INT126227

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 1
Disease Relevance 0.73
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hsp90aa1, Nos1) cytosol (Hsp90aa1, Nos1) unfolded protein binding (Hsp90aa1)
mitochondrion (Nos1) aging (Nos1) intracellular (Hsp90aa1)
Anatomy Link Frequency
medulla 1
Hsp90aa1 (Rattus norvegicus)
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 9 99.02 Very High Very High Very High
anesthesia 1 79.60 Quite High
depression 2 40.64 Quite Low
Disease Link Frequency Relevance Heat
Endotoxemia 5 100.00 Very High Very High Very High
Shock 2 99.48 Very High Very High Very High
Stress 1 90.44 High High
Death 1 72.00 Quite High
Pressure Volume 2 Under Development 1 67.00 Quite High
Heart Rate Under Development 1 66.40 Quite High
Cardiovascular Disorder Under Development 2 41.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the rostral ventrolateral medulla, the 70-kDa heat shock protein (HSP70), but not HSP90, confers neuroprotection against fatal endotoxemia via augmentation of nitric-oxide synthase I (NOS I)/protein kinase G signaling pathway and inhibition of NOS II/peroxynitrite cascade.
HSP90 Positive_regulation (augmentation) of nitric-oxide synthase I in medulla associated with endotoxemia, rostral ventrolateral medulla and shock
1) Confidence 0.03 Published 2005 Journal Mol. Pharmacol. Section Title Doc Link 15827295 Disease Relevance 0.73 Pain Relevance 0.25

General Comments

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