INT126402

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.87
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Adarb2) mRNA processing (Adarb2) RNA binding (Adarb2)
nucleus (Adarb2) intracellular (Adarb2) cytoplasm (Adarb2)
Anatomy Link Frequency
brain 2
nerve 1
Adarb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Cancer pain 2 91.96 High High
Hyperalgesia 4 90.88 High High
Pain 1 88.52 High High
adenocard 26 87.56 High High
Neuronal excitability 2 82.52 Quite High
primary afferent fibers 1 79.44 Quite High
calcitonin gene related peptide 5 75.60 Quite High
Central nervous system 10 47.80 Quite Low
Serotonin 28 42.08 Quite Low
Action potential 10 40.00 Quite Low
Disease Link Frequency Relevance Heat
Fibrosarcoma 2 99.16 Very High Very High Very High
Cancer 34 95.48 Very High Very High Very High
Cancer Pain 2 91.96 High High
Hyperalgesia 6 90.88 High High
Pain 1 88.52 High High
Anaplastic Astrocytoma 6 69.36 Quite High
Drug Induced Neurotoxicity 4 56.64 Quite High
Thiamine Deficiency 62 53.84 Quite High
Targeted Disruption 16 42.88 Quite Low
Nociception 1 27.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cross-talk among ADAR1, ADAR2 and ADAR3
Gene_expression (talk) of ADAR3
1) Confidence 0.30 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.07 Pain Relevance 0
ADAR3 is detected only in the brain, but its deaminating activity has not been demonstrated [31,32].
Gene_expression (detected) of ADAR3 in brain
2) Confidence 0.28 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.16 Pain Relevance 0.11
ADAR1 and ADAR2 were shown to be ubiquitously expressed, with enzymatic targets identified mainly in the nervous system while ADAR3 expression is restricted to brain and has yet no known targets [3,23].
Gene_expression (expression) of ADAR3 in brain
3) Confidence 0.27 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0 Pain Relevance 0.09
To this end we introduced the Discoma coral-derived red fluorescent protein (DsRed2) into the NCTC 2472 fibrosarcoma line using the Sleeping Beauty transposon methodology, thus providing a unique opportunity to visualize tumor-nerve-vessel associations in context with behavioral assessment of tumor-associated hyperalgesia.
Gene_expression (introduced) of DsRed2 in nerve associated with fibrosarcoma, hyperalgesia and cancer
4) Confidence 0.03 Published 2005 Journal Pain Section Abstract Doc Link 15836973 Disease Relevance 1.64 Pain Relevance 0.52

General Comments

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