INT12621

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Context Info
Confidence 0.08
First Reported 1991
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.07
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (LGALS1) cytoplasm (LGALS1) signal transducer activity (LGALS1)
extracellular space (LGALS1) signal transduction (LGALS1) extracellular region (LGALS1)
Anatomy Link Frequency
placenta 2
LGALS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 8 99.98 Very High Very High Very High
narcan 8 96.64 Very High Very High Very High
opiate 8 87.12 High High
adenocard 1 75.00 Quite High
antagonist 5 59.40 Quite High
agonist 6 43.52 Quite Low
Enkephalin 6 35.60 Quite Low
Analgesic 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Bordatella Infection 3 66.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This hypothesis was confirmed by 1) experiments on placental membranes showing that in absence of the cytoplasmic elements (membranes only), EKC had no effect on membrane adenylate cyclase and 2) experiments on placental cells showing that dibutyryl-cAMP (dbcAMP) stimulated hPL release.
Positive_regulation (stimulated) of Localization (release) of hPL
1) Confidence 0.08 Published 1991 Journal Life Sci. Section Abstract Doc Link 1650874 Disease Relevance 0.07 Pain Relevance 0.45
In order to understand the post-receptor events mediating hPL release by opioids in the human placenta, we studied the role of extracellular calcium.
Positive_regulation (mediating) of Localization (release) of hPL in placenta associated with opioid
2) Confidence 0.03 Published 1993 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7684340 Disease Relevance 0 Pain Relevance 0.42
We previously reported that kappa opioids stimulated the release of human placental lactogen (hPL) from trophoblastic cells and that this effect was prevented by co-incubation with naloxone.
Positive_regulation (stimulated) of Localization (release) of hPL associated with narcan and opioid
3) Confidence 0.02 Published 1993 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7684340 Disease Relevance 0 Pain Relevance 0.30

General Comments

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