INT126291

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 1.30
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rgs4) plasma membrane (Rgs4) cytoplasm (Rgs4)
Anatomy Link Frequency
nucleus accumbens 2
PAG 2
brachial plexus 2
brainstem 1
Rgs4 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 6 100.00 Very High Very High Very High
medulla 150 99.96 Very High Very High Very High
Morphine 12 99.78 Very High Very High Very High
Spinal cord 125 99.40 Very High Very High Very High
cerebral cortex 35 97.60 Very High Very High Very High
tolerance 2 80.68 Quite High
Thalamus 5 78.72 Quite High
Intracerebroventricular 2 78.68 Quite High
mu opioid receptor 8 78.08 Quite High
Central grey 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 12 100.00 Very High Very High Very High
Nervous System Injury 45 98.48 Very High Very High Very High
Stress 5 93.84 High High
Shock 5 89.00 High High
INFLAMMATION 15 39.12 Quite Low
Adhesions 5 37.04 Quite Low
Alzheimer's Dementia 5 19.32 Low Low
Pain 5 5.00 Very Low Very Low Very Low
Nerve Root Compression 5 5.00 Very Low Very Low Very Low
Decapitation 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, when RGS2 was phosphorylated by PKC, GAP activity was reduced, then Gq/11 signals were enhanced [41]; RGS16 phosphorylation could also reduce its GAP activity toward GRi/o and result in increased adrenergic receptor signals [42], then the paralleled increase in RGS4 and PKA induced by brachial plexus avulsion will be expected to unmask their full functional potential, the orchestrated and dynamical RGS4 subcellular distribution and modulation will be the intriguing intracellular signal in response to brachial plexus avulsion.
Positive_regulation (increase) of RGS4 in brachial plexus
1) Confidence 0.67 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC3017042 Disease Relevance 0 Pain Relevance 0.19
METHODS: In this study, we use constitutive and nucleus accumbens-inducible RGS4 knockout mice as well as mice overexpressing RGS4 in the nucleus accumbens via viral mediated gene transfer, to examine the influence of RGS4 on behavioral responses to opiates.
Spec (examine) Positive_regulation (inducible) of RGS4 in nucleus accumbens
2) Confidence 0.50 Published 2010 Journal Biol. Psychiatry Section Body Doc Link 19914603 Disease Relevance 0 Pain Relevance 0
As illustrated in Figure 2, RGS4 and PKAC?
Positive_regulation (illustrated) of RGS4
3) Confidence 0.49 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC3017042 Disease Relevance 0 Pain Relevance 0.36
and RGS4 were induced by brachial plexus avulsion.
Positive_regulation (induced) of RGS4 in brachial plexus
4) Confidence 0.45 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC3017042 Disease Relevance 0.18 Pain Relevance 0.15
However, in brainstem, elevated RGS4 was mainly concentrated in non-membrane fraction, the relative densities to control were 1.05 ± 0.23, 3.03 ± 0.52, 2.90 ± 0.38 folds of control in the three time points.


Positive_regulation (elevated) of RGS4 in brainstem associated with medulla
5) Confidence 0.45 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC3017042 Disease Relevance 0.19 Pain Relevance 0.28
and RGS4 are among the upregulated genes.
Positive_regulation (upregulated) of RGS4
6) Confidence 0.45 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC3017042 Disease Relevance 0.16 Pain Relevance 0.13
METHODS: In this study, we use constitutive and nucleus accumbens-inducible RGS4 knockout mice as well as mice overexpressing RGS4 in the nucleus accumbens via viral mediated gene transfer, to examine the influence of RGS4 on behavioral responses to opiates.
Spec (examine) Positive_regulation (inducible) of RGS4 in nucleus accumbens
7) Confidence 0.44 Published 2010 Journal Biol. Psychiatry Section Body Doc Link 19914603 Disease Relevance 0 Pain Relevance 0
Morphine treatment recruited RGS4 to the PAG membranes, and 30 min and 3 h after the opioid challenge its association with mu receptors had increased.
Positive_regulation (increased) of RGS4 in PAG associated with urological neuroanatomy, opioid and morphine
8) Confidence 0.44 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15829256 Disease Relevance 0.38 Pain Relevance 1.05
Morphine treatment recruited RGS4 to the PAG membranes, and 30 min and 3 h after the opioid challenge its association with mu receptors had increased.
Positive_regulation (recruited) of RGS4 in PAG associated with urological neuroanatomy, opioid and morphine
9) Confidence 0.44 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15829256 Disease Relevance 0.38 Pain Relevance 1.03

General Comments

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