INT126236

Context Info Confidence 0.46 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 2.18 Pain Relevance 1.69

cytosol (NFKBIA) plasma membrane (NFKBIA) nucleus (NFKBIA) enzyme binding (NFKBIA) transcription factor binding (NFKBIA) cytoplasm (NFKBIA)

Anatomy Link Frequency MIA PaCa-2 2 NFKBIA (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 22 99.78 cINOD 9 87.72 COX-2 inhibitor 4 83.40 Inflammation 3 5.00 cytokine 2 5.00 alcohol 1 5.00 abdominal pain 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 145 99.92 Infection 26 96.72 Squamous Cell Carcinoma 6 85.68 Pancreatic Cancer 5 83.36 Cancer 14 81.92 INFLAMMATION 4 76.56 Death 6 5.00 Repression 4 5.00 Sprains And Strains 4 5.00 Retinoblastoma 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Increased levels of I kappa B-alpha protein were detected, especially in MIA PaCa-2 cells, after treatment with parthenolide and sulindac compared with each agent alone.

Positive_regulation (Increased) of Positive_regulation (levels) of I kappa B-alpha in MIA PaCa-2

1) Confidence 0.46 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15827332 Disease Relevance 0.53 Pain Relevance 0.39

The induction of NFKBIA might be a response to the increased levels of NF-?

Positive_regulation (response) of Positive_regulation (induction) of NFKBIA

2) Confidence 0.22 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.37 Pain Relevance 0

Data of Western blot further demonstrated that aspirin treatment caused activation of caspases, down-regulation of Mcl-1 protein, dephosphorylation of ERK-1/2 and AKT, and also IkappaB-alpha proteolysis-dependent NF-kappaB activation in YD-8 cells.

Positive_regulation (caused) of Positive_regulation (activation) of IkappaB-alpha associated with aspirin

3) Confidence 0.05 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.65 Pain Relevance 0.66

Data of Western blot further demonstrated that aspirin treatment caused activation of caspases, down-regulation of Mcl-1 protein, dephosphorylation of ERK-1/2 and AKT, and also IkappaB-alpha proteolysis-dependent NF-kappaB activation in YD-8 cells.

Positive_regulation (dependent) of Positive_regulation (activation) of IkappaB-alpha associated with aspirin

4) Confidence 0.05 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.63 Pain Relevance 0.64

General Comments

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