INT126266

Context Info Confidence 0.57 First Reported 2005 Last Reported 2005 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 4 Disease Relevance 0.96 Pain Relevance 0.95

mitochondrion (Pars2) ligase activity (Pars2) cytoplasm (Pars2)

Anatomy Link Frequency DRG 2 neurons 1 Pars2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Calcitonin gene-related peptide 4 99.24 Inflammation 8 97.44 nociceptor 8 93.40 Peripheral sensitization 4 92.80

Disease Link Frequency Relevance Heat Nociception 4 99.28 INFLAMMATION 8 97.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A double-labeling study of PARs with NF-200 and alpha calcitonin gene-related peptide (CGRP) also revealed the distinctive expression of PARs mRNA in myelinated or nociceptive neurons.

Gene_expression (expression) of PARs mRNA in neurons associated with nociception and calcitonin gene-related peptide

1) Confidence 0.57 Published 2005 Journal Brain Res. Section Abstract Doc Link 15829229 Disease Relevance 0.24 Pain Relevance 0.22

This study shows the precise expression pattern of PARs mRNA in the DRG and indicates that the cells in DRG can receive modulation with different types of proteinase-activated receptors.

Gene_expression (expression) of PARs mRNA in DRG

2) Confidence 0.57 Published 2005 Journal Brain Res. Section Abstract Doc Link 15829229 Disease Relevance 0.23 Pain Relevance 0.21

Here, we investigated the expression of these four members of PARs in the adult rat dorsal root ganglia (DRG) using radioisotope-labeled in situ hybridization histochemistry.

Spec (investigated) Gene_expression (expression) of PARs in DRG

3) Confidence 0.57 Published 2005 Journal Brain Res. Section Abstract Doc Link 15829229 Disease Relevance 0.24 Pain Relevance 0.26

Histological analysis revealed the specific expression patterns of the PARs.

Gene_expression (expression) of PARs

4) Confidence 0.38 Published 2005 Journal Brain Res. Section Abstract Doc Link 15829229 Disease Relevance 0.24 Pain Relevance 0.25

General Comments

This test has worked.