INT126384

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.63
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2, Prkca) plasma membrane (Ntrk2, Prkca) kinase activity (Ntrk2, Prkca)
cell differentiation (Ntrk2) mitochondrion (Prkca) endoplasmic reticulum (Prkca)
Anatomy Link Frequency
spinal cord 2
Bdnf (Mus musculus)
Ntrk2 (Mus musculus)
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 3 100.00 Very High Very High Very High
Spinal cord 1 99.52 Very High Very High Very High
Neuropathic pain 2 97.64 Very High Very High Very High
Brush evoked pain 3 80.60 Quite High
Thermal hyperalgesia 3 79.72 Quite High
spinal dorsal horn 1 72.96 Quite High
intrathecal 1 55.80 Quite High
Sciatic nerve 1 53.40 Quite High
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 5 97.64 Very High Very High Very High
Hyperalgesia 3 79.72 Quite High
Targeted Disruption 1 62.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these findings suggest that the binding of spinally released BDNF to TrkB by nerve ligation may activate PKC within the spinal cord, resulting in the development of a neuropathic pain-like state in mice.
BDNF Binding (binding) of TrkB in spinal cord Spec (like) Positive_regulation (activate) of PKC associated with kinase c, neuropathic pain and spinal cord
1) Confidence 0.49 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15836617 Disease Relevance 0.63 Pain Relevance 0.85

General Comments

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