INT12620

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Context Info
Confidence 0.44
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 2.98
Pain Relevance 10.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADCY1) small molecule metabolic process (ADCY1) plasma membrane (ADCY1)
nucleus (ADCY1) GTPase activity (ADCY1) transmembrane transport (ADCY1)
Anatomy Link Frequency
smooth muscle 2
brain 2
primary sensory neurons 2
ADCY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 131 100.00 Very High Very High Very High
opioid receptor 26 100.00 Very High Very High Very High
Opioid 15 100.00 Very High Very High Very High
Enkephalin 15 100.00 Very High Very High Very High
Morphine 13 100.00 Very High Very High Very High
narcan 6 99.64 Very High Very High Very High
mu opioid receptor 1 99.44 Very High Very High Very High
Analgesic 8 99.38 Very High Very High Very High
antagonist 30 99.22 Very High Very High Very High
lidocaine 8 98.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 9 100.00 Very High Very High Very High
Nociception 2 100.00 Very High Very High Very High
Neuroblastoma 15 95.00 High High
Glioma 4 94.36 High High
Ganglion Cysts 3 87.32 High High
Neuroma 1 85.96 High High
Injury 1 84.72 Quite High
Obesity 4 83.68 Quite High
Opiate Addiction 1 71.32 Quite High
INFLAMMATION 6 70.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, treatment with U73122 but not U73343 blocked the GTP-induced inhibition of adenylyl cyclase, indicating blockade at the level of Gi proteins.
Negative_regulation (blocked) of Negative_regulation (inhibition) of adenylyl cyclase
1) Confidence 0.44 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543254 Disease Relevance 0.19 Pain Relevance 0.15
These results suggest that lidocaine prevents muscarinic receptor-mediated signaling pathway and thereby reverses inhibition of adenylyl cyclase by methacholine in bovine tracheal smooth muscle.
Negative_regulation (reverses) of Negative_regulation (inhibition) of adenylyl cyclase in smooth muscle associated with lidocaine
2) Confidence 0.41 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12787832 Disease Relevance 0 Pain Relevance 0.61
The phospholipase C specific inhibitor 1-[6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H -pyrrole-2,5-dione (U73122), which did not affect basal and forskolin-stimulated adenylyl cyclase activities, time- and dose-dependently blocked delta-opioid receptor-mediated inhibition of adenylyl cyclase activity, the EC50 (0.5 microM) of which was consistent with that for inhibition of bradykinin-dependent phospholipase C activation (EC50 = 1 microM).
Negative_regulation (blocked) of Negative_regulation (inhibition) of adenylyl cyclase associated with opioid receptor and bradykinin
3) Confidence 0.32 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543254 Disease Relevance 0.25 Pain Relevance 0.17
Suppression of phospholipase C blocks Gi-mediated inhibition of adenylyl cyclase activity.
Negative_regulation (blocks) of Negative_regulation (inhibition) of adenylyl cyclase associated with analgesic
4) Confidence 0.32 Published 1998 Journal Eur. J. Pharmacol. Section Title Doc Link 9543254 Disease Relevance 0.26 Pain Relevance 0.35
Pretreatment of these cells with SNC-80 (100 nM) for 24 hr produced 1) a time-dependent reduction of delta receptor density, as measured by radioligand binding studies with [3H]naltrindole; 2) a shift in the EC50 value of SNC-80 from 7.7 +/- 4.2 nM to 44.1 +/- 12 nM, as measured by the cyclic AMP assay; 3) a reduction in the maximum inhibition of adenylyl cyclase activity from 86% to 48%; 4) a marked increase in the forskolin stimulation of basal cyclic AMP accumulation by nearly 100% (from 442 pmol/mg of protein to 824 pmol/mg of protein); and 5) a 5-fold increase in forskolin-stimulated cyclic AMP accumulation after addition of naltrindole.
Negative_regulation (reduction) of Negative_regulation (inhibition) of adenylyl cyclase
5) Confidence 0.23 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8819489 Disease Relevance 0 Pain Relevance 0.48
The rapid rate of receptor phosphorylation, occurring within minutes, did not correlate with the rate of the loss of agonist-mediated inhibition of adenylyl cyclase, which occurs in hours.
Negative_regulation (loss) of Negative_regulation (inhibition) of adenylyl cyclase associated with agonist
6) Confidence 0.21 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10092593 Disease Relevance 0.08 Pain Relevance 0.71
The absence of a direct correlation between the loss of [D-Ala2, MePhe4,Gly5-ol]Enkephalin inhibition of adenylyl cyclase activity and agonist-induced mu-opioid receptor phosphorylation.
Negative_regulation (loss) of Negative_regulation (inhibition) of adenylyl cyclase associated with agonist, opioid receptor and enkephalin
7) Confidence 0.21 Published 1999 Journal J. Biol. Chem. Section Title Doc Link 10092593 Disease Relevance 0.08 Pain Relevance 0.84
Preincubation of human trophoblastic cells with 0.1 microgram/ml Islet-Activating-Protein (IAP; also called pertussis toxin) did not modify basal adenylate cyclase activity but abolished the inhibition of adenylate cyclase activity by EKC, indicating that the effect of opiates on cAMP production was mediated by an IAP-sensitive GTP binding protein.
Negative_regulation (abolished) of Negative_regulation (inhibition) of cyclase associated with bordatella infection and opiate
8) Confidence 0.16 Published 1991 Journal Life Sci. Section Abstract Doc Link 1650874 Disease Relevance 0.10 Pain Relevance 0.62
Loss of both serine residues, but not either one alone, impaired the receptor-independent inhibition of adenylyl cyclase by the GTPase-deficient mutant.
Negative_regulation (impaired) of Negative_regulation (inhibition) of adenylyl cyclase
9) Confidence 0.14 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9166747 Disease Relevance 0.07 Pain Relevance 0.18
The receptor-mediated inhibition of adenylyl cyclase was abolished by pertussis toxin pretreatment and was blocked by a kappa-selective antagonist, norbinaltorphimine.
Negative_regulation (abolished) of Negative_regulation (inhibition) of cyclase associated with bordatella infection and antagonist
10) Confidence 0.07 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9109509 Disease Relevance 0.26 Pain Relevance 0.93
The receptor-mediated inhibition of adenylyl cyclase was abolished by pertussis toxin pretreatment and was blocked by a kappa-selective antagonist, norbinaltorphimine.
Negative_regulation (blocked) of Negative_regulation (inhibition) of cyclase associated with bordatella infection and antagonist
11) Confidence 0.07 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9109509 Disease Relevance 0.26 Pain Relevance 0.94
Other delta-antagonists, naltriben, naloxone, and ICI 174864, attenuated the inhibition of adenylyl cyclase activity mediated by TIPP.
Negative_regulation (attenuated) of Negative_regulation (inhibition) of cyclase associated with antagonist and narcan
12) Confidence 0.06 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11408548 Disease Relevance 0.22 Pain Relevance 0.66
Thus CB2 receptor agonists functionally inhibited nociceptive signalling in human primary sensory neurons via a mechanism shared with opioids, of adenylyl cyclase inhibition, but not via mu-opioid receptors.
Negative_regulation (inhibited) of Negative_regulation (inhibition) of cyclase in primary sensory neurons associated with nociception, mu opioid receptor, agonist and opioid
13) Confidence 0.04 Published 2008 Journal Pain Section Abstract Doc Link 18692962 Disease Relevance 0.75 Pain Relevance 1.42
Down-regulation of Gbeta and adenylate cyclase sensitization elicited by long-term morphine treatment were suppressed in the presence of carbobenzoxy-l-leucyl-l-leucyl-l-norvalinal (MG-115) or lactacystin.
Negative_regulation (suppressed) of Negative_regulation (Down-regulation) of cyclase associated with morphine
14) Confidence 0.04 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15901846 Disease Relevance 0.28 Pain Relevance 1.19
However, the association of PKCI with HmuOR reduced agonist-induced inhibition of adenylyl cyclase and suppressed HmuOR desensitization partially at the G protein level and completely at the adenylyl cyclase level.
Negative_regulation (reduced) of Negative_regulation (inhibition) of adenylyl cyclase associated with agonist
15) Confidence 0.02 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15496510 Disease Relevance 0 Pain Relevance 0.68
Chronic exposure of rats to R-PIA (6 days) also led to A1R desensitization in the brain, and subsequent reduced inhibition of adenylyl cyclase.
Negative_regulation (reduced) of Negative_regulation (inhibition) of adenylyl cyclase in brain
16) Confidence 0.01 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.19 Pain Relevance 0.16

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