INT126299

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.89
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Rgs20) plasma membrane (Rgs20) nucleus (Rgs20)
cytoplasm (Rgs20)
Anatomy Link Frequency
PAG 1
neurons 1
Rgs20 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 20 99.74 Very High Very High Very High
Delta opioid receptors 3 99.42 Very High Very High Very High
opioid receptor 84 98.56 Very High Very High Very High
mu opioid receptor 8 98.54 Very High Very High Very High
Central grey 4 97.86 Very High Very High Very High
Morphine 87 96.80 Very High Very High Very High
tolerance 30 96.32 Very High Very High Very High
Analgesic 19 95.92 Very High Very High Very High
Glutamate 10 92.28 High High
Intracerebroventricular 5 89.92 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 30 98.10 Very High Very High Very High
Nociception 7 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Intractable Pain 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Herpes Simplex Virus Infection 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In pull-down assays performed on membranes from mouse periaqueductal gray matter (PAG), mu-opioid receptors co-precipitated with delta-opioid receptors, Gi/o/z/q proteins, and the regulators of G-protein signalling RGS4, RGS9-2, RGS14, RGSZ1 and RGSZ2.
Regulation (regulators) of RGSZ1 in PAG associated with mu opioid receptor, urological neuroanatomy, delta opioid receptors and central grey
1) Confidence 0.41 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15829256 Disease Relevance 0.36 Pain Relevance 0.65
The opioid produced no change in the membrane levels of RGS9-2, RGS14, RGSZ1 and RGSZ2.
Neg (no) Regulation (change) of RGSZ1 associated with opioid
2) Confidence 0.24 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15829256 Disease Relevance 0.34 Pain Relevance 0.99
In neurons, histidine triad nucleotide binding protein 1 (HINT1) connects the regulators of G protein signaling RGSZ1 and RGSZ2 to the C terminus of the MOR.
Regulation (regulators) of RGSZ1 in neurons associated with opioid receptor
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890584 Disease Relevance 0.18 Pain Relevance 0.87

General Comments

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