INT126198

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.95
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory marker 1 99.22 Very High Very High Very High
cINOD 53 98.82 Very High Very High Very High
agonist 6 97.78 Very High Very High Very High
COX2 3 94.44 High High
Inflammation 60 91.40 High High
Hippocampus 8 90.28 High High
cytokine 14 72.64 Quite High
Inflammatory response 6 71.04 Quite High
imagery 2 39.08 Quite Low
positron emission tomography 1 38.76 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 75 99.06 Very High Very High Very High
Amyloid Plaque 24 90.88 High High
Disease 208 84.08 Quite High
Alzheimer's Dementia 30 78.40 Quite High
Targeted Disruption 49 75.00 Quite High
Stress 29 70.72 Quite High
Death 10 70.44 Quite High
Hypoxia 15 56.20 Quite High
Cardiovascular Disease 4 52.08 Quite High
Obesity 1 43.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, in addition to a number of transcriptional factors acting as either activators or repressors of BACE1 transcription, alternative splicing events, intracellular signal transduction pathways, post-translational modifications and alterations in protein half-life can affect the level and enzymatic activity of BACE1.
Negative_regulation (repressors) of Transcription (transcription) of BACE1
1) Confidence 0.43 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.44 Pain Relevance 0
In parallel to the suppression of inflammatory markers, pioglitazone and ibuprofen treatment decreased beta-secretase-1 (BACE1) mRNA and protein levels.
Negative_regulation (decreased) of Transcription (levels) of BACE1 associated with inflammatory marker
2) Confidence 0.42 Published 2005 Journal Brain Section Abstract Doc Link 15817521 Disease Relevance 0.77 Pain Relevance 0.83
activation by agonists such as thiazolidinediones (TZD) and certain NSAIDs such as ibuprofen, indomethacin and naproxen results in a decrease of BACE1 transcription, expression and activity [70].
Negative_regulation (decrease) of Transcription (transcription) of BACE1 associated with cinod and agonist
3) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.74 Pain Relevance 0.44

General Comments

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