INT126454

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2008
Negated 3
Speculated 0
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 11.82
Pain Relevance 2.63

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extracellular space (Msln) extracellular region (Msln) cell adhesion (Msln)
Golgi apparatus (Msln) plasma membrane (Msln) molecular_function (Msln)
Anatomy Link Frequency
pancreas 3
common bile duct 2
mesothelial cells 1
duct epithelial cells 1
pancreatic ducts 1
Msln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 40 99.54 Very High Very High Very High
Bile 12 96.44 Very High Very High Very High
abdominal pain 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 60 99.84 Very High Very High Very High
Pancreatitis 40 99.54 Very High Very High Very High
Pancreatic Cancer 64 98.92 Very High Very High Very High
Cancer 126 97.66 Very High Very High Very High
Ovarian Cancer 183 96.52 Very High Very High Very High
Disease 72 94.64 High High
Carcinoma 78 86.08 High High
Endometroid Carcinoma 6 71.20 Quite High
Residual Neoplasm 3 53.88 Quite High
Abdominal Pain 3 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mesothelin, a cell surface glycoprotein present on normal mesothelial cells, has been reported to be expressed in pancreatic adenocarcinomas.
Gene_expression (expressed) of Mesothelin in mesothelial cells associated with adenocarcinoma
1) Confidence 0.55 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 16416732 Disease Relevance 0.74 Pain Relevance 0.21
Of 17 specimens of chronic pancreatitis, 16 were negative for mesothelin expression, and 1 case showed weak mesothelin staining of fewer than 5% of normal pancreatic ducts.
Gene_expression (expression) of mesothelin in pancreatic ducts associated with chronic pancreatitis
2) Confidence 0.55 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 16416732 Disease Relevance 1.00 Pain Relevance 0.42
Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis.
Neg (not) Gene_expression (overexpressed) of Mesothelin in pancreas associated with adenocarcinoma and chronic pancreatitis
3) Confidence 0.55 Published 2005 Journal Am. J. Clin. Pathol. Section Title Doc Link 16416732 Disease Relevance 0.96 Pain Relevance 0.31
We conducted this study to fully characterize mesothelin expression in surgically resected, formalin-fixed, paraffin-embedded tissue specimens of 18 pancreatic adenocarcinomas, 9 adenocarcinomas of the ampulla of Vater, 12 adenocarcinomas of the common bile duct, and 17 cases of chronic pancreatitis.
Gene_expression (expression) of mesothelin in common bile duct associated with adenocarcinoma, bile and chronic pancreatitis
4) Confidence 0.55 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 16416732 Disease Relevance 0.88 Pain Relevance 0.24
Our results demonstrated mesothelin expression in the majority of pancreaticobiliary adenocarcinomas and no expression in normal pancreatic tissues and in chronic pancreatitis.
Gene_expression (expression) of mesothelin associated with adenocarcinoma and chronic pancreatitis
5) Confidence 0.48 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 16416732 Disease Relevance 1.14 Pain Relevance 0.42
All 18 cases (100%) of pancreatic adenocarcinomas showed mesothelin expression, as did 8 (89%) of 9 cases of ampullar adenocarcinoma and all 12 cases (100%) of common bile duct adenocarcinoma.
Gene_expression (expression) of mesothelin in common bile duct associated with adenocarcinoma and bile
6) Confidence 0.48 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 16416732 Disease Relevance 1.06 Pain Relevance 0.40
Mesothelin mRNA expression was confirmed with in situ hybridization in all 4 resected primary PCa tumors and with RT-PCR in 18 of 20 PCa cell lines, whereas mesothelin protein expression was confirmed with immunohistochemistry in all 60 resected primary PCa tissues by Argani et al.
Gene_expression (expression) of Mesothelin mRNA associated with cancer and pancreatic cancer
7) Confidence 0.10 Published 2005 Journal Pancreas Section Abstract Doc Link 15841046 Disease Relevance 0.88 Pain Relevance 0.15
Expression of mesothelin mRNA in pure pancreatic juice from patients with pancreatic carcinoma, intraductal papillary mucinous neoplasm of the pancreas, and chronic pancreatitis.
Gene_expression (Expression) of mesothelin mRNA in pancreas associated with cancer, pancreatic cancer and chronic pancreatitis
8) Confidence 0.10 Published 2005 Journal Pancreas Section Title Doc Link 15841046 Disease Relevance 0.86 Pain Relevance 0.16
Mesothelin mRNA expression was discovered using RT-PCR in 11 (52%) of 21 patients with PCa, 5 (45%) of 11 with IPMN, and 3 (14%) of 22 with CP.
Gene_expression (expression) of Mesothelin mRNA
9) Confidence 0.10 Published 2005 Journal Pancreas Section Body Doc Link 15841046 Disease Relevance 0.23 Pain Relevance 0
We evaluated mesothelin mRNA expression in pure pancreatic juice (PPJ) obtained from patients with PCa, chronic pancreatitis (CP), and intraductal papillary mucinous neoplasm (IPMN) of the pancreas.
Gene_expression (expression) of mesothelin mRNA in pancreas associated with cancer, pancreatic cancer and chronic pancreatitis
10) Confidence 0.10 Published 2005 Journal Pancreas Section Abstract Doc Link 15841046 Disease Relevance 1.13 Pain Relevance 0.17
METHODS: We evaluated mesothelin mRNA expression in the PPJ obtained from 21 patients with PCa, 22 with CP, and 11 with IPMN with reverse transcriptase PCR (RT-PCR).
Gene_expression (expression) of mesothelin mRNA
11) Confidence 0.10 Published 2005 Journal Pancreas Section Body Doc Link 15841046 Disease Relevance 0.29 Pain Relevance 0
OBJECTIVES: In the gene expression analysis of pancreatic carcinoma (PCa) using serial analysis of gene expression (SAGE) according to Ryu et al, the tag for the mesothelin mRNA transcript was present in 7 of 8 SAGE libraries derived from PCa but not in the 2 SAGE libraries derived from normal pancreatic duct epithelial cells.
Neg (not) Gene_expression (present) of mesothelin mRNA in duct epithelial cells associated with pancreatic cancer
12) Confidence 0.09 Published 2005 Journal Pancreas Section Abstract Doc Link 15841046 Disease Relevance 0.84 Pain Relevance 0.13
Quantitative detection of mesothelin mRNA in PPJ may have potential diagnostic implications for pancreatic tumors.


Gene_expression (detection) of mesothelin mRNA
13) Confidence 0.08 Published 2005 Journal Pancreas Section Body Doc Link 15841046 Disease Relevance 0.16 Pain Relevance 0
Moreover, the RT-PCR product (226 bp) of mesothelin mRNA in the PPJ samples with PCa was generally stronger than that in the PPJ samples with IPMN.
Gene_expression (product) of mesothelin mRNA
14) Confidence 0.08 Published 2005 Journal Pancreas Section Body Doc Link 15841046 Disease Relevance 0.19 Pain Relevance 0
Many of the markers expressed in other subtypes were either infrequently (<10%) expressed (p53, ER, PAX8, SLPI, K-Cadherin, and CA125), or completely absent (CRABP2, WT-1, and Mesothelin).
Neg (absent) Gene_expression (expressed) of Mesothelin
15) Confidence 0.06 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2592352 Disease Relevance 0.29 Pain Relevance 0
Comparing biomarker expression in the entire cohort for tumors diagnosed at different stages revealed that ten biomarkers (CRABP-II, ER, F-Spondin, K-Cadherin, Ki-67, Matriptase, Mesothelin, p21, p53, and WT1) had significantly different expression levels between stages, suggesting differences between “early” and “late” stage disease (Figure 2, Table S2).
Gene_expression (p21) of Mesothelin associated with cancer and disease
16) Confidence 0.05 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2592352 Disease Relevance 0.64 Pain Relevance 0
In this retrospective study we assessed the protein expression of 21 candidate tissue-based biomarkers (CA125, CRABP-II, EpCam, ER, F-Spondin, HE4, IGF2, K-Cadherin, Ki-67, KISS1, Matriptase, Mesothelin, MIF, MMP7, p21, p53, PAX8, PR, SLPI, TROP2, WT1) in a population-based cohort of 500 ovarian carcinomas that was collected over the period from 1984 to 2000.
Gene_expression (expression) of Mesothelin associated with ovarian cancer
17) Confidence 0.05 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2592352 Disease Relevance 0.54 Pain Relevance 0

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