INT126335

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Context Info
Confidence 0.07
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 6.22
Pain Relevance 5.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) extracellular space (Tac1) extracellular region (Tac1)
plasma membrane (Tac1) nucleus (Pax3) DNA binding (Pax3)
Anatomy Link Frequency
nerves 2
Pax3 (Mus musculus)
Tac1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 275 100.00 Very High Very High Very High
substance P 269 100.00 Very High Very High Very High
Neuropeptide 17 100.00 Very High Very High Very High
antagonist 11 99.50 Very High Very High Very High
Crohn's disease 50 99.20 Very High Very High Very High
cytokine 99 96.16 Very High Very High Very High
Neurotransmitter 18 95.60 Very High Very High Very High
Serotonin 6 69.52 Quite High
Analgesic 1 25.00 Low Low
Inflammatory response 8 22.28 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 257 100.00 Very High Very High Very High
Targeted Disruption 170 100.00 Very High Very High Very High
Schistosomiasis 8 99.80 Very High Very High Very High
Granulomatous Inflammation 16 99.28 Very High Very High Very High
Disease 80 99.20 Very High Very High Very High
Granuloma 368 97.76 Very High Very High Very High
Communicable Diseases 4 96.92 Very High Very High Very High
Increased Venous Pressure Under Development 6 92.16 High High
Corneal Perforation 1 91.44 High High
Neurogenic Inflammation 2 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, since NK1 binds only SP and not neurokinin A and the results in NK1-knockout mice mirror the findings in SP-knockout mice, we are confident in attributing reduced granuloma formation and proinflammatory cytokine production to the absence of SP signaling and not to reduced or absent neurokinin A signaling.
SP Binding (binds) of NK1 associated with targeted disruption, granuloma, cytokine and substance p
1) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 0.77 Pain Relevance 0.79
However, since NK1 binds only SP and not neurokinin A and the results in NK1-knockout mice mirror the findings in SP-knockout mice, we are confident in attributing reduced granuloma formation and proinflammatory cytokine production to the absence of SP signaling and not to reduced or absent neurokinin A signaling.
SP Binding (binds) of NK1 associated with targeted disruption, granuloma, cytokine and substance p
2) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 0.73 Pain Relevance 0.75
Preprotachykinin protein is cleaved to form two active neuropeptides, SP and neurokinin A.
SP Binding (form) of Preprotachykinin associated with neuropeptide and substance p
3) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 0.45 Pain Relevance 0.79
For example, granulomatous inflammation in murine schistosomiasis requires binding of SP to NK1 [30].
SP Binding (binding) of NK1 associated with granulomatous inflammation, inflammation, schistosomiasis and substance p
4) Confidence 0.06 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 1.31 Pain Relevance 0.68
To this end, mice were treated with the SP antagonist, spantide I that blocks SP interaction with neurokinin-1, its major receptor.
SP Binding (interaction) of neurokinin-1 associated with antagonist and substance p
5) Confidence 0.01 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15832292 Disease Relevance 0.66 Pain Relevance 0.49
Substance P (SP), which belongs to a family of structurally linked peptides known as tachykinins, is an 11-amino acid peptide secreted by nerves and inflammatory cells such as monocytes, macrophages, eosinophils, and lymphocytes, and acts by binding to the neurokinin-1 (NK-1) receptor [28].
SP Binding (binding) of neurokinin-1 in nerves associated with inflammation and substance p
6) Confidence 0.00 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.15 Pain Relevance 0.88
Substance P (SP), which belongs to a family of structurally linked peptides known as tachykinins, is an 11-amino acid peptide secreted by nerves and inflammatory cells such as monocytes, macrophages, eosinophils, and lymphocytes, and acts by binding to the neurokinin-1 (NK-1) receptor [28].
SP Binding (binding) of NK-1 in nerves associated with inflammation and substance p
7) Confidence 0.00 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.15 Pain Relevance 0.88

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