INT126334

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 8.68
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf10b)
Anatomy Link Frequency
natural killer cell 3
Tnfrsf10b (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 7 99.62 Very High Very High Very High
Analgesic 1 99.40 Very High Very High Very High
cva 30 96.20 Very High Very High Very High
cINOD 32 93.76 High High
rheumatoid arthritis 128 89.76 High High
Inflammation 86 88.92 High High
cytokine 14 85.84 High High
Neuropeptide 1 77.80 Quite High
antagonist 4 73.72 Quite High
corticosteroid 17 50.00 Quite Low
Disease Link Frequency Relevance Heat
Death 33 100.00 Very High Very High Very High
Hemorrhagic Shock 51 99.82 Very High Very High Very High
Apoptosis 170 99.70 Very High Very High Very High
Pseudomonas Infection 2 99.24 Very High Very High Very High
Infection 6 98.32 Very High Very High Very High
Hemorrhage 26 96.20 Very High Very High Very High
Cardiovascular Disease 160 94.84 High High
Cancer 185 92.64 High High
Disease 61 92.52 High High
Lymphatic System Cancer 2 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Substance P regulates natural killer cell interferon-gamma production and resistance to Pseudomonas aeruginosa infection.
Gene_expression (production) of killer in natural killer cell associated with pseudomonas infection, infection and substance p
1) Confidence 0.58 Published 2005 Journal Eur. J. Immunol. Section Title Doc Link 15832292 Disease Relevance 0.71 Pain Relevance 0.52
Despite their resistance to TRAIL (recombinant TRAIL protein or Ad-stTRAIL), U373-MG and ACBRI371 cells expressed TRAIL receptors DR4 and DR5 (data not shown).
Gene_expression (expressed) of DR5
2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2641005 Disease Relevance 0.96 Pain Relevance 0
Hemorrhagic shock-induced death receptor expression
Gene_expression (expression) of death receptor associated with hemorrhagic shock and death
3) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2374615 Disease Relevance 1.24 Pain Relevance 0.14
(Park et al 1997), cytotoxic capabilities, and expression of natural killer cell markers including CD56 (Michel et al 2007) and killer immunoglobulin-like receptors.
Gene_expression (expression) of killer in natural killer cell
4) Confidence 0.08 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515420 Disease Relevance 1.14 Pain Relevance 0.25
(Park et al 1997), cytotoxic capabilities, and expression of natural killer cell markers including CD56 (Michel et al 2007) and killer immunoglobulin-like receptors.
Gene_expression (expression) of killer in natural killer cell
5) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515420 Disease Relevance 1.12 Pain Relevance 0.25
In contrast, COX inhibitors were able to restore death receptor-5 expression.
Gene_expression (expression) of death receptor-5 associated with death
6) Confidence 0.05 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.32 Pain Relevance 0.27
VPA-induced apoptosis, via the extrinsic pathway involving engagement of the caspase-8-dependent cascade, sensitizes cells to TRAIL/Apo2L-mediated apoptosis by increasing expression of DR4 and DR5 by 3- and 14-fold, respectively.
Gene_expression (expression) of DR5 associated with apoptosis
7) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.88 Pain Relevance 0
These include depolarization of the mitochondrial membrane potential, enhanced expression of the death receptor CD95 and its ligand, followed by activation of the caspase cascade [28-30].
Gene_expression (expression) of death receptor CD95 associated with death
8) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.31 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox