INT126473

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 18
Disease Relevance 7.86
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (KITLG) signal transduction (KITLG) extracellular space (KITLG)
extracellular region (KITLG) cell adhesion (KITLG) plasma membrane (KITLG)
Anatomy Link Frequency
joint 1
testis 1
stem cell 1
KITLG (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 182 99.84 Very High Very High Very High
Inflammation 120 98.88 Very High Very High Very High
rheumatoid arthritis 336 98.76 Very High Very High Very High
visual analogue scale 14 95.88 Very High Very High Very High
cytokine 12 88.48 High High
depression 14 79.68 Quite High
Chronic pancreatitis 2 73.16 Quite High
Rheumatism 14 70.44 Quite High
melanocortin 1 receptor 1 69.36 Quite High
Pain 28 63.76 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 2 100.00 Very High Very High Very High
Arthritis 182 99.84 Very High Very High Very High
Cancer 9 98.80 Very High Very High Very High
Rheumatoid Arthritis 336 98.76 Very High Very High Very High
INFLAMMATION 50 98.60 Very High Very High Very High
Disease 406 98.44 Very High Very High Very High
Pancreatitis 4 96.32 Very High Very High Very High
Disease Progression 42 95.88 Very High Very High Very High
Mental Disorders 14 93.48 High High
Pancreatic Cancer 7 88.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The K14-SCF transgenic murine model of variant pigmentation is based on epidermal expression of stem cell factor (SCF) on the C57BL/6J background.
Regulation (based) of K14-SCF in stem cell associated with targeted disruption
1) Confidence 0.14 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19682281 Disease Relevance 0.17 Pain Relevance 0.07
Change in EQ-5D and SF-6D over the first year of the BROSG trial was assessed in relation to the EuroQol ‘feelings thermometer’ visual analogue scale (EQ-VAS).
Regulation (Change) of SF-6D associated with visual analogue scale
2) Confidence 0.04 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0.50 Pain Relevance 0.11
There was a significant overall effect of gestational age on the immunostaining levels of ghrelin in the fetal testis (Fig. 7a: p < 0.001), GHSR-1a (Fig. 7b: p < 0.05), SCF (Fig. 7c: p < 0.05) and PCNA (Fig. 7d: p < 0.01).
Regulation (effect) of SCF in testis
3) Confidence 0.04 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
Ghrelin and SCF immunoreactivity required antigen retrieval and used the DAKO ChemMate peroxidase/DAB detection system (DakoCytomation Ltd, Ely, UK).
Regulation (immunoreactivity) of SCF
4) Confidence 0.04 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
Change in DAS28 and its components (tender and swollen joint counts, ESR) was generally more strongly correlated with change in SF-6D score than change in EQ-5D score.
Regulation (change) of SF-6D in joint
5) Confidence 0.03 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0.05 Pain Relevance 0.05
In only one instance were the conclusions based on the ES and SRM conflicting, and where this occurred, the difference between responsiveness of the EQ-5D and SF-6D was marginal.
Regulation (responsiveness) of SF-6D
6) Confidence 0.02 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0.13 Pain Relevance 0.04
We examined the comparative responsiveness of the EQ-5D and SF-6D in cohorts of patients with early inflammatory disease through to severe rheumatoid arthritis (RA).


Spec (examined) Regulation (responsiveness) of SF-6D associated with inflammation, rheumatoid arthritis and disease
7) Confidence 0.02 Published 2009 Journal Qual Life Res Section Abstract Doc Link PMC2761817 Disease Relevance 0.76 Pain Relevance 0.28
Similarly, the greater responsiveness of the SF-6D to improvement supports the majority of previous findings [10, 11].
Regulation (responsiveness) of SF-6D
8) Confidence 0.02 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0.62 Pain Relevance 0.12
The mean change of the EQ-5D exceeded the mean change of the SF-6D in all of the cohorts used in this study.
Regulation (change) of SF-6D
9) Confidence 0.02 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0.23 Pain Relevance 0.03
The comparative responsiveness of the EQ-5D and SF-6D differs according to the direction of change.
Regulation (responsiveness) of SF-6D
10) Confidence 0.02 Published 2009 Journal Qual Life Res Section Abstract Doc Link PMC2761817 Disease Relevance 0.63 Pain Relevance 0.25
The comparative responsiveness of the EQ-5D and SF-6D to change in patients with inflammatory arthritis

Purpose

Regulation (responsiveness) of SF-6D associated with inflammation and arthritis
11) Confidence 0.02 Published 2009 Journal Qual Life Res Section Title Doc Link PMC2761817 Disease Relevance 0.77 Pain Relevance 0.30
Of note, the EQ-5D was more responsive to deterioration in health than the SF-6D, whereas the SF-6D was more responsive to improvement.
Regulation (responsive) of SF-6D
12) Confidence 0.02 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0.75 Pain Relevance 0.13
This study is the first to compare the responsiveness of the EQ-5D and SF-6D to longitudinal changes in UK RA patients with different expected disease trajectories.
Regulation (responsiveness) of SF-6D associated with rheumatoid arthritis and disease
13) Confidence 0.02 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0.73 Pain Relevance 0.15
However, the comparative responsiveness of the EQ-5D and SF-6D differed according to the direction of change.
Regulation (responsiveness) of SF-6D
14) Confidence 0.02 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0 Pain Relevance 0
Comparative evidence regarding the responsiveness of the EQ-5D and SF-6D in arthritis patients is conflicting and insufficient across the range of disease severity.
Regulation (responsiveness) of SF-6D associated with disease and arthritis
15) Confidence 0.02 Published 2009 Journal Qual Life Res Section Abstract Doc Link PMC2761817 Disease Relevance 0.69 Pain Relevance 0.26
The SF-6D was responsive to improvement in cohorts of patients with range of arthritis severity and to deterioration in patients with established stable disease; however, use of the SF-6D in patients with severe progressive disease may be inappropriate.



Regulation (responsive) of SF-6D associated with disease and arthritis
16) Confidence 0.02 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0.38 Pain Relevance 0.10
Similarly, change in HAQ in STIVEA and BSRBR was significantly more strongly correlated with the change in SF-6D score than change in EQ-5D score.
Regulation (change) of SF-6D
17) Confidence 0.02 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0.06 Pain Relevance 0.06
The diagnostic sensitivity of SCF and specificity of M-CSF and tumor markers were the highest.
Regulation (sensitivity) of SCF associated with cancer
18) Confidence 0.02 Published 2005 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 15843207 Disease Relevance 1.37 Pain Relevance 0.39

General Comments

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