INT126367

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Context Info
Confidence 0.04
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.57
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSB) mitochondrion (CTSB) extracellular space (CTSB)
extracellular region (CTSB) intracellular (CTSB) lysosome (CTSB)
CTSB (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 93.60 High High
Eae 12 88.16 High High
cytokine 14 78.88 Quite High
long-term potentiation 2 71.08 Quite High
corticosteroid 1 69.64 Quite High
Hippocampus 8 64.72 Quite High
cerebral cortex 4 63.52 Quite High
Spinal cord 3 5.00 Very Low Very Low Very Low
Pyramidal cell 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 48 96.60 Very High Very High Very High
Toxicity 10 93.76 High High
Alzheimer's Dementia 17 93.40 High High
Coagulation Disorder 1 93.12 High High
Neuroblastoma 2 84.48 Quite High
Necrosis 1 77.52 Quite High
Cancer 1 77.16 Quite High
Disease 89 75.40 Quite High
Injury 6 59.92 Quite High
Anorexia 1 59.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-secretase, one of the enzymes that cleaves APP, which could probably be the underlying mechanism of the A?
Positive_regulation (cleaves) of Gene_expression (one) of secretase
1) Confidence 0.04 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 0.68 Pain Relevance 0.14
Synthesis of the major APPs can be increased up to 1000-fold over normal levels under acute-phase conditions.
Positive_regulation (increased) of Gene_expression (Synthesis) of APPs
2) Confidence 0.04 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.57 Pain Relevance 0.10
These compounds seem to target the gamma-secretase complex, increasing gamma-secretase-catalyzed production of Abeta42 in vitro.
Positive_regulation (increasing) of Gene_expression (production) of gamma-secretase
3) Confidence 0.01 Published 2005 Journal Nat. Med. Section Abstract Doc Link 15834426 Disease Relevance 0.31 Pain Relevance 0.27

General Comments

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