INT12631

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Context Info
Confidence 0.45
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 6.13
Pain Relevance 6.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
caudate nucleus 8
globus pallidus 4
putamen 2
neocortex 2
medial 2
INSRR (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 50 100.00 Very High Very High Very High
opioid receptor 11 100.00 Very High Very High Very High
adenocard 21 99.90 Very High Very High Very High
positron emission tomography 4 99.72 Very High Very High Very High
Dopamine 21 99.52 Very High Very High Very High
Cannabinoid 28 99.20 Very High Very High Very High
mu opioid receptor 1 98.88 Very High Very High Very High
Pain 7 97.88 Very High Very High Very High
primary somatosensory cortex 1 95.76 Very High Very High Very High
Opioid 5 94.96 High High
Disease Link Frequency Relevance Heat
Epilepsy 4 98.14 Very High Very High Very High
Disease 95 98.00 Very High Very High Very High
Pain 6 97.88 Very High Very High Very High
Malformations Of Cortical Development 2 91.88 High High
Dyskinesias 5 89.28 High High
Congenital Anomalies 1 81.60 Quite High
Frailty 1 79.32 Quite High
Sclerosis 1 72.72 Quite High
Partial Seizures 1 61.88 Quite High
Generalized Epilepsy 4 59.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, advanced grades of Huntington's disease showed an almost total loss of CB(1) receptors and the further depletion of D(1) receptors in the caudate nucleus, putamen and globus pallidus internus, and an increase in GABA(A) receptor binding in the globus pallidus internus.
Positive_regulation (increase) of ) receptor Binding (binding) of in globus pallidus associated with gaba and disease
1) Confidence 0.45 Published 2000 Journal Neuroscience Section Abstract Doc Link 10828533 Disease Relevance 0.65 Pain Relevance 0.86
First, the very early stages of the disease (grade 0) were characterized by a major loss of cannabinoid CB(1), dopamine D(2) and adenosine A(2a) receptor binding in the caudate nucleus, putamen and globus pallidus externus and an increase in GABA(A) receptor binding in the globus pallidus externus.
Positive_regulation (increase) of ) receptor Binding (binding) of in caudate nucleus associated with gaba, adenocard, dopamine, cannabinoid and disease
2) Confidence 0.32 Published 2000 Journal Neuroscience Section Abstract Doc Link 10828533 Disease Relevance 0.57 Pain Relevance 0.57
First, the very early stages of the disease (grade 0) were characterized by a major loss of cannabinoid CB(1), dopamine D(2) and adenosine A(2a) receptor binding in the caudate nucleus, putamen and globus pallidus externus and an increase in GABA(A) receptor binding in the globus pallidus externus.
Positive_regulation (increase) of ) receptor Binding (binding) of in caudate nucleus associated with gaba, adenocard, dopamine, cannabinoid and disease
3) Confidence 0.30 Published 2000 Journal Neuroscience Section Abstract Doc Link 10828533 Disease Relevance 0.56 Pain Relevance 0.56
High levels of opioid receptor binding were seen in the cortical projections of the medial pain system in the cingulate and prefrontal cortex as has previously been observed in post-mortem studies.
Positive_regulation (levels) of receptor Binding (binding) of in medial associated with pain and opioid receptor
4) Confidence 0.26 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1650933 Disease Relevance 0.27 Pain Relevance 0.77
The SPM approach confirmed reduced availability in these areas and, in addition, showed decreased cingulate and increased prefrontal opioid receptor binding in the dyskinetic patients.
Positive_regulation (increased) of receptor Binding (binding) of in prefrontal associated with opioid receptor
5) Confidence 0.25 Published 1997 Journal Ann. Neurol. Section Abstract Doc Link 9392571 Disease Relevance 0.88 Pain Relevance 0.60
First, the very early stages of the disease (grade 0) were characterized by a major loss of cannabinoid CB(1), dopamine D(2) and adenosine A(2a) receptor binding in the caudate nucleus, putamen and globus pallidus externus and an increase in GABA(A) receptor binding in the globus pallidus externus.
Positive_regulation (increase) of ) receptor in putamen Binding (binding) of in caudate nucleus associated with gaba, adenocard, dopamine, cannabinoid and disease
6) Confidence 0.11 Published 2000 Journal Neuroscience Section Abstract Doc Link 10828533 Disease Relevance 0.57 Pain Relevance 0.57
First, the very early stages of the disease (grade 0) were characterized by a major loss of cannabinoid CB(1), dopamine D(2) and adenosine A(2a) receptor binding in the caudate nucleus, putamen and globus pallidus externus and an increase in GABA(A) receptor binding in the globus pallidus externus.
Positive_regulation (increase) of ) receptor in globus pallidus Binding (binding) of in caudate nucleus associated with gaba, adenocard, dopamine, cannabinoid and disease
7) Confidence 0.11 Published 2000 Journal Neuroscience Section Abstract Doc Link 10828533 Disease Relevance 0.57 Pain Relevance 0.57
First, the very early stages of the disease (grade 0) were characterized by a major loss of cannabinoid CB(1), dopamine D(2) and adenosine A(2a) receptor binding in the caudate nucleus, putamen and globus pallidus externus and an increase in GABA(A) receptor binding in the globus pallidus externus.
Positive_regulation (increase) of ) receptor in globus pallidus Binding (binding) of in caudate nucleus associated with gaba, adenocard, dopamine, cannabinoid and disease
8) Confidence 0.10 Published 2000 Journal Neuroscience Section Abstract Doc Link 10828533 Disease Relevance 0.56 Pain Relevance 0.56
First, the very early stages of the disease (grade 0) were characterized by a major loss of cannabinoid CB(1), dopamine D(2) and adenosine A(2a) receptor binding in the caudate nucleus, putamen and globus pallidus externus and an increase in GABA(A) receptor binding in the globus pallidus externus.
Positive_regulation (increase) of ) receptor in putamen Binding (binding) of in caudate nucleus associated with gaba, adenocard, dopamine, cannabinoid and disease
9) Confidence 0.10 Published 2000 Journal Neuroscience Section Abstract Doc Link 10828533 Disease Relevance 0.56 Pain Relevance 0.56
In patients with mesial temporal lobe epilepsy, upregulation of mu opioid receptors has been found in lateral neocortex without an overall increase of opioid receptor binding.
Neg (without) Positive_regulation (increase) of receptor Binding (binding) of in neocortex associated with epilepsy, mu opioid receptor and opioid receptor
10) Confidence 0.02 Published 1999 Journal Adv Neurol Section Abstract Doc Link 10514872 Disease Relevance 0.84 Pain Relevance 0.39
This inversion of fimS requires either or site-specific recombinases binding at IRL and IRR [29],[47],[48].
Positive_regulation (requires) of IRR Binding (binding) of
11) Confidence 0.01 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2845655 Disease Relevance 0.07 Pain Relevance 0

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