INT126197

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Context Info
Confidence 0.72
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 7.34
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
astrocytes 1
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 270 99.50 Very High Very High Very High
Inflammatory marker 3 99.02 Very High Very High Very High
cINOD 190 98.58 Very High Very High Very High
agonist 42 97.54 Very High Very High Very High
Hippocampus 64 97.40 Very High Very High Very High
glial activation 10 97.20 Very High Very High Very High
Inflammatory response 30 94.96 High High
COX2 8 94.04 High High
cytokine 60 92.36 High High
ischemia 28 79.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 329 99.50 Very High Very High Very High
Targeted Disruption 248 99.44 Very High Very High Very High
Aging 30 98.94 Very High Very High Very High
Amyloid Plaque 89 95.96 Very High Very High Very High
Hypoxia 76 95.76 Very High Very High Very High
Stress 213 93.20 High High
Disease 1033 89.76 High High
Obesity 11 87.92 High High
Alzheimer's Dementia 166 85.80 High High
Brain Hemorrhage 1 79.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
production possibly via increases in transcription of the BACE1 gene through this binding site [50].
Transcription (transcription) of BACE1 gene
1) Confidence 0.72 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.51 Pain Relevance 0.04
Thus, in addition to a number of transcriptional factors acting as either activators or repressors of BACE1 transcription, alternative splicing events, intracellular signal transduction pathways, post-translational modifications and alterations in protein half-life can affect the level and enzymatic activity of BACE1.
Transcription (transcription) of BACE1
2) Confidence 0.71 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.44 Pain Relevance 0
It is likely that these sites influence transcriptional activity from the BACE1 promoter.
Transcription (activity) of BACE1
3) Confidence 0.68 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.71 Pain Relevance 0
Given that Tg2576 mice overexpress human APP with the Swedish mutation, Zohar and colleagues speculated that it was this APP overexpression in Tg2576 mice that effected the differential expression of BACE1 splice variants in these animals and suggested that APP may exert a regulatory role on BACE1 transcripts.
Transcription (transcripts) of BACE1
4) Confidence 0.68 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.31 Pain Relevance 0
However, during aging, wild-type mice undergo an increase in the relative abundance of the BACE1-I-501 variant.
Transcription (abundance) of BACE1-I-501 associated with aging
5) Confidence 0.68 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.34 Pain Relevance 0
Together, biochemical analyses demonstrated that BACE1+/?
Spec (analyses) Transcription (demonstrated) of BACE1
6) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0 Pain Relevance 0
While it is apparent that BACE1 expression can be tightly regulated at the transcriptional level, in some studies BACE1 mRNA levels in either neurons or astrocytes around amyloid plaques in APP transgenic brain are not elevated [97,100,101], implying that a post-translational mechanism may be responsible for the BACE1 increase.
Transcription (at) of BACE1 in astrocytes associated with targeted disruption and amyloid plaque
7) Confidence 0.53 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.32 Pain Relevance 0.19
In parallel to the suppression of inflammatory markers, pioglitazone and ibuprofen treatment decreased beta-secretase-1 (BACE1) mRNA and protein levels.
Transcription (levels) of beta-secretase-1 associated with inflammatory marker
8) Confidence 0.51 Published 2005 Journal Brain Section Abstract Doc Link 15817521 Disease Relevance 0.76 Pain Relevance 0.83
In parallel to the suppression of inflammatory markers, pioglitazone and ibuprofen treatment decreased beta-secretase-1 (BACE1) mRNA and protein levels.
Transcription (levels) of BACE1 associated with inflammatory marker
9) Confidence 0.51 Published 2005 Journal Brain Section Abstract Doc Link 15817521 Disease Relevance 0.76 Pain Relevance 0.82
levels under inflammatory conditions by affecting BACE1 transcription (Sastre et al., 2006b, 2008).
Transcription (transcription) of BACE1 associated with inflammation
10) Confidence 0.49 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2893374 Disease Relevance 0.62 Pain Relevance 0.62
activation by agonists such as thiazolidinediones (TZD) and certain NSAIDs such as ibuprofen, indomethacin and naproxen results in a decrease of BACE1 transcription, expression and activity [70].
Transcription (transcription) of BACE1 associated with cinod and agonist
11) Confidence 0.46 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.74 Pain Relevance 0.44
under inflammatory conditions, which would result in an increase in BACE1 transcription and A?
Transcription (transcription) of BACE1 associated with inflammation
12) Confidence 0.40 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.67 Pain Relevance 0.45
BACE1 transcription and expression.
Transcription (transcription) of BACE1
13) Confidence 0.24 Published 2008 Journal PPAR Research Section Body Doc Link PMC2465016 Disease Relevance 0.38 Pain Relevance 0.17
These mice also showed significant reduction in COX-2 and iNOS mRNA, BACE-1 mRNA and protein levels, and reduction in area occupied and staining intensity of A?
Transcription (mRNA) of BACE-1 mRNA
14) Confidence 0.07 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644496 Disease Relevance 0.78 Pain Relevance 0.30

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