INT126177

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 14.34
Pain Relevance 5.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Atf3) nucleus (Atf3) DNA binding (Atf3)
Anatomy Link Frequency
sensory neurons 3
neurons 3
dorsal root ganglia 1
Atf3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 53 99.70 Very High Very High Very High
Neuropathic pain 21 98.28 Very High Very High Very High
antagonist 24 97.28 Very High Very High Very High
Inflammation 68 97.12 Very High Very High Very High
Mono iodoacetate 57 96.40 Very High Very High Very High
dorsal root ganglion 90 96.24 Very High Very High Very High
Peripheral nerve injury 5 95.08 Very High Very High Very High
agonist 66 94.08 High High
Spinal cord 27 93.32 High High
IPN 2 93.00 High High
Disease Link Frequency Relevance Heat
Pain 59 99.70 Very High Very High Very High
Neuropathic Pain 49 99.40 Very High Very High Very High
Colon Cancer 26 99.28 Very High Very High Very High
Breast Cancer 331 98.88 Very High Very High Very High
Injury 37 98.88 Very High Very High Very High
Cancer 591 98.68 Very High Very High Very High
INFLAMMATION 101 97.12 Very High Very High Very High
Ganglion Cysts 92 96.24 Very High Very High Very High
Targeted Disruption 11 95.60 Very High Very High Very High
Nervous System Injury 13 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This tumor-induced injury of sensory nerve fibers is accompanied by an increase in ongoing and movement-evoked pain behaviors, an upregulation of activating transcription factor 3 (ATF3) and galanin by sensory neurons that innervate the tumor-bearing femur, upregulation of glial fibrillary acidic protein (GFAP) and hypertrophy of satellite cells surrounding sensory neuron cell bodies within the ipsilateral dorsal root ganglia (DRG), and macrophage infiltration of the DRG ipsilateral to the tumor-bearing femur.
Positive_regulation (upregulation) of ATF3 in sensory neurons associated with pain, hypertrophy, cancer and injury
1) Confidence 0.70 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15817267 Disease Relevance 1.60 Pain Relevance 0.71
This tumor-induced injury of sensory nerve fibers is accompanied by an increase in ongoing and movement-evoked pain behaviors, an upregulation of activating transcription factor 3 (ATF3) and galanin by sensory neurons that innervate the tumor-bearing femur, upregulation of glial fibrillary acidic protein (GFAP) and hypertrophy of satellite cells surrounding sensory neuron cell bodies within the ipsilateral dorsal root ganglia (DRG), and macrophage infiltration of the DRG ipsilateral to the tumor-bearing femur.
Positive_regulation (upregulation) of activating transcription factor 3 in sensory neurons associated with pain, hypertrophy, cancer and injury
2) Confidence 0.70 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15817267 Disease Relevance 1.60 Pain Relevance 0.71
Accordingly, a higher number of injured DRG neurons was identified by activating transcription factor 3 (ATF3) staining in 5-HTT-/- mice after CFA.
Positive_regulation (activating) of ATF3 in neurons
3) Confidence 0.60 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18187350 Disease Relevance 1.30 Pain Relevance 0.98
In MDA-MB231 cells, ATF-3 and NAG-1 are upregulated through a PPAR-?
Positive_regulation (upregulated) of ATF-3
4) Confidence 0.35 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 1.05 Pain Relevance 0.19
In BT549 cells, the increase in ATF3 after CDIM9 treatment leads to the observed growth inhibition in vitro.
Positive_regulation (increase) of ATF3
5) Confidence 0.35 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.98 Pain Relevance 0.18
The induction of NAG-1 and ATF3 were not inhibited by the PPAR-?
Positive_regulation (induction) of ATF3
6) Confidence 0.35 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.56 Pain Relevance 0.17
Furthermore, ATF-3 is upregulated in HCT-116 human colorectal cancer cells following treatment with PPAR-?
Positive_regulation (upregulated) of ATF-3 associated with colon cancer
7) Confidence 0.35 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 1.13 Pain Relevance 0.19
ATF3 was also elevated in both MDA-MB231 and BT549 cells treated with CDIM9 (Figure 3b).
Positive_regulation (elevated) of ATF3
8) Confidence 0.35 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.56 Pain Relevance 0.17
ATF-3 (activating transcription factor 3) is transcriptional repressor involved in survival and regeneration of sensory neurons [93,94] that responds to insulin [95].
Positive_regulation (activating) of ATF-3 in sensory neurons
9) Confidence 0.33 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.63 Pain Relevance 0.18
Our observation of ATF-3 and NAG-1 induction by CDIM9 may also contribute to tumor growth inhibition.
Positive_regulation (induction) of ATF-3 associated with cancer
10) Confidence 0.25 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.97 Pain Relevance 0.06
Using this strategy, it was found that at day 1 post-infusion there was a marked up-regulation of activated transcription factor-3 (ATF3), wich is a marker of cell injury/regeneration [48,49] in a subpopulation of large and small DRG neurons.
Positive_regulation (regulation) of ATF3 in neurons associated with dorsal root ganglion and injury
11) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2289805 Disease Relevance 1.34 Pain Relevance 0.39
Using this strategy, it was found that at day 1 post-infusion there was a marked up-regulation of activated transcription factor-3 (ATF3), wich is a marker of cell injury/regeneration [48,49] in a subpopulation of large and small DRG neurons.
Positive_regulation (activated) of ATF3 in neurons associated with dorsal root ganglion and injury
12) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2289805 Disease Relevance 1.28 Pain Relevance 0.39
Furthermore, in one study, a significant increase in the levels of ATF-3 (a marker for neuropathy) in L5 dorsal root ganglia was found at days 8 and 14 following MIA injection in rats, however, no differences were found at later time points up to days 35 [16].
Positive_regulation (increase) of ATF-3 in dorsal root ganglia associated with mono iodoacetate and neuropathic pain
13) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2678995 Disease Relevance 0.98 Pain Relevance 1.21
factor 3 (ATF3) was induced after X-irradiation [5].
Positive_regulation (induced) of ATF3
14) Confidence 0.21 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0.35 Pain Relevance 0.04

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