INT126213

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.51
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TYRP1)
Anatomy Link Frequency
nociceptor 2
TYRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
TRP channel 1 100.00 Very High Very High Very High
Pain 3 99.16 Very High Very High Very High
nociceptor 2 98.12 Very High Very High Very High
Inflammation 2 96.48 Very High Very High Very High
Stimulus evoked pain 1 94.96 High High
analgesia 1 53.24 Quite High
Disease Link Frequency Relevance Heat
Pain 3 99.16 Very High Very High Very High
INFLAMMATION 2 96.48 Very High Very High Very High
Hypersensitivity 1 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Precise regulation of the expression, localization, and function of the TRP channels is crucial for their sensory role in nociceptor terminals, particularly after inflammation, when they contribute to pain hypersensitivity by undergoing changes in translation and trafficking as well as diverse posttranslational modifications.
Regulation (regulation) of Gene_expression (expression) of TRP in nociceptor associated with inflammation, trp channel, nociceptor, hypersensitivity and stimulus evoked pain
1) Confidence 0.44 Published 2005 Journal Neuron Section Abstract Doc Link 15820689 Disease Relevance 0.46 Pain Relevance 0.47
The quenching of Trp fluorescence was enhanced in the presence of charged micelles, compared to the buffer solution and the accessibility of the fluorophore to the quencher was dependent on the peptide and the alkylpyridinium: in ACTH(1-21) highest collisional constants were obtained using ethylpyridinium as quencher, indicating a location of the residue in the surface of the micelle, while in alpha-MSH the best quencher was hexylpyridinium, indicating insertion of the residue into the non-polar region of the micelles.
Regulation (quenching) of Gene_expression (fluorescence) of Trp
2) Confidence 0.44 Published 2009 Journal Biophys. Chem. Section Abstract Doc Link 19019530 Disease Relevance 0.05 Pain Relevance 0.08

General Comments

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