INT126376

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.52
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gli1) intracellular (Gli1) cilium (Gli1)
DNA binding (Gli1) cytoplasm (Gli1) cytosol (Gli1)
Anatomy Link Frequency
articular 1
tail 1
keratinocytes 1
ventral 1
Gli1 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 4 97.84 Very High Very High Very High
Snapping jaw 7 94.84 High High
Pain 2 93.84 High High
melanocortin 1 receptor 5 79.80 Quite High
Inflammation 5 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
substantia gelatinosa 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 15 99.96 Very High Very High Very High
Targeted Disruption 11 99.88 Very High Very High Very High
Synovial Chondromatosis 8 98.00 Very High Very High Very High
Skin Cancer 240 97.84 Very High Very High Very High
Disease 21 97.60 Very High Very High Very High
Temporomandibular Joint Syndrome 7 94.84 High High
Arthropathy 1 94.60 High High
Pain 2 93.84 High High
Sunburn 115 92.68 High High
Benign Prostatic Hypertrophy 115 92.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For transformation assays, pLTR-GLI1 expression constructs containing each of the haplotypes in the pLTR-2 vector were prepared [18].
Gene_expression (expression) of GLI1
1) Confidence 0.68 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2789726 Disease Relevance 0 Pain Relevance 0
g of each of the pLTR-GLI1 constructs using 12 ?
Gene_expression (constructs) of GLI1
2) Confidence 0.68 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2789726 Disease Relevance 0.12 Pain Relevance 0
For CAT assays, GLI1 cDNA expression constructs that included nucleotides 231 through the polyA tail were prepared in the pM plasmid (Clontech, Palo Alto, CA) for each of four haplotypes (c.2798G>A and c.3298G>C).
Gene_expression (expression) of GLI1 in tail
3) Confidence 0.68 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2789726 Disease Relevance 0.21 Pain Relevance 0
Indeed, transgenic mice expressing GLI1 in cutaneous keratinocytes develop BCCs, providing evidence that GLI1 plays a role in the genesis of BCC [9].
Gene_expression (expressing) of GLI1 in keratinocytes associated with targeted disruption and skin cancer
4) Confidence 0.60 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2789726 Disease Relevance 1.05 Pain Relevance 0.08
Since GLI1 expression appears to play a fundamental role in the genesis of BCC, we determined whether any of the GLI1 genotypes represent risk factors for developing BCC alone or in combination with past sun exposure patterns and whether functional differences exist among the haplotypes.
Gene_expression (expression) of GLI1 associated with sunburn and skin cancer
5) Confidence 0.60 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2789726 Disease Relevance 0.92 Pain Relevance 0.05
Compatible with our observations, expression of GLI1 was reported to increase in mouse prostate after the withdrawal of androgen [41].
Gene_expression (expression) of GLI1 associated with withdrawal
6) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 1.08 Pain Relevance 0.05
In wild-type mouse embryos, Ihh expression was already strong in condylar cartilage by embryonic day (E) 15.5, and expression of Ihh receptors and effector genes (Gli1, Gli2, Gli3, and PTHrP) indicated that Ihh range of action normally reached apical condylar tissue layers, including polymorphic chondroprogenitor layer and articular disc primordia.
Gene_expression (expression) of Gli1 in articular
7) Confidence 0.54 Published 2007 Journal Dev. Dyn. Section Abstract Doc Link 17191253 Disease Relevance 0.43 Pain Relevance 0.43
Because dysregulation of hedgehog signalling is a feature of several benign cartilaginous tumours, expression of the hedgehog target genes PTC1 and GLI1 was examined in this study in samples from human synovial chondromatosis.
Spec (examined) Gene_expression (expression) of GLI1 associated with cancer and synovial chondromatosis
8) Confidence 0.49 Published 2005 Journal J. Pathol. Section Abstract Doc Link 15834844 Disease Relevance 0.72 Pain Relevance 0.09
Notably absent from the list of repressed targets are SSTFs that are known to be expressed specifically in nascent postmitotic ventral interneurons (Evx1, Evx2, En1, Chx10, Sim1, Sox14, Etv1, Etv4, Gata2, Gata3), motor neurons (Isl2, Lhx3, Lhx4, Hlxb9 (Hb9, MNR2)), or the ventral progenitor laminae (Dbx1, Dbx2, Nkx6.2, Nkx6.1, Irx3, Olig1, Olig2, Nkx2.2, Nkx2.9, Pax6, Gli1, Gli2, Gli3).
Gene_expression (expressed) of Gli1 in ventral
9) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0

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