INT126396

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.35
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Il1rap) intracellular (Il1rap) protein binding, bridging (Il1rap)
protein complex (Il1rap) signal transducer activity (Il1rap)
Anatomy Link Frequency
dorsal 2
Il1rap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 1 99.96 Very High Very High Very High
Spinal cord 3 98.44 Very High Very High Very High
intrathecal 2 97.56 Very High Very High Very High
Pain 7 92.52 High High
allodynia 4 83.16 Quite High
Inflammation 2 75.84 Quite High
cytokine 3 75.00 Quite High
Sciatic nerve 1 74.44 Quite High
Neuropathic pain 1 73.44 Quite High
Hyperesthesia 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 1 100.00 Very High Very High Very High
Necrosis 1 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 97.64 Very High Very High Very High
Pain 7 92.52 High High
Neuropathic Pain 6 83.16 Quite High
INFLAMMATION 2 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a model of spinal immune activation by intrathecal HIV-1 gp120, we show that the anti-allodynic effects of minocycline are associated with decreased microglial activation, attenuated mRNA expression of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), IL-1beta-converting enzyme, TNF-alpha-converting enzyme, IL-1 receptor antagonist and IL-10 in lumbar dorsal spinal cord, and reduced IL-1beta and TNF-alpha levels in the CSF.
Negative_regulation (attenuated) of Transcription (expression) of IL-1 receptor in dorsal associated with necrosis, cancer, antagonist, acquired immune deficiency syndrome or hiv infection, spinal cord and intrathecal
1) Confidence 0.15 Published 2005 Journal Pain Section Abstract Doc Link 15836971 Disease Relevance 1.35 Pain Relevance 1.32

General Comments

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