INT12622

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.55
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (LGALS1) cytoplasm (LGALS1) signal transducer activity (LGALS1)
extracellular space (LGALS1) signal transduction (LGALS1) extracellular region (LGALS1)
Anatomy Link Frequency
antibody secreting cells 1
syncytiotrophoblast 1
cytotrophoblast 1
placenta 1
LGALS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 8 99.84 Very High Very High Very High
opiate 20 99.68 Very High Very High Very High
narcan 12 96.64 Very High Very High Very High
antagonist 7 82.92 Quite High
adenocard 3 75.00 Quite High
agonist 6 43.52 Quite Low
Enkephalin 6 35.60 Quite Low
Analgesic 2 25.00 Low Low
cytokine 2 22.48 Low Low
fibrosis 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bordatella Infection 5 89.56 High High
Viral Infection 1 85.60 High High
Leukemia 2 76.48 Quite High
Thrombosis 16 60.32 Quite High
Disseminated Intravascular Coagulation 1 55.84 Quite High
Helminth Infection 1 48.12 Quite Low
Calcification 15 41.48 Quite Low
Myocardial Infarction 33 40.04 Quite Low
Fibrosis 20 5.00 Very Low Very Low Very Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although galectins can be secreted, they do so without a specific signal sequence.
Localization (secreted) of galectin
1) Confidence 0.78 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0 Pain Relevance 0
In order to prevent immunologic problems, many authors have proposed the inactivation of the primary complement factors, control of the expression of the complement activation regulator, the removal of anti-xenograft antibodies, multiple drugs that decrease the amount of anti-Gal antibody secreting cells, immunosuppressants, and so on (19, 20, 22-25).
Localization (antibody secreting cells) of Gal in antibody secreting cells
2) Confidence 0.73 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693593 Disease Relevance 0.26 Pain Relevance 0
We previously reported that kappa opiates stimulated the release of human placental lactogen (hPL) from human placental cells.
Localization (release) of hPL associated with opiate
3) Confidence 0.12 Published 1991 Journal Life Sci. Section Abstract Doc Link 1650874 Disease Relevance 0.06 Pain Relevance 0.41
This hypothesis was confirmed by 1) experiments on placental membranes showing that in absence of the cytoplasmic elements (membranes only), EKC had no effect on membrane adenylate cyclase and 2) experiments on placental cells showing that dibutyryl-cAMP (dbcAMP) stimulated hPL release.
Localization (release) of hPL
4) Confidence 0.11 Published 1991 Journal Life Sci. Section Abstract Doc Link 1650874 Disease Relevance 0.07 Pain Relevance 0.45
Also, IAP stimulated basal hPL release; the control levels were 22.4 ng/ml and 46.5 ng/ml without and with IAP respectively.
Localization (release) of hPL
5) Confidence 0.11 Published 1991 Journal Life Sci. Section Abstract Doc Link 1650874 Disease Relevance 0.09 Pain Relevance 0.60
In order to understand the post-receptor events mediating hPL release by opioids in the human placenta, we studied the role of extracellular calcium.
Localization (release) of hPL in placenta associated with opioid
6) Confidence 0.04 Published 1993 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7684340 Disease Relevance 0 Pain Relevance 0.42
We previously reported that kappa opioids stimulated the release of human placental lactogen (hPL) from trophoblastic cells and that this effect was prevented by co-incubation with naloxone.
Localization (release) of hPL associated with narcan and opioid
7) Confidence 0.03 Published 1993 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7684340 Disease Relevance 0 Pain Relevance 0.30
Within the placenta the syncytiotrophoblast also secretes human placental lactogen (hPL), which shares 67% sequence homology with prolactin and is able to signal through the prolactin receptor.
Localization (secretes) of hPL in syncytiotrophoblast
8) Confidence 0.02 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0 Pain Relevance 0
Thus at 4–5 weeks EGF stimulates cytotrophoblast cell proliferation, whereas at 6–12 weeks it stimulates secretion of human chorionic gonadotropin (hCG) and human placental lactogen (hPL) into the supernatant [19].
Localization (secretion) of hPL in cytotrophoblast
9) Confidence 0.02 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0.08 Pain Relevance 0

General Comments

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