INT12617

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Context Info
Confidence 0.61
First Reported 1983
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 41
Total Number 45
Disease Relevance 7.38
Pain Relevance 15.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADCY1) small molecule metabolic process (ADCY1) plasma membrane (ADCY1)
nucleus (ADCY1) GTPase activity (ADCY1) transmembrane transport (ADCY1)
Anatomy Link Frequency
brains 5
SH-SY5Y 3
sensory neurons 1
pituitary 1
adipose tissue 1
ADCY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 5 100.00 Very High Very High Very High
Morphine 56 99.96 Very High Very High Very High
Opioid 65 99.82 Very High Very High Very High
opioid receptor 160 99.74 Very High Very High Very High
Neurotransmitter 6 99.66 Very High Very High Very High
Kinase C 32 99.52 Very High Very High Very High
addiction 58 99.40 Very High Very High Very High
agonist 385 99.32 Very High Very High Very High
Codeine 7 99.20 Very High Very High Very High
cocaine 41 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 21 100.00 Very High Very High Very High
Bacillus Anthracis Infection 44 99.08 Very High Very High Very High
Bordatella Infection 38 98.32 Very High Very High Very High
Urological Neuroanatomy 5 98.04 Very High Very High Very High
Obesity 33 97.80 Very High Very High Very High
Recurrence 4 96.80 Very High Very High Very High
Opiate Addiction 7 96.44 Very High Very High Very High
Drug Dependence 68 95.40 Very High Very High Very High
Syndrome 3 94.84 High High
Intellectual Impairment 1 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The extent of cyclic AMP (cAMP) mediated lipolysis in adipose tissue cells of man and several other animal species is regulated by the interplay of alpha- and beta-adrenoceptors modulating adenyl cyclase activity.
Regulation (modulating) of adenyl cyclase in adipose tissue associated with obesity
1) Confidence 0.61 Published 1984 Journal Int J Obes Section Abstract Doc Link 6152556 Disease Relevance 0.25 Pain Relevance 0.26
Herein, we have examined the quantitative changes of three adenylyl cyclase (AC) subtypes (I, II, and V/VI) in temporal cortex membranes from brains of heroin addicts and age-matched controls by immunoblotting.
Spec (examined) Regulation (changes) of adenylyl cyclase in brains
2) Confidence 0.61 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9622379 Disease Relevance 0 Pain Relevance 0.27
In this study we have examined, in detail, the muscarinic (M3) regulation of adenylyl cyclase in SH-SY5Y cells and report a role for both [Ca2+]e and [Ca2+]i.
Spec (examined) Regulation (regulation) of adenylyl cyclase in SH-SY5Y
3) Confidence 0.59 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7786304 Disease Relevance 0.07 Pain Relevance 0.13
Dopamine receptors are G-protein coupled receptors (GPCRs) which involve the regulation of adenylate cyclase (AC), generating the second messenger cyclic AMP (cAMP) from ATP.
Regulation (regulation) of AC associated with dopamine receptor
4) Confidence 0.44 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.24 Pain Relevance 0.37
Adenylyl cyclase in SH-SY5Y human neuroblastoma cells is regulated by intra- and extracellular calcium.
Regulation (regulated) of Adenylyl cyclase in SH-SY5Y associated with neuroblastoma
5) Confidence 0.43 Published 1995 Journal Biochem. Pharmacol. Section Title Doc Link 7786304 Disease Relevance 0.10 Pain Relevance 0.12
Taken collectively, these data suggest that SH-SY5Y cells express type 1, and possibly type 8 isoforms of adenylyl cyclase, which can be regulated by intra- and extracellular Ca2+.
Regulation (regulated) of adenylyl cyclase in SH-SY5Y
6) Confidence 0.43 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7786304 Disease Relevance 0.07 Pain Relevance 0.32
Submicromolar rises in [Ca2+]i produced via activation of phospholipase C (PLC) or Ca2+ channel opening, provide a mechanism by which Ca2+/calmodulin (CaM) or protein kinase C (PKC)-sensitive isoforms of adenylyl cyclase can be regulated.
Regulation (regulated) of adenylyl cyclase associated with kinase c
7) Confidence 0.43 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7786304 Disease Relevance 0.07 Pain Relevance 0.13
These results show that the endomorphins are capable of regulating adenylyl cyclase activity and that different adenylyl cyclase isozymes respond differently to these endogenous ligands.
Regulation (regulating) of cyclase
8) Confidence 0.39 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10698002 Disease Relevance 0.07 Pain Relevance 0.28
Regulation of adenylyl cyclase, ERK1/2, and CREB by Gz following acute and chronic activation of the delta-opioid receptor.
Regulation (Regulation) of adenylyl cyclase associated with opioid receptor
9) Confidence 0.38 Published 2000 Journal J. Neurochem. Section Title Doc Link 10737627 Disease Relevance 0.18 Pain Relevance 0.56
Regulation of adenylyl cyclase activity by all agonists is inhibited by pertussis toxin pretreatment or by coincubation with AM630 [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)-methanone], a CB2 antagonist.
Regulation (Regulation) of adenylyl cyclase associated with bordatella infection, antagonist and agonist
10) Confidence 0.36 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15901805 Disease Relevance 0.10 Pain Relevance 0.59
The phospholipase C specific inhibitor 1-[6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H -pyrrole-2,5-dione (U73122), which did not affect basal and forskolin-stimulated adenylyl cyclase activities, time- and dose-dependently blocked delta-opioid receptor-mediated inhibition of adenylyl cyclase activity, the EC50 (0.5 microM) of which was consistent with that for inhibition of bradykinin-dependent phospholipase C activation (EC50 = 1 microM).
Neg (not) Regulation (affect) of adenylyl cyclase associated with opioid receptor and bradykinin
11) Confidence 0.34 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543254 Disease Relevance 0.25 Pain Relevance 0.16
The signal transduction pathway to which the receptor is coupled is not dependent on receptor density, but its effect on adenylyl cyclase regulation is dependent on the current activity of adenylyl cyclase.
Regulation (effect) of cyclase
12) Confidence 0.32 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9371546 Disease Relevance 0.15 Pain Relevance 0.34
Chinese hamster ovary (CHO) cells stably transfected to express different densities of the human alpha2A-, alpha2B- and alpha2C-adrenoceptor subtypes, were used to characterize the regulation of adenylyl cyclase activity by alpha2-adrenoceptor agonists.
Regulation (regulation) of cyclase in CHO associated with agonist
13) Confidence 0.32 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9371546 Disease Relevance 0.14 Pain Relevance 0.09
The signal transduction pathway to which the receptor is coupled is not dependent on receptor density, but its effect on adenylyl cyclase regulation is dependent on the current activity of adenylyl cyclase.
Regulation (effect) of cyclase
14) Confidence 0.32 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9371546 Disease Relevance 0.15 Pain Relevance 0.36
Thus, these data show that phosphorylation of MOR1TAG is not an obligatory event for the DAMGO-induced loss in the adenylyl cyclase regulation by the receptor.
Regulation (regulation) of adenylyl cyclase
15) Confidence 0.30 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10092593 Disease Relevance 0 Pain Relevance 0.38
Acute and chronic activation of the mu-opioid receptor with the endogenous ligand endomorphin differentially regulates adenylyl cyclase isozymes.
Regulation (regulates) of cyclase associated with narcan and opioid receptor
16) Confidence 0.28 Published 2000 Journal Neuropharmacology Section Title Doc Link 10698002 Disease Relevance 0.09 Pain Relevance 0.39
Differential alteration of adenylyl cyclase subtypes I, II, and V/VI in postmortem human brains of heroin addicts.
Regulation (alteration) of adenylyl cyclase in brains
17) Confidence 0.27 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Title Doc Link 9622379 Disease Relevance 0 Pain Relevance 0.26
Moreover, in membranes of different brain regions, NDMC stimulated [(35)S]GTPgammaS binding and regulated adenylyl cyclase activity and the effects were potently antagonized by naltrindole.
Regulation (regulated) of adenylyl cyclase in brain
18) Confidence 0.26 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16841075 Disease Relevance 0 Pain Relevance 0.59
In the absence of beta-adrenergic stimulation, i.e. under basal conditions, ACh depresses ICa if the adenylate cyclase is under a tonic activation [20,21].
Regulation (under) of adenylate cyclase
19) Confidence 0.26 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2894799 Disease Relevance 0 Pain Relevance 0.11
Alpha2-adrenoceptor regulation of adenylyl cyclase in CHO cells: dependence on receptor density, receptor subtype and current activity of adenylyl cyclase.
Regulation (regulation) of cyclase associated with addiction
20) Confidence 0.24 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9371546 Disease Relevance 0.14 Pain Relevance 0.09

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