INT126368

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2005
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 7.20
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MSX2) transcription factor binding (MSX2) cytoplasm (MSX2)
Anatomy Link Frequency
PFM 5
osteoblast 4
body segments 1
foot 1
MSX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 30 99.16 Very High Very High Very High
cINOD 7 97.36 Very High Very High Very High
metalloproteinase 2 94.08 High High
imagery 3 91.12 High High
Pain 8 40.56 Quite Low
vaginimus 6 10.00 Low Low
Spinal cord 8 5.00 Very Low Very Low Very Low
dexamethasone 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 50 100.00 Very High Very High Very High
Heterotopic Ossification 174 99.32 Very High Very High Very High
Low Back Pain 32 99.16 Very High Very High Very High
Cytomegalovirus Infection 2 96.80 Very High Very High Very High
Obesity 15 92.04 High High
Stress Fractures 8 86.24 High High
Stress Incontinence 10 85.80 High High
Calcification 10 84.84 Quite High
Alzheimer's Dementia 4 84.36 Quite High
Targeted Disruption 24 77.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compounds devoid of COX activity and the endogenous isoprenoids FPP and GGPP also raised Abeta42.
Gene_expression (raised) of FPP
1) Confidence 0.65 Published 2005 Journal Nat. Med. Section Abstract Doc Link 15834426 Disease Relevance 0.30 Pain Relevance 0.28
The purpose of this study was to investigate the PFM function in women with and without LBP using transabdominal ultrasound.
Spec (investigate) Gene_expression (function) of PFM in PFM associated with backache
2) Confidence 0.57 Published 2010 Journal Man Ther Section Abstract Doc Link 20089440 Disease Relevance 0.86 Pain Relevance 0.67
Statistical analysis (Independent t-test) revealed significant difference in transabdominal ultrasound measurements for PFM function between the two groups (P = 0.04, 95% CI of difference: 0.002-0.27).
Gene_expression (function) of PFM in PFM
3) Confidence 0.57 Published 2010 Journal Man Ther Section Abstract Doc Link 20089440 Disease Relevance 0.95 Pain Relevance 0.83
The results of this study indicate PFM dysfunction in individuals with LBP compared to those without LBP.
Gene_expression (dysfunction) of PFM in PFM associated with backache
4) Confidence 0.57 Published 2010 Journal Man Ther Section Abstract Doc Link 20089440 Disease Relevance 0.94 Pain Relevance 0.84
Women with PVD had higher PFM tone, decreased PFM flexibility and lower PFM relaxation capacity compared with control women.
Gene_expression (flexibility) of PFM in PFM
5) Confidence 0.57 Published 2010 Journal J Sex Med Section Body Doc Link 20059663 Disease Relevance 0 Pain Relevance 0
Women with PVD had higher PFM tone, decreased PFM flexibility and lower PFM relaxation capacity compared with control women.
Gene_expression (flexibility) of PFM in PFM
6) Confidence 0.57 Published 2010 Journal J Sex Med Section Body Doc Link 20059663 Disease Relevance 0 Pain Relevance 0
We performed Real-time RT-PCR assays to detect the expression levels of osteoblast specific marker genes MSX2 (homeobox gene MSX2), VDR (vitamin D receptor), COL1A1 (collagen 1A1), ALPL (alkaline phosphatase), SPARC (osteonectin), SPP1 (osteopontin) and BGLAP (osteocalcin) to prove the osteoblast phenotype.
Gene_expression (detect) of MSX2 in osteoblast associated with osteoporosis
7) Confidence 0.50 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.54 Pain Relevance 0
We performed Real-time RT-PCR assays to detect the expression levels of osteoblast specific marker genes MSX2 (homeobox gene MSX2), VDR (vitamin D receptor), COL1A1 (collagen 1A1), ALPL (alkaline phosphatase), SPARC (osteonectin), SPP1 (osteopontin) and BGLAP (osteocalcin) to prove the osteoblast phenotype.
Gene_expression (expression) of MSX2 in osteoblast associated with osteoporosis
8) Confidence 0.50 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.54 Pain Relevance 0
We performed Real-time RT-PCR assays to detect the expression levels of osteoblast specific marker genes MSX2 (homeobox gene MSX2), VDR (vitamin D receptor), COL1A1 (collagen 1A1), ALPL (alkaline phosphatase), SPARC (osteonectin), SPP1 (osteopontin) and BGLAP (osteocalcin) to prove the osteoblast phenotype.
Gene_expression (expression) of MSX2 in osteoblast associated with osteoporosis
9) Confidence 0.50 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.54 Pain Relevance 0
We performed Real-time RT-PCR assays to detect the expression levels of osteoblast specific marker genes MSX2 (homeobox gene MSX2), VDR (vitamin D receptor), COL1A1 (collagen 1A1), ALPL (alkaline phosphatase), SPARC (osteonectin), SPP1 (osteopontin) and BGLAP (osteocalcin) to prove the osteoblast phenotype.
Gene_expression (detect) of MSX2 in osteoblast associated with osteoporosis
10) Confidence 0.50 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.54 Pain Relevance 0
Given that we standardized arm swing within subject and across conditions, the greater PFM values observed for some participants in the EXT condition suggests the existence of transverse plane movement modifications employed by other body segments.
Gene_expression (values) of PFM in body segments
11) Confidence 0.28 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2733135 Disease Relevance 0.09 Pain Relevance 0
This was done in two ways: first, r was calculated between the 'absolute' foot rotation angle in each condition and the corresponding PFM and IMP values obtained.
Gene_expression (values) of PFM in foot
12) Confidence 0.28 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2733135 Disease Relevance 0 Pain Relevance 0
In fact, overexpression of MSX2, a BMP target gene, can induce an HO-like phenotype.
Gene_expression (overexpression) of MSX2 associated with heterotopic ossification
13) Confidence 0.21 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 0.94 Pain Relevance 0.04
MSX2 overexpression elicited the phenotype under control of either an ubiquitous promoter, such as CMV, a tissue specific promoter, such as TIMPl (tissue inhibitor of metalloproteinase 1), or the endogenous MSX2 promoter [35, 62].
Gene_expression (overexpression) of MSX2 associated with metalloproteinase and cytomegalovirus infection
14) Confidence 0.21 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 0.98 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox