INT126322

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.12
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TGFBI) extracellular space (TGFBI) extracellular region (TGFBI)
plasma membrane (TGFBI) extracellular matrix organization (TGFBI)
TGFBI (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 16 100.00 Very High Very High Very High
antagonist 4 99.32 Very High Very High Very High
beta blocker 1 94.92 High High
Clonidine 1 92.04 High High
agonist 4 91.64 High High
Migraine 7 78.80 Quite High
ischemia 1 72.24 Quite High
Pain 4 41.20 Quite Low
Disease Link Frequency Relevance Heat
Depression 16 100.00 Very High Very High Very High
Recurrence 9 92.88 High High
Headache 6 78.80 Quite High
Epilepsy 2 73.44 Quite High
Brain Hemorrhage 1 72.24 Quite High
Corneal Opacity 1 67.32 Quite High
Amyloidosis 3 58.92 Quite High
Low Vision 1 50.12 Quite High
Injury 1 25.24 Quite Low
Adhesions 5 11.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Haplotypes were constructed using the TGFBI locus markers D5S816, D5S393, and the c.1702G>C and c.1706T>A variants in Family 1.


Negative_regulation (using) of TGFBI
1) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2822555 Disease Relevance 0.13 Pain Relevance 0
The CSD blockade by the alpha(2)-antagonist yohimbine (1.75 mmol/L) was because of its action on inhibitory 5-HT(1A) receptors.
Negative_regulation (blockade) of CSD associated with depression and antagonist
2) Confidence 0.36 Published 2005 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 15829916 Disease Relevance 1.12 Pain Relevance 1.23
While visual loss with CDB1 is described as early and marked [1,2,5], with CDB2 it is later and moderate [3,5].
Negative_regulation (loss) of CDB1
3) Confidence 0.36 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2518171 Disease Relevance 0.14 Pain Relevance 0
This study suggests that the mode of action of metoprolol in prophylaxis is not via direct CSD inhibition.
Negative_regulation (inhibition) of CSD associated with depression
4) Confidence 0.35 Published 2007 Journal Cephalalgia Section Abstract Doc Link 17681024 Disease Relevance 0.73 Pain Relevance 0.40

General Comments

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