INT12618

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Context Info
Confidence 0.68
First Reported 1990
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 54
Total Number 55
Disease Relevance 32.03
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IAPP) extracellular region (IAPP) cell-cell signaling (IAPP)
Anatomy Link Frequency
bladder 3
thoracic 2
body 2
respiratory 2
visceral 1
IAPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 15 99.48 Very High Very High Very High
Nucleus accumbens 6 99.28 Very High Very High Very High
nociceptor 6 98.48 Very High Very High Very High
opiate 6 96.08 Very High Very High Very High
narcan 2 94.76 High High
antagonist 1 94.40 High High
lidocaine 2 92.64 High High
Pain 17 88.44 High High
methotrexate 2 87.12 High High
anesthesia 65 81.04 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 273 100.00 Very High Very High Very High
Pressure And Volume Under Development 115 100.00 Very High Very High Very High
Bordatella Infection 1 99.96 Very High Very High Very High
Renal Failure 93 99.92 Very High Very High Very High
Diabetes Mellitus 297 99.88 Very High Very High Very High
Injury 120 99.84 Very High Very High Very High
Critical Illness 96 99.84 Very High Very High Very High
Disorders Of Creatine Metabolism 77 99.84 Very High Very High Very High
Pneumoperitoneum 36 99.76 Very High Very High Very High
Compartment Syndromes 356 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Iberti and colleagues [10], in a canine model of increased IAP, estimated bladder pressure with the bladder empty; they demonstrated that the IBP accurately reflected the IAP.
Positive_regulation (increased) of IAP in bladder
1) Confidence 0.68 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 0.35 Pain Relevance 0
An increase in IAP is associated with various organ dysfunctions (local and systemic), which in turn are associated with significantly increased in morbidity and mortality [1].
Positive_regulation (increase) of IAP
2) Confidence 0.68 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 0.11 Pain Relevance 0
Rapid infusion of saline at a temperature lower than body temperature may activate contraction of the detrusor muscle (as mentioned above) by a reflex loop through nociceptors with C afferent fibres located in the bladder wall [26], causing a falsely elevated IAP recording.
Positive_regulation (elevated) of IAP in nociceptors associated with nociceptor and overactive bladder
3) Confidence 0.68 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 0.47 Pain Relevance 0.10
In humans with increased IAP, intravascular pressure in the inferior vena cava was not reflected by a similar increase in the superior caval vein pressure, due to a "waterfall" effect [44,45].
Positive_regulation (increased) of IAP in superior
4) Confidence 0.67 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912801 Disease Relevance 0.08 Pain Relevance 0
Insertion of the pins led to a significant increase in HR, SAP, MAP and DAP in the control group.
Positive_regulation (increase) of DAP
5) Confidence 0.67 Published 1999 Journal Anaesthesiol Reanim Section Abstract Doc Link 10372436 Disease Relevance 0.06 Pain Relevance 0.36
Serum ACP, ALP and IAP were elevated at the initial diagnosis pathologically.
Positive_regulation (elevated) of IAP
6) Confidence 0.67 Published 1990 Journal Hinyokika Kiyo Section Abstract Doc Link 1696064 Disease Relevance 0.52 Pain Relevance 0.13
Because of increasing severity of organ dysfunction in spite of maximal supportive care and elevated IAP, a diagnosis of ACS was made and a decompressive laparostomy was performed 38 hours post-admission.
Positive_regulation (increasing) of IAP associated with compartment syndromes
7) Confidence 0.63 Published 2008 Journal World J Emerg Surg Section Body Doc Link PMC2266717 Disease Relevance 0.29 Pain Relevance 0.05
Increased IAP reduces venous return and increases intra-thoracic pressure, with impairment of ventricular compliance.
Positive_regulation (Increased) of IAP in thoracic
8) Confidence 0.59 Published 1999 Journal Crit Care Section Body Doc Link PMC29028 Disease Relevance 0.82 Pain Relevance 0
The increase in IAP evoked a transition of the abdominal venous compartment from a zone 3 to a zone 2 condition, presumably impairing venous return despite an increased pressure gradient between the abdominal and thoracic compartments [44].
Positive_regulation (increase) of IAP in thoracic
9) Confidence 0.59 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912801 Disease Relevance 0.07 Pain Relevance 0.06
Accordingly, PEEP and increased IAP seems to be the most crucial of the studied circumstances for venous return [46].
Positive_regulation (increased) of IAP
10) Confidence 0.59 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912801 Disease Relevance 0.06 Pain Relevance 0.09
Interestingly, both the increase in IAP and application of PEEP resulted in an increase in intravascular pressure in the inferior vena cava.
Positive_regulation (increase) of IAP in inferior vena cava
11) Confidence 0.59 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912801 Disease Relevance 0.10 Pain Relevance 0
It is possible that higher PEEP levels in our study would have increased IAP.
Positive_regulation (increased) of IAP
12) Confidence 0.59 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912801 Disease Relevance 0.42 Pain Relevance 0
Because many of the effects of ACS are clinically indistinguishable from those of other common entities related to critically ill patients, it is probable that the influence of an elevated IAP is not infrequently missed in a patient with multifactorial complications.
Positive_regulation (elevated) of IAP associated with compartment syndromes and critical illness
13) Confidence 0.51 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2992055 Disease Relevance 0.43 Pain Relevance 0
The World Society of Abdominal Compartment Syndrome has defined Intra-abdominal hypertension as a sustained or repeated pathologic elevation of IAP ?
Positive_regulation (elevation) of IAP associated with compartment syndromes and hypertension
14) Confidence 0.51 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2992055 Disease Relevance 1.27 Pain Relevance 0.12
This suggests that the bladder should be filled only minimally if an accurate measurement of IAP is to be obtained, especially in patients with prolonged catheterization.
Positive_regulation (measurement) of IAP in bladder
15) Confidence 0.49 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 0.49 Pain Relevance 0.08
Intra-abdominal hypertension (IAH), defined as an abnormal increase in IAP, can be common in critically ill patients, being present in 18% to 81% of the patients depending on the cut-off level used [2-8].
Positive_regulation (increase) of IAP associated with critical illness and hypertension
16) Confidence 0.46 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 0.82 Pain Relevance 0
ACS is a poorly appreciated complication of increased IAP.
Positive_regulation (increased) of IAP associated with compartment syndromes
17) Confidence 0.45 Published 1999 Journal Crit Care Section Body Doc Link PMC29028 Disease Relevance 0.60 Pain Relevance 0
Prolonged, unrelieved elevation of IAP can produce pulmonary compromise, renal impairment, cardiac failure, central nervous dysfunction, shock, and death [1,2,3,4,5,6].
Positive_regulation (elevation) of IAP associated with shock, death and myocardial infarction
18) Confidence 0.45 Published 1999 Journal Crit Care Section Body Doc Link PMC29028 Disease Relevance 0.74 Pain Relevance 0
We hypothesized that increased IAP decreases during PEEP release, and that this effect is more pronounced in the upper abdomen and intra-vascularly.


Positive_regulation (increased) of IAP in abdomen
19) Confidence 0.45 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912801 Disease Relevance 0.07 Pain Relevance 0.13
Increases in IAP are also associated with increased respiratory pressures, and decreased lung compliance and gas exchange [41,42].
Positive_regulation (Increases) of IAP in respiratory
20) Confidence 0.45 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912801 Disease Relevance 0.26 Pain Relevance 0

General Comments

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