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Context Info
Confidence 0.33
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.94
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ednra) plasma membrane (Ednra) signal transducer activity (Ednra)
Anatomy Link Frequency
eye 2
Ednra (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 29 100.00 Very High Very High Very High
anesthesia 1 82.36 Quite High
Inflammation 5 80.60 Quite High
Serotonin 10 69.96 Quite High
sSRI 3 56.40 Quite High
tolerance 3 49.60 Quite Low
fluoxetine 4 48.36 Quite Low
Pain 3 13.12 Low Low
Calcium channel 8 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 21 99.40 Very High Very High Very High
Pulmonary Hypertension 256 99.20 Very High Very High Very High
INFLAMMATION 8 80.60 Quite High
Pulmonary Disease 3 74.24 Quite High
Hypertrophy 37 73.12 Quite High
Disease 16 59.68 Quite High
Diabetic Retinopathy 1 58.68 Quite High
Eye Disease 1 55.12 Quite High
Infection 3 39.84 Quite Low
Peripheral Arterial Disease 5 29.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result, the expressions of ETA and ETB receptors are reduced with both immunostaining and the mRNA levels in the left eye, in which endothelin-1 eyedrops were applied at 4 x 10(-5) M.
Negative_regulation (reduced) of Gene_expression (expressions) of ETA in eye
1) Confidence 0.33 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15838338 Disease Relevance 0.17 Pain Relevance 0.08
Recent research investigating the role of vasoactive intestinal peptide (VIP) in rats has produced promising results.110 This study showed that ETA antagonists, ETB antagonists, and VIP all prevented the pulmonary vasoconstriction caused by ET1.
Negative_regulation (prevented) of Gene_expression (antagonists) of ETA associated with antagonist and increased venous pressure under development
2) Confidence 0.12 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2697585 Disease Relevance 0.81 Pain Relevance 0.19
Oral sildenafil, a PDE5 inhibitor, prevented (in a study in which sildenafil was given 1 day after MCT) and reversed (in a study in which sildenafil was given 3 weeks after MCT) the development of PAH in MCT-treated rats, associated with a reduction in the ETA-receptor density in SMCs of pulmonary small arteries (diameter < 100??
Negative_regulation (reduction) of Gene_expression (density) of ETA-receptor associated with pulmonary hypertension
3) Confidence 0.10 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.95 Pain Relevance 0.24

General Comments

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