INT126198

Context Info Confidence 0.43 First Reported 2005 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.95 Pain Relevance 1.27

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1) endoplasmic reticulum (Bace1) enzyme binding (Bace1)

Bace1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory marker 1 99.22 cINOD 53 98.82 agonist 6 97.78 COX2 3 94.44 Inflammation 60 91.40 Hippocampus 8 90.28 cytokine 14 72.64 Inflammatory response 6 71.04 imagery 2 39.08 positron emission tomography 1 38.76

Disease Link Frequency Relevance Heat INFLAMMATION 75 99.06 Amyloid Plaque 24 90.88 Disease 208 84.08 Alzheimer's Dementia 30 78.40 Targeted Disruption 49 75.00 Stress 29 70.72 Death 10 70.44 Hypoxia 15 56.20 Cardiovascular Disease 4 52.08 Obesity 1 43.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, in addition to a number of transcriptional factors acting as either activators or repressors of BACE1 transcription, alternative splicing events, intracellular signal transduction pathways, post-translational modifications and alterations in protein half-life can affect the level and enzymatic activity of BACE1.

Negative_regulation (repressors) of Transcription (transcription) of BACE1

1) Confidence 0.43 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.44 Pain Relevance 0

In parallel to the suppression of inflammatory markers, pioglitazone and ibuprofen treatment decreased beta-secretase-1 (BACE1) mRNA and protein levels.

Negative_regulation (decreased) of Transcription (levels) of BACE1 associated with inflammatory marker

2) Confidence 0.42 Published 2005 Journal Brain Section Abstract Doc Link 15817521 Disease Relevance 0.77 Pain Relevance 0.83

activation by agonists such as thiazolidinediones (TZD) and certain NSAIDs such as ibuprofen, indomethacin and naproxen results in a decrease of BACE1 transcription, expression and activity [70].

Negative_regulation (decrease) of Transcription (transcription) of BACE1 associated with cinod and agonist

3) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.74 Pain Relevance 0.44

General Comments

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