INT126457

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2011
Negated 11
Speculated 0
Reported most in Body
Documents 34
Total Number 34
Disease Relevance 22.45
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (BCL6) nucleolus (BCL6) nucleus (BCL6)
intracellular (BCL6)
Anatomy Link Frequency
B-cell 5
germinal center B cells 1
germline 1
lymphoid tissue 1
T cells 1
BCL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 20 99.68 Very High Very High Very High
Inflammatory response 3 96.60 Very High Very High Very High
vincristine 5 93.52 High High
positron emission tomography 1 89.76 High High
Pain 22 88.80 High High
Inflammation 50 86.16 High High
medulla 1 85.68 High High
imagery 42 83.56 Quite High
intrathecal 5 83.20 Quite High
methotrexate 21 82.24 Quite High
Disease Link Frequency Relevance Heat
Diffuse Large B-cell Lymphoma 485 99.98 Very High Very High Very High
Follicular Lymphoma 211 99.98 Very High Very High Very High
Lymphatic System Cancer 1975 99.84 Very High Very High Very High
Cancer 570 99.40 Very High Very High Very High
Targeted Disruption 8 98.20 Very High Very High Very High
Mantle-cell Lymphoma 198 98.08 Very High Very High Very High
Hodgkin's Disease 157 97.48 Very High Very High Very High
Disease 379 96.96 Very High Very High Very High
Epstein-barr Virus 196 96.56 Very High Very High Very High
Infection 92 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biopsy of the gastric lesion demonstrated a CD20+, diffuse large B-cell lymphoma that was immunohistochemically positive for BCL-6 and negative for p16.
Neg (negative) Gene_expression (positive) of BCL-6 in B-cell associated with lymphatic system cancer
1) Confidence 0.66 Published 2009 Journal J. Neurosurg. Section Abstract Doc Link 19216652 Disease Relevance 0.58 Pain Relevance 0.39
After stringent correction for multiple hypotheses testing, we identified three genes (G0S2, TXNIP, and BCL6) (Table 1) exhibiting differential expression before and after insulin treatment in both studies.
Gene_expression (expression) of BCL6
2) Confidence 0.51 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.07 Pain Relevance 0
In contrast, the observation that B-cell lymphoma-2 protein overexpression or the lack of caspase 9 abolished apoptosis clearly implicates the intrinsic mitochondrial death pathway in lidocaine-induced apoptosis.


Gene_expression (overexpression) of B-cell lymphoma-2 protein in B-cell
3) Confidence 0.48 Published 2007 Journal Anesthesiology Section Body Doc Link 17585225 Disease Relevance 0 Pain Relevance 0
Apoptosis by lidocaine was strongly reduced by B-cell lymphoma-2 protein overexpression or caspase-9 deficiency, whereas cells lacking the death receptor pathway components caspase 8 and Fas-associated protein with death domain were not protected and displayed similar apoptotic alterations as the parental cells.
Gene_expression (overexpression) of B-cell lymphoma-2 protein in B-cell
4) Confidence 0.48 Published 2007 Journal Anesthesiology Section Body Doc Link 17585225 Disease Relevance 0.07 Pain Relevance 0
The DLBCL expressed CD19, CD20, CD79a, CD5, CD10, CD23, CD38, CD117, bcl-2, and bcl-6, with monotypic expression of immunoglobulin kappa light chain.
Gene_expression (expressed) of bcl-6 associated with diffuse large b-cell lymphoma
5) Confidence 0.36 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 15842045 Disease Relevance 0.76 Pain Relevance 0.11
Neoplastic cells were CD20, PAX-5, CD10, BCL-6, and MUM-1 positive with 70% Ki67 positive nuclei (Figure 2).
Gene_expression (positive) of BCL-6
6) Confidence 0.32 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2582238 Disease Relevance 0.50 Pain Relevance 0.09
The DLBCL expressed CD19, CD20, CD79a, CD5, CD10, CD23, CD38, CD117, bcl-2, and bcl-6, with monotypic expression of immunoglobulin kappa light chain.
Gene_expression (expression) of bcl-6 associated with diffuse large b-cell lymphoma
7) Confidence 0.32 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 15842045 Disease Relevance 0.75 Pain Relevance 0.10
The histology showed B-cells expressing CD20, PAX-5, CD10, BCL-6 and MUM-1 with 70% Ki67 positive nuclei.
Gene_expression (expressing) of BCL-6 in B-cells
8) Confidence 0.29 Published 2008 Journal World J Surg Oncol Section Abstract Doc Link PMC2582238 Disease Relevance 1.71 Pain Relevance 0.04
One hundred forty-nine of 163 DLBCLs could then be classified into GCB group (pattern A), activated GCB group (pattern B), and activated non-GCB group (pattern C) according to the expression of CD10, BCL6, MUM1, and CD138.
Gene_expression (expression) of BCL6
9) Confidence 0.28 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.47 Pain Relevance 0
Uccella et al. used the most common approach with CD10, Bcl-2, BCL6, and MUM1 antibodies in 71 patients and could not find prognostic relevance, although BCL6 expression as single marker was [61].
Gene_expression (expression) of BCL6
10) Confidence 0.28 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.56 Pain Relevance 0.03
Uccella et al. used the most common approach with CD10, Bcl-2, BCL6, and MUM1 antibodies in 71 patients and could not find prognostic relevance, although BCL6 expression as single marker was [61].
Gene_expression (antibodies) of BCL6
11) Confidence 0.24 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.61 Pain Relevance 0.03
3), whereas the PAX5, BCL6, BCL1 cyclin D1, and ALK genes were in germline configuration.
Gene_expression (genes) of BCL6 in germline
12) Confidence 0.24 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.36 Pain Relevance 0
Five of the cases had blastoid morphology, also five were CD5 negative and BCL6 was expressed by another five, showing that the diagnosis of MCL requires knowledge of the full spectrum of the disease [63].
Gene_expression (expressed) of BCL6 associated with mantle-cell lymphoma and disease
13) Confidence 0.22 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.73 Pain Relevance 0
The cells were immunopositive for CD20, BCL-2, and BCL-6 but negative for CD3 and CD43.
Neg (negative) Gene_expression (immunopositive) of BCL-6
14) Confidence 0.21 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC2905343 Disease Relevance 0.64 Pain Relevance 0
Although not statistically significant, it is consistent with recent observations, using gene expression and microarray technology, that Bcl-6 expression and GC differentiation are favorable prognostic factors.21 It is of particular interest that a significant proportion (32%) of the cases with a Bcl-6 gene rearrangement lacked expression of Bcl-6 protein using immunocytochemistry.
Gene_expression (expression) of Bcl-6
15) Confidence 0.19 Published 2009 Journal Rare Tumors Section Body Doc Link PMC2994446 Disease Relevance 0.36 Pain Relevance 0
Expression of Bcl-6 protein has been reported to have an antiapoptotic effect in GC B cells21 and, by analogy with Bcl-2, it may be expected that expression of Bcl-6 protein would be a poor prognostic factor.
Gene_expression (Expression) of Bcl-6 protein
16) Confidence 0.19 Published 2009 Journal Rare Tumors Section Body Doc Link PMC2994446 Disease Relevance 0.62 Pain Relevance 0
This lack of correlation has been reported previously21 and suggests that rearrangement of the Bcl-6 gene does not directly lead to Bcl-6 protein expression in every case.
Gene_expression (expression) of Bcl-6 protein
17) Confidence 0.19 Published 2009 Journal Rare Tumors Section Body Doc Link PMC2994446 Disease Relevance 0.46 Pain Relevance 0
Expression of Bcl-6 protein has been reported to have an antiapoptotic effect in GC B cells21 and, by analogy with Bcl-2, it may be expected that expression of Bcl-6 protein would be a poor prognostic factor.
Gene_expression (expression) of Bcl-6 protein
18) Confidence 0.19 Published 2009 Journal Rare Tumors Section Body Doc Link PMC2994446 Disease Relevance 0.52 Pain Relevance 0
Although not statistically significant, it is consistent with recent observations, using gene expression and microarray technology, that Bcl-6 expression and GC differentiation are favorable prognostic factors.21 It is of particular interest that a significant proportion (32%) of the cases with a Bcl-6 gene rearrangement lacked expression of Bcl-6 protein using immunocytochemistry.
Neg (lacked) Gene_expression (expression) of Bcl-6 protein
19) Confidence 0.19 Published 2009 Journal Rare Tumors Section Body Doc Link PMC2994446 Disease Relevance 0.45 Pain Relevance 0
In this study, we used immunohistochemistry to define Bcl-2 and Bcl-6 expression.
Gene_expression (expression) of Bcl-6
20) Confidence 0.19 Published 2009 Journal Rare Tumors Section Body Doc Link PMC2994446 Disease Relevance 0.48 Pain Relevance 0

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