INT126374

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.67
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Gli3) intracellular (Gli3) cilium (Gli3)
DNA binding (Gli3) cytoplasm (Gli3) cytosol (Gli3)
Anatomy Link Frequency
articular 1
finger 1
ventral 1
Gli3 (Mus musculus)
Pain Link Frequency Relevance Heat
Painful diabetic neuropathy 27 100.00 Very High Very High Very High
diabetic neuropathy 4 99.68 Very High Very High Very High
tolerance 1 96.96 Very High Very High Very High
Snapping jaw 7 94.84 High High
Dynorphin 5 90.48 High High
Neuropathic pain 4 87.28 High High
allodynia 39 84.24 Quite High
Hyperalgesia 6 83.12 Quite High
Pain 22 74.76 Quite High
Inflammatory mediators 8 69.76 Quite High
Disease Link Frequency Relevance Heat
Diabetic Neuropathy 36 100.00 Very High Very High Very High
Impaired Glucose Tolerance 1 97.64 Very High Very High Very High
Synovial Chondromatosis 8 97.16 Very High Very High Very High
Diabetes Mellitus 44 95.24 Very High Very High Very High
Temporomandibular Joint Syndrome 7 94.84 High High
Disease 9 92.56 High High
Neuropathic Pain 48 87.28 High High
Neuropathy 1 86.08 High High
Hyperalgesia 7 83.12 Quite High
Cancer 2 80.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine if hedgehog-mediated transcription predisposes to synovial chondromatosis, the extra-toes mutant mouse, which harbours a heterozygous mutation in the hedgehog transcriptional repressor, Gli3, resulting in decreased expression of Gli3 protein, was studied.
Gene_expression (expression) of Gli3 associated with synovial chondromatosis
1) Confidence 0.77 Published 2005 Journal J. Pathol. Section Abstract Doc Link 15834844 Disease Relevance 0.79 Pain Relevance 0.07
In wild-type mouse embryos, Ihh expression was already strong in condylar cartilage by embryonic day (E) 15.5, and expression of Ihh receptors and effector genes (Gli1, Gli2, Gli3, and PTHrP) indicated that Ihh range of action normally reached apical condylar tissue layers, including polymorphic chondroprogenitor layer and articular disc primordia.
Gene_expression (expression) of Gli3 in articular
2) Confidence 0.71 Published 2007 Journal Dev. Dyn. Section Abstract Doc Link 17191253 Disease Relevance 0.43 Pain Relevance 0.43
PDN is detected more frequently in patients with prediabetic condition or impaired glucose tolerance than in patients with late-stage diabetes [5].
Gene_expression (detected) of PDN associated with painful diabetic neuropathy, diabetes mellitus, tolerance and impaired glucose tolerance
3) Confidence 0.30 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 2.34 Pain Relevance 1.47
Notably absent from the list of repressed targets are SSTFs that are known to be expressed specifically in nascent postmitotic ventral interneurons (Evx1, Evx2, En1, Chx10, Sim1, Sox14, Etv1, Etv4, Gata2, Gata3), motor neurons (Isl2, Lhx3, Lhx4, Hlxb9 (Hb9, MNR2)), or the ventral progenitor laminae (Dbx1, Dbx2, Nkx6.2, Nkx6.1, Irx3, Olig1, Olig2, Nkx2.2, Nkx2.9, Pax6, Gli1, Gli2, Gli3).
Gene_expression (expressed) of Gli3 in ventral
4) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
Another important feature of the ATRX protein is the presence, at the N terminal, of a zinc finger domain (called the ADD domain), which is related to sequences seen in the DNA methyltransferase 3 (DNMT3) family of de novo DNA methyltransferases [21].
Gene_expression (presence) of ADD in finger
5) Confidence 0.07 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1464382 Disease Relevance 0.12 Pain Relevance 0
Here, we demonstrate neuroendocrine expression of the calcium-binding downstream regulatory element antagonistic modulator (DREAM) and its role in glucose-dependent regulation of prodynorphin (PDN) expression.
Gene_expression (expression) of PDN
6) Confidence 0.04 Published 2006 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 16621893 Disease Relevance 0 Pain Relevance 0.05

General Comments

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