INT126395

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 7.66
Pain Relevance 6.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1rn) extracellular region (Il1rn) nucleus (Il1rn)
lipid metabolic process (Il1rn) cytoplasm (Il1rn)
Anatomy Link Frequency
brain 6
joints 2
knee joint 2
Il1rn (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 25 100.00 Very High Very High Very High
Paracetamol 32 99.96 Very High Very High Very High
ischemia 78 99.04 Very High Very High Very High
Arthritis 388 98.20 Very High Very High Very High
analgesia 7 98.02 Very High Very High Very High
Morphine 12 97.66 Very High Very High Very High
cytokine 225 96.48 Very High Very High Very High
rheumatoid arthritis 81 95.52 Very High Very High Very High
Analgesic 4 88.96 High High
Inflammation 176 84.80 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 53 99.98 Very High Very High Very High
Stroke 166 99.60 Very High Very High Very High
Sprains And Strains 5 99.58 Very High Very High Very High
Cv Unclassified Under Development 48 99.04 Very High Very High Very High
Arthritis 437 98.20 Very High Very High Very High
Disease 82 98.00 Very High Very High Very High
Brain Injury 28 96.28 Very High Very High Very High
Rheumatoid Arthritis 81 95.52 Very High Very High Very High
Injury 109 95.36 Very High Very High Very High
Adhesions 85 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acetaminophen (APAP) induced increases in intrahepatic expression of interleukin (IL)-1 alpha, IL-1 beta, and IL-1 receptor antagonist (IL-1ra), when administered intraperitoneally.
Positive_regulation (induced) of Gene_expression (expression) of IL-1 receptor antagonist associated with paracetamol and antagonist
1) Confidence 0.41 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19002106 Disease Relevance 0.16 Pain Relevance 0.73
Acetaminophen (APAP) induced increases in intrahepatic expression of interleukin (IL)-1 alpha, IL-1 beta, and IL-1 receptor antagonist (IL-1ra), when administered intraperitoneally.
Positive_regulation (increases) of Gene_expression (expression) of IL-1 receptor antagonist associated with paracetamol and antagonist
2) Confidence 0.41 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19002106 Disease Relevance 0.16 Pain Relevance 0.73
Morphine-induced analgesia was also extended in strains of mice genetically impaired in IL-1 signaling (mice with transgenic over-expression of IL-1 receptor antagonist, deletion of the IL-1 receptor type I, or deletion of the IL-1 receptor accessory protein).
Positive_regulation (over-expression) of Gene_expression (over-expression) of antagonist associated with targeted disruption, antagonist, sprains and strains, analgesia and morphine
3) Confidence 0.21 Published 2005 Journal Pain Section Abstract Doc Link 15836969 Disease Relevance 0.42 Pain Relevance 1.99
Most of the findings here are based on the experiments involving a transgenic mouse strain with brain-directed overexpression of human IL-1ra, in which the balance between IL-1 and IL-1ra is permanently tipped towards inhibiting IL-1 signalling.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-1ra in brain associated with targeted disruption and sprains and strains
4) Confidence 0.15 Published 2009 Journal Brain Behav. Immun. Section Abstract Doc Link 19258032 Disease Relevance 0.61 Pain Relevance 0.08
It was previously reported that mice overexpressing IL-1ra exhibited reduced incidence and severity of CIA, whereas mice deficient in the IL-1ra gene showed accelerated development of arthritis with increased severity [31].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of IL-1ra associated with arthritis
5) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.31 Pain Relevance 0.63
, to be a significant in vivo and in vitro stimulus for murine IL-1ra production [24].
Positive_regulation (stimulus) of Gene_expression (production) of IL-1ra
6) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.65 Pain Relevance 0.38
We found substantial levels of IL-1ra in both nonimmunized wild-type and nonimmunized E/P-selectin mutant mouse joints and serum, but we did not find elevated levels of IL-1ra in E/P-selectin mutant compared with wild-type mice.
Positive_regulation (elevated) of Gene_expression (levels) of IL-1ra in joints
7) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.62 Pain Relevance 0.29
Similarly, local IL-1ra overexpression in the knee joint with viral vectors showed proper efficacy in this model [23].
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-1ra in knee joint
8) Confidence 0.07 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 0.55 Pain Relevance 0.33
will lead to increased levels of IL-1ra, an antagonist of IL-1?.
Positive_regulation (increased) of Gene_expression (levels) of IL-1ra associated with antagonist
9) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.53 Pain Relevance 0.33
will lead to increased levels of IL-1ra, an antagonist of IL-1?.
Positive_regulation (lead) of Gene_expression (levels) of IL-1ra associated with antagonist
10) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.53 Pain Relevance 0.33
Increased levels of endogenous IL-1ra and IL-1RII are likely to be important mechanisms for regulation of IL-1 activity following brain injury.
Positive_regulation (Increased) of Gene_expression (levels) of IL-1ra in brain associated with brain injury
11) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.35 Pain Relevance 0.13
Indeed, adenoviral overexpression of IL-1ra following experimental ischemia reduces ICAM-1 expression and leukocyte infiltration of the brain [57].
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-1ra in brain associated with ischemia
12) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.78 Pain Relevance 0.30

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