INT126276

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.71
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome segregation (Rgs14) cytoplasm (Rgs14) mitosis (Rgs14)
signal transduction (Rgs14) nucleocytoplasmic transport (Rgs14) nucleus (Rgs14)
Anatomy Link Frequency
PAG 1
Rgs14 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 6 99.74 Very High Very High Very High
Delta opioid receptors 2 99.42 Very High Very High Very High
mu opioid receptor 8 98.54 Very High Very High Very High
Central grey 4 97.86 Very High Very High Very High
Morphine 10 96.12 Very High Very High Very High
Intracerebroventricular 2 89.36 High High
tolerance 2 84.24 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 12 98.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In pull-down assays performed on membranes from mouse periaqueductal gray matter (PAG), mu-opioid receptors co-precipitated with delta-opioid receptors, Gi/o/z/q proteins, and the regulators of G-protein signalling RGS4, RGS9-2, RGS14, RGSZ1 and RGSZ2.
Regulation (regulators) of RGS14 in PAG associated with mu opioid receptor, urological neuroanatomy, delta opioid receptors and central grey
1) Confidence 0.39 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15829256 Disease Relevance 0.36 Pain Relevance 0.64
The opioid produced no change in the membrane levels of RGS9-2, RGS14, RGSZ1 and RGSZ2.
Neg (no) Regulation (change) of RGS14 associated with opioid
2) Confidence 0.23 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15829256 Disease Relevance 0.34 Pain Relevance 0.99

General Comments

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