Pain Relevance 0.18

results in a compensatory increase in Reg1?

Positive_regulation (increase) of Reg

6) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.32 Pain Relevance 0.16

After 6 months the posterior tibial pressure (PTP) at the end of the treadmill exercise test also increased from 40 +/- 19 to 63 +/- 12 (p < 0.05).

Positive_regulation (increased) of PTP in posterior

7) Confidence 0.45 Published 1994 Journal Panminerva Med Section Abstract Doc Link 7831064 Disease Relevance 0.24 Pain Relevance 0.32

Furthermore, the serum PSP/reg-protein concentration was also significantly increased in liver cirrhosis, choledocholithiasis, and various cancers of the digestive system, and was extremely high in all patients tested with chronic renal failure.

Positive_regulation (increased) of reg in PSP associated with chronic renal failure, cirrhosis, cancer and choledocholithiasis

8) Confidence 0.45 Published 1995 Journal J. Gastroenterol. Section Abstract Doc Link 8574338 Disease Relevance 1.09 Pain Relevance 0.18

NSAIDs were recently reported to cause mitochondrial injury: to dissipate the mitochondrial transmembrane potential (MTP), and to induce mitochondrial permeability transition pore (PTP), which liberates cytochrome c.

Positive_regulation (induce) of PTP in pore associated with injury and cinod

9) Confidence 0.45 Published 2005 Journal Dig. Dis. Sci. Section Abstract Doc Link 16184425 Disease Relevance 0.59 Pain Relevance 0.27

Whereas only 7 of these patients showed a normal serum PSP/reg-protein concentration and a significantly increased elastase-I concentration, 15 of these patients showed a significantly increased serum PSP/reg-protein concentration and a normal serum elastase-I concentration.

Positive_regulation (increased) of reg in PSP

10) Confidence 0.45 Published 1995 Journal J. Gastroenterol. Section Abstract Doc Link 8574338 Disease Relevance 1.03 Pain Relevance 0.17

This implied that for a given excitatory synaptic conductance the distal dendrites generated larger PSPs than proximal dendrites.

Positive_regulation (generated) of PSPs in dendrites

11) Confidence 0.33 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2924322 Disease Relevance 0.08 Pain Relevance 0

Activated pancreatic enzyme and pancreatic stone protein (PSP/reg) in bile of patients with pancreaticobiliary maljunction/ choledochal cysts.

Positive_regulation (Activated) of reg in bile associated with bile and choledochal cyst

12) Confidence 0.21 Published 2004 Journal Dig. Dis. Sci. Section Title Doc Link 15628732 Disease Relevance 0.28 Pain Relevance 0.50

This maximum amplitude was similar to the one reached if the PSPs were activated during the up states.

Positive_regulation (activated) of PSPs

13) Confidence 0.20 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1925142 Disease Relevance 0.08 Pain Relevance 0.04

In the case that induced PSPs were followed by an up state, its initiation was generally not as steep as in barrel cortex and therefore the PSPs' peak occurred earlier than the local circuit recruitment.

Positive_regulation (induced) of PSPs in barrel cortex

14) Confidence 0.18 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1925142 Disease Relevance 0 Pain Relevance 0

The amplitude of PSPs evoked during the 200 ms following the occurrence of the up state was still increased to an average of the normalized values of ×1.9 times (2.3±0.7 mV) the amplitude of the PSPs occurring during downstates (Fig. 4D,E,F).

Positive_regulation (increased) of PSPs

15) Confidence 0.18 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1925142 Disease Relevance 0.08 Pain Relevance 0.04

We observed that intracortical PSPs evoked during the 200 ms following the occurrence of the up states (‘End’ period, see Results) were still greatly increased in amplitude in vivo to about 1.2 times the amplitude of the PSPs occurring during downstates (Fig. 4).

Positive_regulation (increased) of PSPs

16) Confidence 0.18 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1925142 Disease Relevance 0.17 Pain Relevance 0.03

The disparity between studies could be due to different reasons: 1) different amplitude of sensory evoked potentials (see Fig. 8C); 2) stimulating one whisker versus several whiskers, 3) averaging PSPs that trigger an up state together with those occurring during down states and comparing them with PSPs in up states, 4) different cortical areas, species, or specific synaptic connections that behave differently [40], [41].

Positive_regulation (averaging) of PSPs in whiskers

17) Confidence 0.13 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1925142 Disease Relevance 0 Pain Relevance 0.12

To explore which mechanisms could contribute to the increase in amplitude of PSPs during up states we first considered the effect of membrane voltage depolarization typical of up states.

Positive_regulation (increase) of PSPs

18) Confidence 0.13 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1925142 Disease Relevance 0 Pain Relevance 0

Preincubation of human trophoblastic cells with 0.1 microgram/ml Islet-Activating-Protein (IAP; also called pertussis toxin) did not modify basal adenylate cyclase activity but abolished the inhibition of adenylate cyclase activity by EKC, indicating that the effect of opiates on cAMP production was mediated by an IAP-sensitive GTP binding protein.

Positive_regulation (called) of Islet-Activating-Protein associated with bordatella infection and opiate

19) Confidence 0.09 Published 1991 Journal Life Sci. Section Abstract Doc Link 1650874 Disease Relevance 0.10 Pain Relevance 0.63

In hippocampal slices, the PSPs that are enhanced are monosynaptic [57].

Positive_regulation (enhanced) of PSPs

20) Confidence 0.09 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2832108 Disease Relevance 0.37 Pain Relevance 0.39

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