INT126223

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 6.00
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
liver 1
synovial cells 1
muscle 1
band 1
small intestine 1
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 13 100.00 Very High Very High Very High
COX2 4 100.00 Very High Very High Very High
Snapping jaw 27 99.40 Very High Very High Very High
Inflammatory mediators 15 99.20 Very High Very High Very High
Paracetamol 120 98.12 Very High Very High Very High
Inflammatory response 18 97.00 Very High Very High Very High
Inflammation 271 95.44 Very High Very High Very High
ischemia 18 77.36 Quite High
pulpitis 2 76.64 Quite High
metalloproteinase 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Functional Bowel Disorder 4 99.76 Very High Very High Very High
Temporomandibular Joint Syndrome 27 99.40 Very High Very High Very High
Hypoxia 11 99.16 Very High Very High Very High
INFLAMMATION 304 98.80 Very High Very High Very High
Hyperglycemia 8 94.60 High High
Periodontitis 120 92.16 High High
Apoptosis 54 86.24 High High
Injury 31 85.36 High High
Death 13 85.04 High High
Middle Cerebral Artery Infarction 30 84.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, TMJ synovial cells were normally immunoreactive to iNOS, NF-?
iNOS Binding (immunoreactive) of in synovial cells associated with snapping jaw
1) Confidence 0.37 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998788 Disease Relevance 0.78 Pain Relevance 0.44
Indirect immunohistochemical labelling was performed to reveal binding of primary antibodies against endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS) and TGF-beta.
iNOS Binding (binding) of
2) Confidence 0.34 Published 2006 Journal Acta Histochem. Section Abstract Doc Link 16762404 Disease Relevance 0.26 Pain Relevance 0.07
In conclusion, the expression of iNOS in the small intestine following administration of NSAIDs results from COX-1 inhibition and is functionally associated with intestinal hypermotility and bacterial invasion.
iNOS Binding (associated) of in small intestine associated with functional bowel disorder and cinod
3) Confidence 0.32 Published 2006 Journal Dig. Dis. Sci. Section Abstract Doc Link 16944022 Disease Relevance 0.40 Pain Relevance 0.36
Rats were killed, serum prepared for determination of hepatocellular enzymes, and the liver assessed for iNOS and HO-1 by Western immunoblot.
iNOS Binding (assessed) of in liver
4) Confidence 0.32 Published 2005 Journal J Trauma Section Body Doc Link 15824646 Disease Relevance 0.09 Pain Relevance 0
binds to the iNOS promoter gene under hypoxic conditions.
iNOS Binding (binds) of associated with hypoxia
5) Confidence 0.31 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2975073 Disease Relevance 1.69 Pain Relevance 0.14
The application of LPS to the pulp increased NOS activity, PGE(2), and MMP-3 production associated with iNOS overactivity.
iNOS Binding (associated) of
6) Confidence 0.30 Published 2009 Journal J Endod Section Abstract Doc Link 19345799 Disease Relevance 0.29 Pain Relevance 0.31
Indirect immunohistochemical labelling was performed to reveal binding of primary antibodies against endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS) and TGF-beta.
inducible nitric oxide synthase Binding (binding) of
7) Confidence 0.30 Published 2006 Journal Acta Histochem. Section Abstract Doc Link 16762404 Disease Relevance 0.26 Pain Relevance 0.07
To verify the binding specificity for ICAM-1, P-selectin, iNOS and IL-1?
iNOS Binding (binding) of
8) Confidence 0.29 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0 Pain Relevance 0
To verify the binding specificity for ICAM-1, P-selectin, iNOS and IL-1?
iNOS Binding (specificity) of
9) Confidence 0.29 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0 Pain Relevance 0
The competition between arginase and iNOS for their common substrate, L-arginine, reduces NO production and favors polyamine synthesis, required for trypanosome development [7].
iNOS Binding (competition) of
10) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821905 Disease Relevance 0.07 Pain Relevance 0.04
In peritoneal macrophages, iNOS activity decreased from D10 (?
iNOS Binding (activity) of in peritoneal macrophages
11) Confidence 0.25 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2821905 Disease Relevance 0.25 Pain Relevance 0
At 8 days following ligation, positive staining for iNOS (Figure 6b) and nitrotyrosine (Figure 6d), was found in the gingivomucosal tissues from ligature-operated rats.
iNOS Binding (ligation) of
12) Confidence 0.25 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.29 Pain Relevance 0.04
Hypericum treatment abolished the staining for iNOS and nitrotyrosine (Figure 6c and 6e respectively).
iNOS Binding (staining) of
13) Confidence 0.25 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.28 Pain Relevance 0.03
Akt dysfunction is associated with increases in Akt S-nitrosylation and iNOS
iNOS Binding (associated) of
14) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.07 Pain Relevance 0.54
A previous study by our laboratory demonstrated that age-associated hyperglycemia and decreases in muscle glucose transporter-4 (Glut4) can be reversed by acetaminophen intervention [23], while other work using cultured cell has shown that acetaminophen can directly inhibit NO production and iNOS expression through its ability to diminish NF-kappaB binding to the iNOS gene promoter [28].
iNOS Binding (binding) of in muscle associated with hyperglycemia and paracetamol
15) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.31 Pain Relevance 0.34
Background values from an equivalent area near each lane were subtracted from each band to calculate mean band density and iNOS or DARPP-32 immunoreactivity was normalized by density of ?
iNOS Binding (immunoreactivity) of in band
16) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2674956 Disease Relevance 0 Pain Relevance 0.03
iNOS (inducible nitric oxide synthase) that reacts with
iNOS Binding (reacts) of
17) Confidence 0.19 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1852887 Disease Relevance 0.68 Pain Relevance 0.24
Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2.
iNOS Binding (binding) of
18) Confidence 0.18 Published 2005 Journal Science Section Abstract Doc Link 16373578 Disease Relevance 0.09 Pain Relevance 0.18
Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.
Inducible nitric oxide synthase Binding (binds) of associated with cox2
19) Confidence 0.18 Published 2005 Journal Science Section Title Doc Link 16373578 Disease Relevance 0.09 Pain Relevance 0.22
Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity.
iNOS Binding (binds) of
20) Confidence 0.13 Published 2005 Journal Science Section Abstract Doc Link 16373578 Disease Relevance 0.10 Pain Relevance 0.17

General Comments

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