INT126268

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.65
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Tpsab1) extracellular region (Tpsab1) plasma membrane (F2rl1)
signal transducer activity (F2rl1)
Anatomy Link Frequency
mast cell 1
Tpsab1 (Rattus norvegicus)
F2rl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 9 94.96 High High
spastic colon 24 93.96 High High
Peripheral sensitization 1 92.24 High High
nociceptor 2 90.00 High High
antagonist 5 87.68 High High
nud 4 80.36 Quite High
agonist 1 37.92 Quite Low
Calcitonin gene-related peptide 1 34.40 Quite Low
allodynia 2 24.80 Low Low
Hyperalgesia 2 23.76 Low Low
Disease Link Frequency Relevance Heat
Stress 46 96.72 Very High Very High Very High
INFLAMMATION 7 94.96 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

23 93.96 High High
Infection 8 85.60 High High
Dyspepsia 4 80.36 Quite High
Diarrhoea 3 71.00 Quite High
Mucositis 2 43.44 Quite Low
Nociception 1 25.60 Quite Low
Neuropathic Pain 2 24.80 Low Low
Hyperalgesia 2 23.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tryptase released upon mucosal mast cell degranulation can activate PAR2 (26).
Tryptase Positive_regulation (activate) of PAR2 in mast cell
1) Confidence 0.35 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 0.90 Pain Relevance 0.65
Three member of this family (PAR-1, PAR-3, and PAR-4) are considered thrombin receptors, whereas PAR-2 is activated by trypsin and tryptase.
tryptase Positive_regulation (activated) of PAR-2
2) Confidence 0.21 Published 2005 Journal Brain Res. Section Abstract Doc Link 15829229 Disease Relevance 0.18 Pain Relevance 0.22

General Comments

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